Results 41 to 50 of about 111,040 (333)

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 [PDF]

, 2008
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet ...
Barrow, Bijsterbosch, Blake, Braselmann, Burkhardt, Chen, Christou, Cicmil, Clemetson, Daeron, de Vet, Deindl, Dhanjal, Eble, Ezumi, Fuller, Garcia, Gibbins, Grande, Inazu, Isnardi, Jones, Keren, Lerea, Maeda, Monroe, Moroi, Muraille, Newland, Newton, Nieswandt, Nieswandt, Ono, Patil, Poole, Quek, Ravetch, Reedquist, Roose, Senis, Shapiro, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Takata, Tomlinson, van Oers, Verbrugge, Vivier, Washington, Washington, Watson   +51 more
core   +3 more sources

Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis. [PDF]

PLoS One, 2017
Stack JR, Madigan A, Helbert L, Dunne E, Gardiner EE, Andrews RK, Finan R, Smyth E, Kenny D, McCarthy GM.   +9 more
europepmc   +3 more sources

Mice lacking the inhibitory collagen receptor LAIR-1 exhibit a mild thrombocytosis and hyperactive platelets [PDF]

, 2017
Objective— Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a collagen receptor that belongs to the inhibitory immunoreceptor tyrosine-based inhibition motif–containing receptor family.
Bem, Danai, Byrne, Maxwell, Lordkipanidze, Marie, Mazharian, Alexandra, Meyaard, Linde, Patel, Pushpa, RASLAN, Zaher, Senis, Yotis, Smith, Christopher, Thomas, Steven, Watson, Steve   +10 more
core   +1 more source

Glycoprotein VI interplay with fibrin(ogen) in thrombosis

Journal of Thrombosis and Haemostasis, 2023
Platelets play a central role in the arrest of bleeding. The ability of platelets to engage with extracellular matrix proteins of the subendothelium has long been recognized as a pivotal platelet attribute, underpinning adequate hemostasis. The propensity of platelets to rapidly bind and functionally respond to collagen was one of the earliest ...
Pierre H, Mangin, Elizabeth E, Gardiner, Robert A S, Ariëns, Martine, Jandrot-Perrus   +3 more
openaire   +2 more sources

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

Biomedicines, 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming   +9 more
doaj   +1 more source

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
core   +1 more source

The relationship between platelet glycoprotein VI T13254C polymorphism and acute myocardial infarction (MI) [PDF]

پیاورد سلامت, 2011
Background and Aim: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Epidemiological studies indicate that MI results from complex interactions between long-term environmental influences, concomitant disorders, and ...
A Fatemi, A Kazemi, MM Peighambari, N Givtaj, H Bakhshandeh   +4 more
doaj   +1 more source

Increased platelet reactivity as measured by plasma glycoprotein VI in gout

Platelets, 2018
Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, is proteolytically cleaved upon platelet activation, and detectable in plasma as soluble GPVI ...
Richard Conway, Claire-Louise Murphy, Anne Madigan, Patricia Kavanagh, Liz Geraghty, Niamh Redmond, Laura Helbert, John J. Carey, Eimear Dunne, Dermot Kenny, Geraldine M. McCarthy   +10 more
doaj   +1 more source

Polymerized fibrin activates glycoprotein VI [PDF]

Blood, 2015
In this issue of Blood , [Mammadova-Bach et al][1] show that polymerized fibrin binds to the platelet receptor glycoprotein VI (GPVI), amplifying thrombin generation and enhancing thrombus growth.[1][2] ![Figure][3] GPVI amplifies thrombin generation and platelet aggregation. PS,
openaire   +3 more sources

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets

Frontiers in Medicine, 2020
Tussilagone is a sesquiterpenoid extracted from Tussilago farfara and is used as an oriental medicine for asthma and bronchitis. Although previous studies have shown that tussilagone has an inhibitory effect on platelet aggregation, no studies have been ...
Jing Zhou, Ru-Ping Yang, Wei Song, Hui-Min Xu, Yong-Hui Wang   +4 more
doaj   +1 more source