Results 1 to 10 of about 191,408 (290)

Unlocking the Sugar Code: Implications and Consequences of Glycosylation in Alzheimer’s Disease and Other Tauopathies [PDF]

Biomedicines
Alzheimer’s disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline, amyloid-β (Aβ) plaques, and neurofibrillary tangles composed of hyperphosphorylated tau protein. Other tauopathies, including frontotemporal
Andrei-Cristian Bondar, Marius P. Iordache, Mirela Coroescu, Anca Buliman, Elena Rusu, Magdalena Budișteanu, Cristiana Tanase   +6 more
doaj   +4 more sources

Dynamic glycosylation remodeling in neurological disorders [PDF]

Frontiers in Molecular Neuroscience
Glycosylation, a crucial post-translational modification, involves the covalent attachment of monosaccharides or oligosaccharides to proteins. This process significantly influences protein stability and function.
Dan Xing, Yingxun Gong, Weiyi Xia, Huifang Tu, Huifang Tu, Limei Yuan, Yiqing Yin, Kaiyuan Wang, Kaiyuan Wang   +8 more
doaj   +2 more sources

Computational analysis reveals non-consensus N-glycosylation sequons in antibody Fab region [PDF]

mAbs
Protein glycosylation at asparagine typically occurs at a consensus motif. However, recent studies have reported instances of N-glycosylation at non-consensus sites, though the mechanisms and implications of these atypical modifications remain unclear ...
Baiyu Qiu, Edwin Chen, Tawnya Flick, Simon Letarte   +3 more
doaj   +2 more sources

O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis

Frontiers in Immunology, 2023
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Junghwa Seo, Yeolhoe Kim, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Hyeryeon Jung, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Injae Shin, Injae Shin, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +16 more
doaj   +1 more source

Role of Sialyl-O-Acetyltransferase CASD1 on GD2 Ganglioside O-Acetylation in Breast Cancer Cells

Cells, 2021
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer.
Sumeyye Cavdarli, Larissa Schröter, Malena Albers, Anna-Maria Baumann, Dorothée Vicogne, Jean-Marc Le Doussal, Martina Mühlenhoff, Philippe Delannoy, Sophie Groux-Degroote   +8 more
doaj   +1 more source

O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity

Frontiers in Immunology, 2021
Post-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling.
Junghwa Seo, Junghwa Seo, Yun Soo Park, Yun Soo Park, Tae Hyun Kweon, Tae Hyun Kweon, Jingu Kang, Jingu Kang, Seongjin Son, Seongjin Son, Han Byeol Kim, Yu Ri Seo, Min Jueng Kang, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Jin-Hong Kim, Jin-Hong Kim, Boyoun Park, Boyoun Park, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +24 more
doaj   +1 more source

Association of Metabolomic Change and Treatment Response in Patients with Non-Alcoholic Fatty Liver Disease

Biomedicines, 2022
Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease, yet cost-effective and non-invasive diagnostic tools to monitor the severity of the disease are lacking.
Kwang Seob Lee, Yongin Cho, Hongkyung Kim, Hyunkyeong Hwang, Jin Won Cho, Yong-ho Lee, Sang-Guk Lee   +6 more
doaj   +1 more source

Characterization of glycosylation regulator-mediated glycosylation modification patterns and tumor microenvironment infiltration in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Previous studies have shown that glycosylation of proteins ofen plays an important role in HCC. However, the potential mechanism of glycosylation in HCC has not been described systematically.Methods: We comprehensively evaluated the ...
Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Yang Guo, Yang Guo, Yang Guo, Yang Guo, Zhanfeng Liu, Jing Ma, Yanfeng Peng, Dejun Zhang, Dejun Zhang   +13 more
doaj   +1 more source

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

iScience, 2023
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth   +8 more
doaj   +1 more source

Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites

Biomolecules, 2020
The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved in protein interactions.
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnès Germot, Sébastien Legardinier   +6 more
doaj   +1 more source