Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™ [PDF]
Biomolecules, 2013 Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Julie A. Leary +2 more
doaj +4 more sources
Molecules, 2022 Glycosaminoglycans (GAGs) are a class of periodic anionic linear polysaccharides involved in a number of biologically relevant processes in the extracellular matrix via interactions with various types of molecules including proteins, peptides and small ...
Martyna Maszota-Zieleniak +2 more
doaj +1 more source
Chemical Modification of Hyaluronan and Their Biomedical Applications
Frontiers in Chemistry, 2022 Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts.
Vera Hintze +2 more
doaj +1 more source
Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
Bioengineering, 2020 The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary ...
Colton J. Ross +4 more
doaj +1 more source
Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]
, 2016 Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K. +4 more
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A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring [PDF]
European Cells & Materials, 2018 Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain ...
X Liu +7 more
doaj +1 more source
IR action spectroscopy of glycosaminoglycan oligosaccharides [PDF]
, 2020 Glycosaminoglycans (GAGs) are a physio- and pharmacologically highly relevant class of complex saccharides, possessing a linear sequence and strongly acidic character.
Freyse, Joanna +9 more
core +2 more sources
Effect of Glycosaminoglycan Replacement on Markers of Interstitial Cystitis In Vitro
Frontiers in Pharmacology, 2020 Aims: To examine the effect of three commercial intravesical formulations of glycosaminoglycan on in vitro inflammatory models of IC/BPS to better understand there effect on specific markers of disease.Methods: Human urothelial cells (HTB-4) were ...
Peadar Rooney +8 more
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Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1
Marine Drugs, 2021 Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years.
Courtney J. Mycroft-West +10 more
doaj +1 more source
Genistein Enhances or Reduces Glycosaminoglycan Quantity in a Cell Type-Specific Manner
Cellular Physiology and Biochemistry, 2018 Background/Aims: Genistein is a natural isoflavone enriched in soybeans. It has beneficial effects for patients with mucopolysaccharidose type III through inhibiting glycosaminoglycan biosynthesis.
Ying Lan +8 more
doaj +1 more source