Results 31 to 40 of about 406,798 (331)

Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics

Molecules, 2023
Glycosylation is a critical quality attribute in biotherapeutics, impacting properties such as protein stability, solubility, clearance rate, efficacy, immunogenicity, and safety.
Renato Mastrangeli, Abhijeet Satwekar, Horst Bierau   +2 more
doaj   +1 more source

Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2

bioRxiv, 2020
The current emergence of the novel coronavirus pandemic caused by SARS-CoV-2 demands the development of new therapeutic strategies to prevent rapid progress of mortalities.
A. Shajahan, N. Supekar, A. Gleinich, P. Azadi   +3 more
semanticscholar   +1 more source

Involvement of ST6Gal I‐mediated α2,6 sialylation in myoblast proliferation and differentiation

FEBS Open Bio, 2020
Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers.
Caroline Vergé, Amel Bouchatal, Frédéric Chirat, Yann Guérardel, Abderrahman Maftah, Jean‐Michel Petit   +5 more
doaj   +1 more source

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

Nature Communications, 2020
Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic potential.
Yasunori Watanabe, Z. Berndsen, J. Raghwani, Gemma E. Seabright, Joel D. Allen, O. Pybus, J. McLellan, I. Wilson, T. Bowden, A. Ward, M. Crispin   +10 more
semanticscholar   +1 more source

Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications

Cells, 2021
Glycans are major constituents of extracellular vesicles (EVs). Alterations in the glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or increased synthesis of particular glycans.
Álvaro M Martins, Cátia C. Ramos, D. Freitas, C. Reis   +3 more
semanticscholar   +1 more source

Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies

Frontiers in Microbiology, 2021
Glycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions.
Liubov Yakovlieva, Julius A. Fülleborn, Marthe T. C. Walvoort   +2 more
doaj   +1 more source

Iron-Catalyzed Highly Stereospecific Glycosylation with Glycal Epoxides. [PDF]

Angew Chem Int Ed Engl
We report an iron‐catalyzed, highly stereospecific glycosylation method with glycal epoxides, which is effective for a broad range of substrates, including previously challenging, sterically hindered secondary acceptors and glucuronic ester epoxide donors.
Zhang XW, Yin L, Zhang D, Jiang Z, Wang P, Xu H.   +5 more
europepmc   +3 more sources

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I, Kontoravdi, C, Polizzi, K   +2 more
core   +1 more source

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The novel SARS-CoV-2 coronavirus that is responsible for the global pandemic contains a unique insertion of four amino acids within the spike protein (S).
Liping Zhang, Matthew Mann, Zulfeqhar A. Syed, H. Reynolds, E. Tian, N. Samara, D. Zeldin, L. Tabak, K. T. Ten Hagen   +8 more
semanticscholar   +1 more source

Glycosylation modification patterns reveal distinct tumor metabolism and immune microenvironment landscape in lower-grade gliomas

Frontiers in Cell and Developmental Biology, 2022
Glycosylation alterations, a key driver throughout tumorigenesis and tumor progression, could regulate the microenvironment and immune response as well as lead to harmful metabolism and cell signaling.
Guihua Tang, Liming Tan, Hao Yuan, Wen Yin   +3 more
doaj   +1 more source