Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryWe developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase ...
Zorana Ferjancic +15 more
doaj +2 more sources
Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors [PDF]
Angewandte Chemie - International Edition, 2023 Po-Sen Tseng +2 more
exaly +2 more sources
Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]
PlantsAmorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash +3 more
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Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts [PDF]
, 2016 A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized. The key step involved a totally stereocontrolled C-Michael addition of a serine-equivalent C-nucleophile to tri-O ...
Avenoza, A. +9 more
core +1 more source
Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil
International Journal of Food Properties, 2019 Isoeugenol (2-methoxy-4-(prop-1-en-1-yl)phenol), a component of from clove (Eugenia caryophylata) oil, is a starting material for both the biotechnological and synthetic production of vanillin and vanillic acid.
Fevzi Topal
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Novel pyrrolizidine alkaloid [PDF]
, 1991 The present invention involves a purified bioactive compound of the formula: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H or an acyl having less than about five carbon atoms.
Elbein, Alan D., Tropea, Joseph E.
core +1 more source
Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
Natural Products and Bioprospecting, 2022 Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala ...
Ghodsi Mohammadi Ziarani +2 more
doaj +1 more source
p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death [PDF]
, 2016 p53 is a central factor in tumor suppression as exemplified by its frequent loss in human cancer. p53 exerts its tumor suppressive effects in multiple ways, but the ability to invoke the eradication of damaged cells by programmed cell death is considered
Baudot, Alice D. +5 more
core +2 more sources
Inhibition of an extracellular polygalacturonase from Geotrichum candidum by a proteinaceous inhibitor isolated from lemon fruits [PDF]
, 2017 An extracellular polygalacturonase [EC 3.2.1.15], named PG-543, was purified from the culture of Geotrichum candidum IEV 543, a phytopathogenic fungi isolated from infected lemon.
Isla, Maria Ines +5 more
core +1 more source
Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines [PDF]
, 2017 Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing ...
Adriaan J. Minnaard +39 more
core +6 more sources