Results 31 to 40 of about 380,786 (407)

Involvement of ST6Gal I‐mediated α2,6 sialylation in myoblast proliferation and differentiation

FEBS Open Bio, 2020
Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers.
Caroline Vergé, Amel Bouchatal, Frédéric Chirat, Yann Guérardel, Abderrahman Maftah, Jean‐Michel Petit   +5 more
doaj   +1 more source

Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies

Frontiers in Microbiology, 2021
Glycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions.
Liubov Yakovlieva, Julius A. Fülleborn, Marthe T. C. Walvoort   +2 more
doaj   +1 more source

Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics

Molecules, 2023
Glycosylation is a critical quality attribute in biotherapeutics, impacting properties such as protein stability, solubility, clearance rate, efficacy, immunogenicity, and safety.
Renato Mastrangeli, Abhijeet Satwekar, Horst Bierau   +2 more
doaj   +1 more source

IgA subclasses have different effector functions associated with distinct glycosylation profiles

Nature Communications, 2020
Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoimmune diseases, but the regulation of serum IgA effector functions is not well defined.
U. Steffen, C. Koeleman, M. Sokolova, H. Bang, A. Kleyer, J. Rech, H. Unterweger, M. Schicht, F. Garreis, J. Hahn, F. Andes, F. Hartmann, M. Hahn, Aparna Mahajan, F. Paulsen, M. Hoffmann, G. Lochnit, L. Munoz, M. Wuhrer, D. Falck, M. Herrmann, G. Schett   +21 more
semanticscholar   +1 more source

Glycosylation modification patterns reveal distinct tumor metabolism and immune microenvironment landscape in lower-grade gliomas

Frontiers in Cell and Developmental Biology, 2022
Glycosylation alterations, a key driver throughout tumorigenesis and tumor progression, could regulate the microenvironment and immune response as well as lead to harmful metabolism and cell signaling.
Guihua Tang, Liming Tan, Hao Yuan, Wen Yin   +3 more
doaj   +1 more source

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I, Kontoravdi, C, Polizzi, K   +2 more
core   +1 more source

Analysis of N-Glycosylation Sites in HIV glycoprotein 160 [PDF]

, 2011
HIV infection is a condition caused by the human immunodeficiency virus. The condition gradually destroys the immune system, which makes it harder for the body to fight infections. HIV presents a complex knot for scientists to unravel.
Rajendra Mandage
core   +2 more sources

Patient and observer reported outcome measures to evaluate health-related quality of life in inherited metabolic diseases: a scoping review

Orphanet Journal of Rare Diseases, 2018
Background Health-related Quality of Life (HrQoL) is a multidimensional measure, which has gained clinical and social relevance. Implementation of a patient-centred approach to both clinical research and care settings, has increased the recognition of ...
Carlota Pascoal, Sandra Brasil, Rita Francisco, Dorinda Marques-da-Silva, Agnes Rafalko, Jaak Jaeken, Paula A. Videira, Luísa Barros, Vanessa dos Reis Ferreira   +8 more
doaj   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

Nature Network Boston, 2020
The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood.
Hiroko Nagao-Kitamoto, Jhansi L. Leslie, Sho Kitamoto, C. Jin, K. Thomsson, Merritt G. Gillilland, Peter Kuffa, Y. Goto, R. Jenq, Chiharu Ishii, A. Hirayama, Anna M. Seekatz, E. Martens, K. Eaton, J. Kao, S. Fukuda, P. Higgins, N. Karlsson, V. Young, N. Kamada   +19 more
semanticscholar   +1 more source