Results 61 to 70 of about 41,434 (212)

A Woman With Hypertriglyceridemia Who Acquired Antibody Against GPIHBP1

JACC: Case Reports, 2020
We report a case of a woman with primary hypertriglyceridemia caused by acquired glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) autoantibody. This case highlights the necessity of detecting GPIHBP1 autoantibody
Yuka Hirano, MD, Yasunori Suematsu, MD, PhD, Yuiko Yano, MD, PhD, Shuichi Sato, MD, PhD, Shin-Ichiro Miura, MD, PhD   +4 more
doaj   +1 more source

Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Nature Communications, 2023
Many eukaryotic receptors and enzymes rely on glycosylphosphatidylinositol (GPI) anchors for membrane localization and function. The transmembrane complex GPI-T recognizes diverse proproteins at a signal peptide region that lacks consensus sequence and ...
Yidan Xu, Tingting Li, Zixuan Zhou, Jingjing Hong, Yulin Chao, Zhini Zhu, Ying Zhang, Qianhui Qu, Dianfan Li   +8 more
doaj   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P., Portelli, Michael A., Sayers, Ian   +2 more
core  

Glycosylphosphatidylinositols: More than just an anchor? [PDF]

, 2016
There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Bate, C, Nolan, W, Williams, A
core   +1 more source

Chemical Synthesis of Glycosylphosphatidylinositol Anchors [PDF]

, 2012
Many eukaryotic cell-surface proteins and glycoproteins are anchored to the plasma membrane by glycosylphosphatidylinositols (GPIs), a family of glycolipids that are post-translationally attached to proteins at their C-termini. GPIs and GPI-anchored proteins play important roles in many biological and pathological events, such as cell recognition and ...
Benjamin M, Swarts, Zhongwu, Guo
openaire   +2 more sources

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

GPIomics: global analysis of glycosylphosphatidylinositol‐anchored molecules of Trypanosoma cruzi

Molecular Systems Biology, 2009
Glycosylphosphatidylinositol (GPI) anchoring is a common, relevant posttranslational modification of eukaryotic surface proteins. Here, we developed a fast, simple, and highly sensitive (high attomole‐low femtomole range) method that uses liquid ...
Ernesto S Nakayasu, Dmitry V Yashunsky, Lilian L Nohara, Ana Claudia T Torrecilhas, Andrei V Nikolaev, Igor C Almeida   +5 more
doaj   +1 more source

Hypotonia and intellectual disability without dysmorphic features in a patient with PIGN-related disease

BMC Medical Genetics, 2017
Background Defects in the human glycosylphosphatidylinositol anchor biosynthetic pathway are associated with inherited glycosylphosphatidylinositol (GPI)-deficiencies characterized by a broad range of clinical phenotypes including multiple congenital ...
Isabelle Thiffault, Britton Zuccarelli, Holly Welsh, Xuan Yuan, Emily Farrow, Lee Zellmer, Neil Miller, Sarah Soden, Ahmed Abdelmoity, Robert A. Brodsky, Carol Saunders   +10 more
doaj   +1 more source

Deletions in CWH43 cause idiopathic normal pressure hydrocephalus

EMBO Molecular Medicine, 2021
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder that occurs in about 1% of individuals over age 60 and is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and cognitive decline.
Hong Wei Yang, Semin Lee, Dejun Yang, Huijun Dai, Yan Zhang, Lei Han, Sijun Zhao, Shuo Zhang, Yan Ma, Marciana F Johnson, Anna K Rattray, Tatyana A Johnson, George Wang, Shaokuan Zheng, Rona S Carroll, Peter J Park, Mark D Johnson   +16 more
doaj   +1 more source

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]

, 2010
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A., Jacobs, J.G., Keulen, L.J.M., van, Langeveld, J.P.M., Sauer, M., Tang, Y.   +5 more
core   +2 more sources