Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™. [PDF]
Biomolecules, 2013 Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Dykstra, Andrew B +2 more
core +4 more sources
Chemical Modification of Hyaluronan and Their Biomedical Applications
Frontiers in Chemistry, 2022 Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts.
Vera Hintze +2 more
doaj +1 more source
Effect of Glycosaminoglycan Replacement on Markers of Interstitial Cystitis In Vitro
Frontiers in Pharmacology, 2020 Aims: To examine the effect of three commercial intravesical formulations of glycosaminoglycan on in vitro inflammatory models of IC/BPS to better understand there effect on specific markers of disease.Methods: Human urothelial cells (HTB-4) were ...
Peadar Rooney +8 more
doaj +1 more source
Mathematical Modeling of Microscale Biology: Ion Pairing, Dielectric Decrement, and Born Energy in Glycosaminoglycan Brushes [PDF]
, 2022 Biological macromolecules including nucleic acids, proteins, and glycosaminoglycans are typically anionic and can span domains of up to hundreds of nanometers and even micron length scales. The structures exist in crowded environments that are dominated by weak multivalent electrostatic interactions that can be modeled using mean field continuum ...
arxiv +1 more source
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Frontiers in Cell and Developmental Biology, 2020 Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw. They represent not only the primary tumor site, but also potential metastatic lesions, and could thus be an attractive supplement for cancer diagnostics.
Theresa D. Ahrens +12 more
doaj +1 more source
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface, extracellular milieu, and intracellular granules, are fundamental to life.
Krishna Rajarathnam +3 more
doaj +1 more source
Genistein Enhances or Reduces Glycosaminoglycan Quantity in a Cell Type-Specific Manner
Cellular Physiology and Biochemistry, 2018 Background/Aims: Genistein is a natural isoflavone enriched in soybeans. It has beneficial effects for patients with mucopolysaccharidose type III through inhibiting glycosaminoglycan biosynthesis.
Ying Lan +8 more
doaj +1 more source
A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring [PDF]
European Cells & Materials, 2018 Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain ...
X Liu +7 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Self-propagating form of the prion protein (PrPSc) causes many neurodegenerative diseases, such as Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker syndrome (GSS).
So Young Kim +5 more
doaj +1 more source