Results 1 to 10 of about 357,645 (405)

Transcriptomics as a predictor of biopharmaceutically favourable glycan profiles [PDF]

Frontiers in Cell and Developmental Biology
N-glycosylation plays a crucial role in defining the pharmacological properties and efficacy of therapeutic proteins, commonly referred to as biologics. The inherent complexity and lack of a templated process in glycosylation leads to a wide variation in
Ben West, Pavlos Kotidis, Alena Istrate, Daniele Perna, Gary Finka, A. Jamie Wood, A. Jamie Wood, Daniel Ungar   +7 more
doaj   +2 more sources

O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis

Frontiers in Immunology, 2023
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Junghwa Seo, Yeolhoe Kim, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Hyeryeon Jung, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Injae Shin, Injae Shin, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +16 more
doaj   +1 more source

Role of Sialyl-O-Acetyltransferase CASD1 on GD2 Ganglioside O-Acetylation in Breast Cancer Cells

Cells, 2021
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer.
Sumeyye Cavdarli, Larissa Schröter, Malena Albers, Anna-Maria Baumann, Dorothée Vicogne, Jean-Marc Le Doussal, Martina Mühlenhoff, Philippe Delannoy, Sophie Groux-Degroote   +8 more
doaj   +1 more source

O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity

Frontiers in Immunology, 2021
Post-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling.
Junghwa Seo, Junghwa Seo, Yun Soo Park, Yun Soo Park, Tae Hyun Kweon, Tae Hyun Kweon, Jingu Kang, Jingu Kang, Seongjin Son, Seongjin Son, Han Byeol Kim, Yu Ri Seo, Min Jueng Kang, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Jin-Hong Kim, Jin-Hong Kim, Boyoun Park, Boyoun Park, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +24 more
doaj   +1 more source

Characterization of glycosylation regulator-mediated glycosylation modification patterns and tumor microenvironment infiltration in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Previous studies have shown that glycosylation of proteins ofen plays an important role in HCC. However, the potential mechanism of glycosylation in HCC has not been described systematically.Methods: We comprehensively evaluated the ...
Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Yang Guo, Yang Guo, Yang Guo, Yang Guo, Zhanfeng Liu, Jing Ma, Yanfeng Peng, Dejun Zhang, Dejun Zhang   +13 more
doaj   +1 more source

Association of Metabolomic Change and Treatment Response in Patients with Non-Alcoholic Fatty Liver Disease

Biomedicines, 2022
Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease, yet cost-effective and non-invasive diagnostic tools to monitor the severity of the disease are lacking.
Kwang Seob Lee, Yongin Cho, Hongkyung Kim, Hyunkyeong Hwang, Jin Won Cho, Yong-ho Lee, Sang-Guk Lee   +6 more
doaj   +1 more source

Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites

Biomolecules, 2020
The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved in protein interactions.
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnès Germot, Sébastien Legardinier   +6 more
doaj   +1 more source

Patient reported outcomes for phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG): listening to what matters for the patients and health professionals

Orphanet Journal of Rare Diseases, 2022
Background Congenital disorders of glycosylation (CDG) are a growing group of rare genetic disorders. The most common CDG is phosphomannomutase 2 (PMM2)-CDG which often has a severe clinical presentation and life-limiting consequences.
C. Pascoal, I. Ferreira, C. Teixeira, E. Almeida, A. Slade, S. Brasil, R. Francisco, A. N. Ligezka, E. Morava, H. Plotkin, J. Jaeken, P. A. Videira, L. Barros, V. dos Reis Ferreira   +13 more
doaj   +1 more source

Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function

Biomedicines, 2022
Glycosylation is a fundamental cellular process affecting human development and health. Complex machinery establishes the glycan structures whose heterogeneity provides greater structural diversity than other post-translational modifications.
Daniel Sobral, Rita Francisco, Laura Duro, Paula Alexandra Videira, Ana Rita Grosso   +4 more
doaj   +1 more source

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The novel SARS-CoV-2 coronavirus that is responsible for the global pandemic contains a unique insertion of four amino acids within the spike protein (S).
Liping Zhang, Matthew Mann, Zulfeqhar A. Syed, H. Reynolds, E. Tian, N. Samara, D. Zeldin, L. Tabak, K. T. Ten Hagen   +8 more
semanticscholar   +1 more source