Results 21 to 30 of about 347,689 (338)

Glycosylation modification patterns reveal distinct tumor metabolism and immune microenvironment landscape in lower-grade gliomas

Frontiers in Cell and Developmental Biology, 2022
Glycosylation alterations, a key driver throughout tumorigenesis and tumor progression, could regulate the microenvironment and immune response as well as lead to harmful metabolism and cell signaling.
Guihua Tang, Liming Tan, Hao Yuan, Wen Yin   +3 more
doaj   +1 more source

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum [PDF]

, 2015
The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point mutations that alter its conformational stability, leading to a neurodegenerative dementia called familial encephalopathy with neuroserpin inclusion bodies (FENIB ...
Dalton, Lucy, Gooptu, Bibek, GUADAGNO, NOEMI ANTONELLA, Irving, James A, Lomas, David A, LUPO, GIUSEPPE, Manno, Mauro, Marciniak, Stefan J, Martorana, Vincenzo, MIRANDA BANOS, MARIA ELENA, MORICONI, CLAUDIA, Noto, Rosina, Ordoñez, Adriana, Timpano, Valentina   +13 more
core   +3 more sources

Patient and observer reported outcome measures to evaluate health-related quality of life in inherited metabolic diseases: a scoping review

Orphanet Journal of Rare Diseases, 2018
Background Health-related Quality of Life (HrQoL) is a multidimensional measure, which has gained clinical and social relevance. Implementation of a patient-centred approach to both clinical research and care settings, has increased the recognition of ...
Carlota Pascoal, Sandra Brasil, Rita Francisco, Dorinda Marques-da-Silva, Agnes Rafalko, Jaak Jaeken, Paula A. Videira, Luísa Barros, Vanessa dos Reis Ferreira   +8 more
doaj   +1 more source

Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies

Frontiers in Microbiology, 2021
Glycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions.
Liubov Yakovlieva, Julius A. Fülleborn, Marthe T. C. Walvoort   +2 more
doaj   +1 more source

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

Structure analysis of biologically important prokaryotic glycopolymers [PDF]

, 2013
Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria, Ventura, Valeria Victoria   +1 more
core   +1 more source

Mucin glycosylation and sulphation in airway epithelial cells is not influenced by cystic fibrosis transmembrane conductance regulator expression [PDF]

, 2005
Abnormalities in mucus properties and clearance make a major contribution to the pathology of cystic fibrosis (CF). Our aim was to test the hypothesis that the defects in CF mucus are a direct result of mutations in the CF transmembrane conductance ...
Dell, Anne, Evans, Joanne, Harris, Ann, Leir, Shih-Hsing, Morris, Howard R, Palmai-Pallag, Timea, Parry, Simon   +6 more
core   +1 more source

Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior. [PDF]

, 2014
An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity.
An, Hyun Joo, Bereuter, Thomas L, Dimapasoc, Lauren, Garrido, Daniel, Grimm, Rudolf, Kim, Bum Jin, Kim, Jae-Han, Lebrilla, Carlito B, Mills, David A, Ozcan, Sureyya, Reiter, Christian, Ro, Grace   +11 more
core   +1 more source

Glycosylation of HDL-Associated Proteins and Its Implications in Cardiovascular Disease Diagnosis, Metabolism and Function

Frontiers in Cardiovascular Medicine, 2022
High-density lipoprotein (HDL) particles, long known for their critical role in the prevention of cardiovascular disease (CVD), were recently identified to carry a wide array of glycosylated proteins, and the importance of this glycosylation in the ...
Eduardo Z. Romo, Angela M. Zivkovic
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources