Results 21 to 30 of about 175,061 (321)
Aggregate, Volume 3, Issue 6, December 2022., 2022 Investigation of how the AIE molecules and functionalized AIE nanoparticle impact protein stability, protein homeostasis in cells, biodistribution, and biocompatibility in animal model. Abstract Aggregation‐induced emission (AIE) materials offer promising perspectives in disease diagnosis and therapeutics given their unique optical and photochemical ...
Wang Wan +12 more
wiley +1 more source
Ridge Regression Estimated Linear Probability Model Predictions of O-glycosylation in Proteins with Structural and Sequence Data [PDF]
BMC Molecular and Cell Biology 2019, 2018 The likelihood of O-GlcNAc glycosylation in human proteins is predicted using the ridge regression estimated linear probability model (LPM). To achieve this, sequences from three similar post-translational modifications (PTMs) of proteins occurring at, or very near, the S or T site are analyzed: N-glycosylation, O-mucin type (O-GalNAc) glycosylation ...
arxiv +1 more source
Glycosylation and behavioral symptoms in neurological disorders
Translational Psychiatry, 2023 Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is a complex post-translational modification that plays a crucial role in cellular function.
Prajitha Pradeep +2 more
doaj +1 more source
Centralized Modularity of N-Linked Glycosylation Pathways in Mammalian Cells [PDF]
PLoS ONE 4, e7317 (2009), 2009 Glycosylation is a highly complex process to produce a diverse repertoire of cellular glycans that are attached to proteins and lipids. Glycans are involved in fundamental biological processes, including protein folding and clearance, cell proliferation and apoptosis, development, immune responses, and pathogenesis. One of the major types of glycans, N-
arxiv +1 more source
Fluorine‐Directed Automated Mannoside Assembly
Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023 Motivated by the importance of fluorination in drug discovery, fluorine‐directed automated glycan assembly (AFGA) is disclosed. This strategy leverages the C(sp3)−F bond at C2 to enable α‐stereocontrolled glycosylation that eliminates the reliance on O‐based directing groups.
Charlotte S. Teschers, Ryan Gilmour
wiley +1 more source
Glycosyl Formates: Glycosylations with Neighboring-Group Participation [PDF]
Molecules, 2022 Protected 2-O-benzyolated glycosyl formates were synthesized in one-step from the corresponding orthoester using formic acid as the sole reagent. Glucopyranosyl, mannopyranosyl and galactopyranosyl donors were synthesized and their glycosylation properties studied using model glycosyl acceptors of varied steric bulk and reactivity. Bismuth triflate was
Liang Yang, Christian Marcus Pedersen
openaire +4 more sources
Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite ...
Gerwig, G.J. +4 more
openaire +6 more sources
Glycosylation site alteration in the evolution of influenza A (H1N1) viruses. [PDF]
PLoS ONE, 2011 Influenza virus typically alters protein glycosylation in order to escape immune pressure from hosts and hence to facilitate survival in different host environments.
Shisheng Sun +4 more
doaj +1 more source
Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
Cells, 2021 The Golgi is the central organelle of the secretory pathway and it houses the majority of the glycosylation machinery, which includes glycosylation enzymes and sugar transporters. Correct compartmentalization of the glycosylation machinery is achieved by
Zinia D’Souza +3 more
doaj +1 more source
A natural ionic liquid: low molecular mass compounds of aggregate glue droplets on spider orb webs [PDF]
, 2022 The aggregate glue of spider orb web is an excellent natural adhesive. Orb-weaver spiders use micron-scale aggregate glue droplets to retain prey in the capture spiral silks of their orb web. In aggregate glue droplets, highly glycosylated and phosphorylated proteins dissolve in low molecular mass compounds.
arxiv +1 more source