Results 31 to 40 of about 25,840 (267)

β-Glycosphingolipids as Mediators of Both Inflammation and Immune Tolerance: A Manifestation of Randomness in Biological Systems

Frontiers in Immunology, 2019
Plasticity in biological systems is attributed to the combination of multiple parameters which determine function. These include genotypic, phenotypic, and environmental factors.
Y. Ilan
semanticscholar   +1 more source

New era of research on cancer‐associated glycosphingolipids

Cancer Science, 2019
Cancer‐associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis of their implications in the malignant properties of cancer cells revealed that cancer ...
Kazuro Furukawa, Yuhsuke Ohmi, Y. Ohkawa, R. H. Bhuiyan, Pu Zhang, O. Tajima, N. Hashimoto, K. Hamamura, Keiko Furukawa   +8 more
semanticscholar   +1 more source

Glycosphingolipids and Infection. Potential New Therapeutic Avenues

Front. Cell Dev. Biol., 2019
Glycosphingolipids (GSLs), the main topic of this review, are a subclass of sphingolipids. With their glycans exposed to the extracellular space, glycosphingolipids are ubiquitous components of the plasma membrane of cells.
J. Aerts, M. Artola, M. V. Eijk, M. Ferraz, R. Boot   +4 more
semanticscholar   +1 more source

A perilous path: the inborn errors of sphingolipid metabolism

Journal of Lipid Research, 2019
The sphingolipid (SL) metabolic pathway generates structurally diverse lipids that have roles as membrane constituents and as bioactive signaling molecules.
Teresa M. Dunn, Cynthia J. Tifft, Richard L. Proia   +2 more
doaj   +1 more source

Glycosphingolipids in Filamentous Fungi: Biological Roles and Potential Applications in Cosmetics and Health Foods

Frontiers in Microbiology, 2021
Filamentous fungi are a group of economically important fungi used in the production of fermented foods, industrial enzymes, and secondary metabolites. Glycosphingolipids (GSLs) as constituents of lipid rafts are involved in growth, differentiation, and ...
Chunmiao Jiang, Jinxin Ge, Bin He, Bin Zeng, Bin Zeng   +4 more
doaj   +1 more source

Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitorings⃞

Journal of Lipid Research, 2008
Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) has been applied primarily to the analysis of glycosphingolipids separated from other complex mixtures by TLC, but it is difficult to obtain quantitative profiling of each ...
Kazutaka Ikeda, Takao Shimizu, Ryo Taguchi   +2 more
doaj   +1 more source

Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice

Journal of Lipid Research, 2008
Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE−/−) mice indicate that exacerbated tissue GSL accumulation resulting from α-galactosidase deficiency promotes atherosclerosis, whereas ...
Elias N. Glaros, Woojin S. Kim, Kerry-Anne Rye, James A. Shayman, Brett Garner   +4 more
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Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs

Journal of Biological Chemistry, 2018
Lipid transport is an essential process with manifest importance to human health and disease. Phospholipid flippases (P4-ATPases) transport lipids across the membrane bilayer and are involved in signal transduction, cell division, and vesicular transport.
B. Roland, Tomoki Naito, Jordan T Best, Cayetana Arnaiz-Yépez, H. Takatsu, Roger J. Yu, Hye-Won Shin, T. Graham   +7 more
semanticscholar   +1 more source

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Cells, 2021
As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells.
Sibylle Schneider-Schaulies, Fabian Schumacher, Dominik Wigger, Marie Schöl, Trushnal Waghmare, Jan Schlegel, Jürgen Seibel, Burkhard Kleuser   +7 more
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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

eLife, 2018
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery.
M. Garcia-Castillo, D. Chinnapen, Y. T. te Welscher, Rodrigo J. Gonzalez, S. Softic, Michele Pacheco, R. Mrsny, C. Kahn, U. V. von Andrian, J. Lau, B. Pentelute, W. Lencer   +11 more
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