Results 11 to 20 of about 111,040 (333)

The snake venom toxin alboaggregin-A activates glycoprotein VI [PDF]

Blood, 2001
The glycoprotein (GP)–Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPIbα-selective snake venom toxin, alboaggregin-A.
Naoki Asazuma, Stuart Marshall, Oscar Berlanga, Daniel Snell, Alastair W. Poole, Michael C. Berndt, Robert K. Andrews, Steve P. Watson   +7 more
openalex   +4 more sources

Platelet glycoprotein VI genetic quantitative and qualitative defects

Platelets, 2019
Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for ...
Martine Jandrot-Perrus, Cedric Hermans, Diego Mezzano   +2 more
doaj   +5 more sources

Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System. [PDF]

Arterioscler Thromb Vasc Biol, 2021
The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on megakaryocytes and platelets and is currently recognized as a receptor for not only collagen but also a variety of plasma and vascular proteins, including fibrin, fibrinogen, laminin, fibronectin, and galectin-3.
Perrella G, Nagy M, Watson SP, Heemskerk JWM.   +3 more
europepmc   +4 more sources

Platelet glycoprotein VI promotes folic acid-induced acute kidney injury through interaction with tubular epithelial cell-derived galectin-3 [PDF]

Cell Communication and Signaling
Background Acute kidney injury (AKI) is defined by a significant reduction in renal function, which subsequently impairs coagulation and activates the inflammatory immune response, ultimately resulting in damage to renal tubular epithelial cells (TECs ...
Ya-Wei Guo, Qi Luo, Meng Lu, Xiang-Bin Zeng, Yu-Min Zhang, Yue-Ling Lin, Xu-Ran Guo, Rong Ma, Zhang-Yin Ming   +8 more
doaj   +2 more sources

Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function [PDF]

Platelets, 2022
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo, Alexander R. Melrose, Jiaqing Pang, Hari Hara Sudhan Lakshmanan, Stéphanie E. Reitsma, Sai Hitesh Vavilapalli, Mark K. Larson, Joseph J. Shatzel, Owen J. T. McCarty, Joseph E. Aslan   +9 more
doaj   +2 more sources

Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI [PDF]

Blood, 2002
The platelet collagen receptor, glycoprotein VI (GPVI), and GPIb-IX-V, which binds von Willebrand factor, initiate platelet aggregation at low or high shear stress, respectively. We recently reported that positively charged, membrane-proximal sequences within cytoplasmic domains of GPIbβ and GPV of GPIb-IX-V bind calmodulin.
Robert K. Andrews, Katsue Suzuki‐Inoue, Yang Shen, David Tulasne, Steve P. Watson, Michael C. Berndt   +5 more
openalex   +4 more sources

Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function [PDF]

Molecules, 2019
Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase.
Luciana S. Oliveira, Maria Inácia Estevão-Costa, Valéria G. Alvarenga, Dan E. Vivas-Ruiz, Armando Yarleque, Augusto Martins Lima, Ana Cavaco, Johannes A. Eble, Eladio F. Sanchez   +8 more
doaj   +2 more sources

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Minka Zivkovic, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Jeroen Eikenboom, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Roger Schutgens, Rolf Urbanus, Carin Uyl, Jan Voorberg, Huan Zhang, Minka Zivkovic   +74 more
doaj   +2 more sources

Glycoprotein VI in securing vascular integrity in inflamed vessels. [PDF]

Res Pract Thromb Haemost, 2018
Glycoprotein VI (GPVI), the main platelet receptor for collagen, has been shown to play a central role in various models of thrombosis, and to be a minor actor of hemostasis at sites of trauma. These observations have made of GPVI a novel target for antithrombotic therapy, as its inhibition would ideally combine efficacy with safety.
Boulaftali Y, Mawhin MA, Jandrot-Perrus M, Ho-Tin-Noé B.   +3 more
europepmc   +4 more sources

Selective Blockade of Glycoprotein VI Clustering on Collagen Helices [PDF]

Journal of Biological Chemistry, 2006
Platelet activation by collagen relies on the interaction of the receptor glycoprotein VI (GPVI) with collagen helices. We have previously generated two recombinant single chain human antibodies (scFvs) to human GPVI. The first, 10B12, binds to the collagen-binding site on the apical surface between the two immunoglobulin-like domains (D1D2) of the ...
Marie O’Connor, Peter A. Smethurst, Lorna W. Davies, Lotta Joutsi‐Korhonen, David J. Onley, Andrew B. Herr, Richard W. Farndale, Willem H. Ouwehand   +7 more
openalex   +5 more sources