Results 31 to 40 of about 175,061 (321)
Medical Mycology, 2001 O-Glycosylation in many fungal species is initiated in the endoplasmic reticulum by protein mannosyltransferases (Pmt-proteins), which transfer mannose to serine or threonine residues, and it is completed by mannosyltransferases (Mnt-proteins) in the Golgi.
J F, Ernst, S K, Prill
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New insight into protein glycosylation in the development of Alzheimer’s disease
Cell Death Discovery, 2023 Alzheimer’s disease (AD) is a chronic neurodegenerative disease that seriously endangers the physical and mental health of patients, however, there are still no effective drugs or methods to cure this disease up to now.
Jingwei Zhao, Minglin Lang
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Frontiers in Bioscience-Landmark, 2023 Glycosylation is one of the most common post-translational modifications of proteins across all kingdoms of life. Diverse monosaccharides and polysaccharides can be attached to a range of amino acid residues generating N-glycosylation, O-glycosylation, C-
Riye Lu +4 more
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Quantitative Analyses Reveal Novel Roles for
mBio, 2019 In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid +8 more
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Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis
iScience, 2023 Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang +8 more
doaj
Biomedical Chromatography, Volume 37, Issue 1, January 2023., 2023 Abstract Preterm birth and enteral feeding are two main factors leading to necrotizing enterocolitis (NEC). The metabolomics of preterm infants before and after feeding can provide a basis for the prediction of NEC. Using the method of cross‐sectional study, the mode was established with the serum samples of 19 premature infants at birth and after ...
Fusheng Wang +5 more
wiley +1 more source
ELECTROPHORESIS, 2018 AbstractThe change of cellular glycosylation is one of the key events in malignant transformation and neoplastic progression, and tumor‐related glycosylation alterations are promising targets in both tumor diagnosis and therapy. Both malignant transformation and neoplastic progression are the consequence of gene expression alterations and alterations ...
Krešimir Pavelić +3 more
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Protein G: β‐galactosidase fusion protein for multi‐modal bioanalytical applications
Biotechnology Progress, Volume 38, Issue 6, November/December 2022., 2022 Abstract β‐galactosidase (β‐gal) is one of the most prevalent markers of gene expression. Its activity can be monitored via optical and fluorescence microscopy, electrochemistry, and many other ways after slight modification using protein engineering. Here, we have constructed a chimeric version that incorporates a streptococcal protein G domain at the
Dana Motabar +4 more
wiley +1 more source
Genomic-Glycosylation Aberrations in Tumor Initiation, Progression and Management
AIMS Medical Science, 2016 Post-translation modifications of proteins alter their functional activity and thus are key contributors of tumor initiation and progression. Glycosylation, one of the most common post-translational modifications of proteins, has been associated with ...
Carman K.M. Ip +4 more
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Single-molecule stretching shows glycosylation sets tension in the hyaluronan-aggrecan bottlebrush [PDF]
, 2019 Large bottlebrush complexes formed from the polysaccharide hyaluronan (HA) and the proteoglycan aggrecan contribute to cartilage compression resistance and are necessary for healthy joint function. A variety of mechanical forces act on these complexes in the cartilage extracellular matrix, motivating the need for a quantitative description which links ...
arxiv +1 more source