Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar [PDF]
Beilstein Journal of Organic Chemistry, 2015 The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne ...
Camilla Matassini +5 more
doaj +4 more sources
1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor [PDF]
, 2017 The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Aerts, Johannes M.F.G. +12 more
core +26 more sources
Molecular Docking Analysis of Embelia ribes for Selected Constituents as Spodoptera frugiperda (Fall Armyworm) Beta Glycosidase and Caspase-1 Inhibitors [PDF]
Nature Environment and Pollution Technology, 2023 Insect pest control is one of the major issues facing the agriculture sector because of the need for new agrochemicals and biocontrol agents that are environmentally friendly, economically affordable, and safe for human health.
Srinivasan Kumaraswamy, Vasantha-Srinivasan Prabhakaran and Radhakrishnan Narayanaswamy
doaj +1 more source
Frontiers in Chemistry, 2021 α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and promote glucose conversion, which have been used for the treatment of type 2 diabetes.
Shan-Kui Liu +13 more
doaj +1 more source
Frontiers in Microbiology, 2022 α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity ...
Xiaojing Wang +16 more
doaj +1 more source
Molecules, 2021 Lytic transglycosylases such as Slt35 from E. coli are enzymes involved in bacterial cell wall remodelling and recycling, which represent potential targets for novel antibacterial agents. Here, we investigated a series of known glycosidase inhibitors for
Aysha B. Mezoughi +8 more
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Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance
Molecules, 2022 Recently, the strategy of multivalency has been widely employed to design glycosidase inhibitors, as glycomimetic clusters often induce marked enzyme inhibition relative to monovalent analogs.
Yali Wang +3 more
doaj +1 more source
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [PDF]
, 2018 The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out.
Carmona Asenjo, Ana Teresa +8 more
core +1 more source
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]
, 2015 MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng +6 more
core +2 more sources
Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]
, 2013 Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter +7 more
core +5 more sources