Results 21 to 30 of about 406,798 (331)

N-Glycosylation and Inflammation; the Not-So-Sweet Relation

Frontiers in Immunology, 2022
Chronic inflammation is the main feature of many long-term inflammatory diseases such as autoimmune diseases, metabolic disorders, and cancer. There is a growing number of studies in which alterations of N-glycosylation have been observed in many ...
Barbara Radovani, I. Gudelj
semanticscholar   +1 more source

Characterization of glycosylation regulator-mediated glycosylation modification patterns and tumor microenvironment infiltration in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Previous studies have shown that glycosylation of proteins ofen plays an important role in HCC. However, the potential mechanism of glycosylation in HCC has not been described systematically.Methods: We comprehensively evaluated the ...
Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Linlin Zhao, Yang Guo, Yang Guo, Yang Guo, Yang Guo, Zhanfeng Liu, Jing Ma, Yanfeng Peng, Dejun Zhang, Dejun Zhang   +13 more
doaj   +1 more source

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

iScience, 2023
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth   +8 more
doaj   +1 more source

The glycosylation in SARS-CoV-2 and its receptor ACE2

Signal Transduction and Targeted Therapy, 2021
Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 235 million individuals and led to more than 4.8 million deaths worldwide as of October 5 2021.
Yanqiu Gong, Suideng Qin, Lunzhi Dai, Z. Tian   +3 more
semanticscholar   +1 more source

Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites

Biomolecules, 2020
The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved in protein interactions.
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnès Germot, Sébastien Legardinier   +6 more
doaj   +1 more source

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]

, 2010
Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Brockington, M, Brown, SC, Cirak, S, Liu, K, Muntoni, F, Sharp, PS, Torelli, S, Wells, DJ   +7 more
core   +15 more sources

Patient reported outcomes for phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG): listening to what matters for the patients and health professionals

Orphanet Journal of Rare Diseases, 2022
Background Congenital disorders of glycosylation (CDG) are a growing group of rare genetic disorders. The most common CDG is phosphomannomutase 2 (PMM2)-CDG which often has a severe clinical presentation and life-limiting consequences.
C. Pascoal, I. Ferreira, C. Teixeira, E. Almeida, A. Slade, S. Brasil, R. Francisco, A. N. Ligezka, E. Morava, H. Plotkin, J. Jaeken, P. A. Videira, L. Barros, V. dos Reis Ferreira   +13 more
doaj   +1 more source

Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function

Biomedicines, 2022
Glycosylation is a fundamental cellular process affecting human development and health. Complex machinery establishes the glycan structures whose heterogeneity provides greater structural diversity than other post-translational modifications.
Daniel Sobral, Rita Francisco, Laura Duro, Paula Alexandra Videira, Ana Rita Grosso   +4 more
doaj   +1 more source

Differential Effects of D-Galactose Supplementation on Golgi Glycosylation Defects in TMEM165 Deficiency

Frontiers in Cell and Developmental Biology, 2022
Glycosylation is a ubiquitous and universal cellular process in all domains of life. In eukaryotes, many glycosylation pathways occur simultaneously onto proteins and lipids for generating a complex diversity of glycan structures.
Zoé Durin, Marine Houdou, Willy Morelle, Lydia Barré, Aurore Layotte, Dominique Legrand, Mohamed Ouzzine, François Foulquier   +7 more
doaj   +1 more source

FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

Nature Communications, 2021
Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein.
Yun Huang, Hai-Liang Zhang, Zhi-Ling Li, Tian Du, Yu-Hong Chen, Yan Wang, Huan-he Ni, Kaiming Zhang, Jia Mai, Bingshuang Hu, Junhao Huang, L. Zhou, Dong-dong Yang, Xiao-dan Peng, G. Feng, Jun Tang, Xiao-Feng Zhu, R. Deng   +17 more
semanticscholar   +1 more source