Results 1 to 10 of about 183,433 (148)

Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers [PDF]

Alzheimer’s Research & Therapy
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites; however, the impact and function of this glycosylation on
Dobrin Nedelkov, Zoe E. Tsokolas, Matheus Scarpatto Rodrigues, Isabel Sible, S. Duke Han, Bilal E. Kerman, Michael Renteln, Wendy J. Mack, Tharick A. Pascoal, Hussein N. Yassine, the Alzheimer’s Disease Neuroimaging Initiative   +10 more
doaj   +2 more sources

Glycosylation of canine tetherin is essential for its antiviral activity against H3N2 canine influenza virus [PDF]

Frontiers in Veterinary Science
Tetherin is an interferon-induced-expressing transmembrane protein that utilizes a unique topology to restrict the release of enveloped viruses from the surface of the cell membrane.
Liang Xu, Liang Xu, Yuwen Hou, Yuwen Hou, Shizhe Liu, Shizhe Liu, Yixin Dai, Yixin Dai, Jiajun Ou, Jiajun Ou, Shaotang Ye, Shaotang Ye, Zhen Wang, Zhen Wang, Gang Lu, Gang Lu, Shoujun Li, Shoujun Li   +17 more
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O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis

Frontiers in Immunology, 2023
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Junghwa Seo, Yeolhoe Kim, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Hyeryeon Jung, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Injae Shin, Injae Shin, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +16 more
doaj   +1 more source

Role of Sialyl-O-Acetyltransferase CASD1 on GD2 Ganglioside O-Acetylation in Breast Cancer Cells

Cells, 2021
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer.
Sumeyye Cavdarli, Larissa Schröter, Malena Albers, Anna-Maria Baumann, Dorothée Vicogne, Jean-Marc Le Doussal, Martina Mühlenhoff, Philippe Delannoy, Sophie Groux-Degroote   +8 more
doaj   +1 more source

O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity

Frontiers in Immunology, 2021
Post-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling.
Junghwa Seo, Junghwa Seo, Yun Soo Park, Yun Soo Park, Tae Hyun Kweon, Tae Hyun Kweon, Jingu Kang, Jingu Kang, Seongjin Son, Seongjin Son, Han Byeol Kim, Yu Ri Seo, Min Jueng Kang, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Jin-Hong Kim, Jin-Hong Kim, Boyoun Park, Boyoun Park, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +24 more
doaj   +1 more source

Association of Metabolomic Change and Treatment Response in Patients with Non-Alcoholic Fatty Liver Disease

Biomedicines, 2022
Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease, yet cost-effective and non-invasive diagnostic tools to monitor the severity of the disease are lacking.
Kwang Seob Lee, Yongin Cho, Hongkyung Kim, Hyunkyeong Hwang, Jin Won Cho, Yong-ho Lee, Sang-Guk Lee   +6 more
doaj   +1 more source

Characterization of glycosylation regulator-mediated glycosylation modification patterns and tumor microenvironment infiltration in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Previous studies have shown that glycosylation of proteins ofen plays an important role in HCC. However, the potential mechanism of glycosylation in HCC has not been described systematically.Methods: We comprehensively evaluated the ...
Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Yang Guo, Yang Guo, Yang Guo, Yang Guo, Zhanfeng Liu, Jing Ma, Yanfeng Peng, Dejun Zhang, Dejun Zhang   +13 more
doaj   +1 more source

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

iScience, 2023
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth   +8 more
doaj   +1 more source

Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites

Biomolecules, 2020
The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved in protein interactions.
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnès Germot, Sébastien Legardinier   +6 more
doaj   +1 more source

Patient reported outcomes for phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG): listening to what matters for the patients and health professionals

Orphanet Journal of Rare Diseases, 2022
Background Congenital disorders of glycosylation (CDG) are a growing group of rare genetic disorders. The most common CDG is phosphomannomutase 2 (PMM2)-CDG which often has a severe clinical presentation and life-limiting consequences.
C. Pascoal, I. Ferreira, C. Teixeira, E. Almeida, A. Slade, S. Brasil, R. Francisco, A. N. Ligezka, E. Morava, H. Plotkin, J. Jaeken, P. A. Videira, L. Barros, V. dos Reis Ferreira   +13 more
doaj   +1 more source