The FASEB Journal, Volume 40, Issue 6, 31 March 2026.ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek +7 more
wiley +1 more source
Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities
Journal of Lipid Research, 2014 Lysosomes play a vital role in the maintenance of cellular homeostasis through the recycling of cell constituents, a key metabolic function which is highly dependent on the correct function of the lysosomal hydrolases and membrane proteins, as well as ...
Linda Ingemann, Thomas Kirkegaard
doaj +1 more source
Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]
, 2013 Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis +4 more
core +2 more sources
Glycosphingolipids Are Essential for Intestinal Endocytic Function*
Journal of Biological Chemistry, 2012 Background: The intestine contains high concentrations of glycosphingolipids, but their function remained unclear. Results: In newborn mice lacking glycosphingolipids, intestinal epithelia were indistinguishable from control littermates.
R. Jennemann +10 more
semanticscholar +1 more source
Laurdan: Clarifying Photophysics and Advancing the Characterization of Extracellular Vesicles
ChemPhysChem, Volume 27, Issue 5, 13 March 2026.Biophysical properties of extracellular vesicles (EVs) reflect their composition and membrane organization. We introduce a novel approach using time‐resolved emission spectra (TRES) phasor analysis of the polarity‐sensitive probe Laurdan to characterize membranes with complex compositions.
Petra Riegerová +8 more
wiley +1 more source
Journal of Lipid Research, 2008 The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet.
Elias N. Glaros +5 more
doaj +1 more source
The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]
, 2006 Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, Thomas +7 more
core +3 more sources
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, Volume 13, Issue 14, 9 March 2026.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Functional role of gangliosides in cell membranes: from physiology to pathogenesis
Acta Biomedica ScientificaGangliosides are complex glycosphingolipids that constitute essential components of cell membranes and actively participate in the regulation of numerous biological processes.
E. M. Ustinov, I. A. Andrievskaya
doaj +1 more source
Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease [PDF]
, 2018 K
Batta, Gyula +7 more
core +2 more sources