Results 41 to 50 of about 36,633 (265)

Glycosphingolipids of human embryonic stem cells

Glycoconjugate Journal, 2016
The application of human stem cell technology offers theoretically a great potential to treat various human diseases. However, to achieve this goal a large number of scientific issues remain to be solved.
M. Breimer, K. Säljö, Angela Barone, S. Teneberg   +3 more
semanticscholar   +1 more source

A perilous path: the inborn errors of sphingolipid metabolism

Journal of Lipid Research, 2019
The sphingolipid (SL) metabolic pathway generates structurally diverse lipids that have roles as membrane constituents and as bioactive signaling molecules.
Teresa M. Dunn, Cynthia J. Tifft, Richard L. Proia   +2 more
doaj   +1 more source

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

, 2020
A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS).
Barsch, A., Brunner, A., Mann, M., Meier, F., Meitei, N., Meyer, S., Schweiger-Hufnagel, U., Sulek, K., Vasilopoulou, C.   +8 more
core   +1 more source

Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitorings⃞

Journal of Lipid Research, 2008
Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) has been applied primarily to the analysis of glycosphingolipids separated from other complex mixtures by TLC, but it is difficult to obtain quantitative profiling of each ...
Kazutaka Ikeda, Takao Shimizu, Ryo Taguchi   +2 more
doaj   +1 more source

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Cells, 2021
As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells.
Sibylle Schneider-Schaulies, Fabian Schumacher, Dominik Wigger, Marie Schöl, Trushnal Waghmare, Jan Schlegel, Jürgen Seibel, Burkhard Kleuser   +7 more
doaj   +1 more source

Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice

Journal of Lipid Research, 2008
Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE−/−) mice indicate that exacerbated tissue GSL accumulation resulting from α-galactosidase deficiency promotes atherosclerosis, whereas ...
Elias N. Glaros, Woojin S. Kim, Kerry-Anne Rye, James A. Shayman, Brett Garner   +4 more
doaj   +1 more source

Bright spots in the darkness of cancer: A review of starfishes-derived compounds and their anti-tumor action [PDF]

, 2019
The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable.
Arizza V., Lazzara V., Luparello C., Mauro M., Vazzana M.   +4 more
core   +1 more source

Structural Characterization of Neutral Glycosphingolipids from 3T3-L1 Adipocytes

Lipids, 2015
In recent years, obesity has been considered a pathological stage of early lifestyle-related diseases, and adipose tissue and adipocyte research has been active.
H. Kojima, Yusuke Suzuki, Masahiro Ito, Kazuya Kabayama   +3 more
semanticscholar   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Furukawa, K., Furukawa, K., Jacobs, B.C., Plomp, J.J., Todorov, B., Verschuuren, J.J., Willison, H.J., Zitman, F.M.P.   +7 more
core   +1 more source

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources