Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins).
PLoS ONE, 2014 Glycosidases are associated with various human diseases. The development of efficient and specific inhibitors may provide powerful tools to modulate their activity.
Agustín Correa +8 more
doaj +1 more source
?-Trimethylsilylmethylamine Radical Cation in the Synthesis of Cyclic Amines and Beyond
CHIMIA, 2013 The evolution of chemistry associated with the photoinduced electron transfer (PET)-generated ?-trimethylsilylmethylamine radical cation cyclization to a tethered olefin to synthesize cyclic amine structural frame works is presented in ...
Ganesh Pandey +2 more
doaj +1 more source
Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection [PDF]
, 2019 Pollens are well-known triggers of respiratory allergies and asthma. The pollen burden in today's ambient air is constantly increasing due to rising climate change and air pollution.
Gevaert, Kris +6 more
core +3 more sources
CHIMIA, 2012 Glycals have been transformed into a variety of functionalized substrates which have been found to be useful in synthesizing some aminosugars, N-glycopeptides, nitrosugars and some iminosugars which are potential glycosidase inhibitors.
Rima Lahiri +2 more
doaj +1 more source
Diels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitors [PDF]
, 2012 This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification.
Alves, M. José +3 more
core +1 more source
Syntheses and Biological Activities of 1,4-Iminoalditol Derivatives as ?-L-Fucosidase Inhibitors
CHIMIA, 2011 A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of ?-L-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
Elena Moreno-Clavijo +4 more
doaj +1 more source
Synthesis of enantiomeric polyhydroxyalkylpyrrolidines from 1,3-dipolar cycloadducts. Evaluation as inhibitors of a β-galactofuranosidase [PDF]
, 2016 Enantiomeric 2,3,4-tris(hydroxyalkyl)-5-phenylpyrrolidines have been synthesized from the major cycloadducts obtained by the 1,3-dipolar cycloaddition of sugar enones with azomethine ylides derived from natural amino acids.
Oliveira Udry, Guillermo Alejandro +3 more
core +2 more sources
Molecules, 2020 Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning
Patrick Weber +18 more
doaj +1 more source
Results in Chemistry, 2023 We report here the synthesis and biological evaluation of dideoxynojirimycin and its analogs and their functional effect on glucosidase enzyme inhibition against α-glucosidase(yeast), α-galactosidase and β-galactosidase (kluyveromyces lactis).
Jattuboyina Siva Krishna +8 more
doaj +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources