Mechanical model for a collagen fibril pair in extracellular matrix [PDF]
arXiv, 2009 In this paper, we model the mechanics of a collagen pair in the connective tissue extracellular matrix that exists in abundance throughout animals, including the human body. This connective tissue comprises repeated units of two main structures, namely collagens as well as axial, parallel and regular anionic glycosaminoglycan between collagens.
arxiv
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
, 2008 Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
core +1 more source
Advanced Science, EarlyView.Fusion protein PDGFB‐LG4 exhibits superior osteoinductive and angiogenic activity compared to PDGFB. The PCLHS‐PDGFB‐LG4 scaffold, featuring perfusable and permeable vascular‐like networks, promotes angiogenesis and osteogenesis through the sustained release of PDGFB‐LG4, thereby accelerating the bone defect repair process.
Jiahua Duan +6 more
wiley +1 more source
Exploration of ImmunologyAim: Severe dengue is correlated with a decrease in the circulating complement regulator, factor H (FH) and prior work has shown that dengue virus (DENV) infection induces FH mRNA but not FH protein release.
Joshua G. Dubowsky +5 more
doaj +1 more source
Age-Related Molecular Polymorphism of the Heterodimeric Proteoglycan Bisdermican
The Scientific World Journal, 2004 Bisdermican (PG760) is a large, heterodimeric, dermatan sulfate proteoglycan found in selected basement membranes, smooth muscle cell layers, and different extracellular matrices.
Martin Götte +2 more
doaj +1 more source
Comparative Effectiveness of Structural versus Regulatory Protein Gene Transfer on Articular Chondrocyte Matrix Gene Expression [PDF]
, 2019 OBJECTIVE: The production of extracellular matrix is a necessary component of articular cartilage repair. Gene transfer is a promising method to improve matrix biosynthesis by articular chondrocytes.
Chan, Albert +5 more
core +1 more source
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source
Could Biglycan be a biomarker of coronary artery disease? A pilot human study
Research in Cardiovascular Medicine, 2018 Background: Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk.
Atefeh Rezapour +9 more
doaj +1 more source
Quantification of heparin in complex matrices (including urine) using a mix-and-read fluorescence assay [PDF]
arXiv, 2016 Heparin is an important anticoagulant drug, about one billion doses are produced annually. It is a polydisperse sulfated polysaccharide, and the inherent heterogeneity makes the analysis of heparin difficult. The global crisis resulting from adulterated heparin in 2008 has drawn renewed attention to the challenges that are associated with the quality ...
arxiv
Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan [PDF]
, 2000 It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated.
Bellina, Isabella +11 more
core