Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome
Journal of Histochemistry and Cytochemistry, 2020 The six mammalian glycosaminoglycans (GAGs), chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan sulfate, are linear polysaccharides. Except for hyaluronan, they are sulfated to various extent, and covalently attached
Sylvain D. Vallet +2 more
semanticscholar +1 more source
Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly
Cells, 2020 Proper processing of collagens COL1 and COL6 is required for normal function of adipose tissue and skeletal muscle. Proteoglycan decorin (DCN) regulates collagen fiber formation.
Alexes C. Daquinag +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Self-propagating form of the prion protein (PrPSc) causes many neurodegenerative diseases, such as Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker syndrome (GSS).
So Young Kim +5 more
doaj +1 more source
Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation
Frontiers in Immunology, 2020 Leukocyte migration into tissues depends on the activity of chemokines that form concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with their specific G protein-coupled receptors (GPCRs) on leukocytes induces ...
Helena Crijns +2 more
semanticscholar +1 more source
Anti-diabetic activity of field cricket glycosaminoglycan by ameliorating oxidative stress
BMC Complementary Medicine and Therapies, 2020 Background Field cricket ( Gryllus bimaculatus ) is newly emerged as an edible insect in several countries. Anti-inflammatory effect of glycosaminoglycan derived from this cricket on chronic disease animal model such as diabetic mouse has not been fully ...
M. Ahn +6 more
semanticscholar +1 more source
Genistein Enhances or Reduces Glycosaminoglycan Quantity in a Cell Type-Specific Manner
Cellular Physiology and Biochemistry, 2018 Background/Aims: Genistein is a natural isoflavone enriched in soybeans. It has beneficial effects for patients with mucopolysaccharidose type III through inhibiting glycosaminoglycan biosynthesis.
Ying Lan +8 more
doaj +1 more source
Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro [PDF]
, 2002 The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological ...
B. L HAZLEMAN +16 more
core +1 more source
Molecules, 2020 Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan sulfate, a linear polysaccharide from the ...
Thibault Annaval +5 more
doaj +1 more source
Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
core +2 more sources
Glycosaminoglycans and Contrast Agents: The Role of Hyaluronic Acid as MRI Contrast Enhancer
Biomolecules, 2020 A comprehensive understanding of the behaviour of Glycosaminoglycans (GAGs) combined with imaging or therapeutic agents can be a key factor for the rational design of drug delivery and diagnostic systems.
Alfonso Maria Ponsiglione +2 more
doaj +1 more source