Results 81 to 90 of about 16,712 (156)

Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives

Beilstein Journal of Organic Chemistry, 2005
BackgroundMany polyhydroxylated piperidines are inhibitors of the oligosaccharide processing enzymes, glycosidases and glycosyltransferases. Aza-C-linked disaccharide mimetics are compounds in which saturated polyhydroxylated nitrogen and oxygen ...
Andrew Kennedy, Adam Nelson, Alexis Perry   +2 more
doaj   +1 more source

Whole genome sequencing for mutation discovery in a single case of lysosomal storage disease (MPS type 1) in the dog. [PDF]

, 2020
Mucopolysaccharidosis (MPS) is a metabolic storage disorder caused by the deficiency of any lysosomal enzyme required for the breakdown of glycosaminoglycans.
Aguilar, Miriam, Ancona, Devin, Bannasch, Danika, Brown, C. Titus, Cowan, Tina, Knipe, Marguerite, Mansour, Tamer, Moore, Bret, Seada, Haitham, Sebbag, Lionel, Sebbag, Lionel, Thomasy, Sara, Vernau, Karen, Woolard, Kevin   +13 more
core   +3 more sources

Synthesis and glycosidase inhibitory activity of new hexa-substituted C8-glycomimetics

Beilstein Journal of Organic Chemistry, 2005
BackgroundGlycosidases are involved in several metabolic pathways and the development of inhibitors is an important challenge towards the treatment of diseases, such as diabetes, cancer and viral infections including AIDS.
Olivia Andriuzzi, Christine Gravier-Pelletier, Gildas Bertho, Thierry Prangé, Yves Le Merrer   +4 more
doaj   +1 more source

A formal total synthesis of deoxynojirimycin from D-glucitol

Journal of the Brazilian Chemical Society, 2003
This report deals with the formal synthesis of deoxynojirimycin using D-glucitol as an inexpensive starting material. Through a sequence of several selective protection/deprotection and nucleophilic substitution reactions, many isopropylidene derivatives
Braga Raquel M., Kato Lucilia
doaj  

Facing Glycoscience

CHIMIA, 2001
This essay describes an approach facing some of the challenges of glycoscience, concentrating on the relation between structure and reactivity. This has resulted in new methods, precursors of carbohydrate-derived reactive intermediates, analysis
Andrea Vaselia
doaj  

Recent Applications of the Simple Hydrocarbon Cyclooctatetrene as a Starting Material for Complex Molecule Synthesis [PDF]

, 2012
Cyclooctatetraene [COT], a simple non-aromatic cyclic polyene, is capable of undergoing a variety of oxidation and cycloaddition reactions to afford polycyclic structures.
Donaldson, William, Glaeske, Kevin W
core   +2 more sources

Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors

ARKIVOC, 2002
Dilip D. Dhavale, Vijaya N. Desai, Nabendu N. Saha, Jayant N. Tilekar   +3 more
doaj   +1 more source

Effect of α-glycosidase inhibitors from endophytic fungus Alternaria destruens on survival and development of insect pest Spodoptera litura Fab. and fungal phytopathogens. [PDF]

Sci Rep, 2019
Kaur J, Sharma A, Sharma M, Kumari Manhas R, Kaur S, Kaur A.   +5 more
europepmc   +1 more source

The chemistry of antipredator defense by secondary compounds in neotropical lepidoptera: facts, perspectives and caveats

Journal of the Brazilian Chemical Society, 2000
Chemical defense against predation in butterflies and moths has been studied since nineteenth century. A classical example is that of the larvae of the monarch butterfly Danaus plexippus, which feed on leaves of Asclepias curassavica (Asclepiadaceae ...
Trigo José R.
doaj  

Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors. [PDF]

European J Org Chem, 2019
Artola M, Wouters S, Schröder SP, de Boer C, Chen Y, Petracca R, van den Nieuwendijk AMCH, Aerts JMFG, van der Marel GA, Codée JDC, Overkleeft HS.   +10 more
europepmc   +1 more source