Results 1 to 10 of about 1,482 (86)

The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis [PDF]

mBio
Glycosylphosphatidylinositols (GPIs) are highly conserved anchors for eukaryotic cell surface proteins. The apicomplexan parasite, Toxoplasma gondii, is a widespread intracellular parasite of warm-blooded animals whose plasma membrane is covered with GPI-
Julia A. Alvarez, Elisabet Gas-Pascual, Sahil Malhi, Juan C. Sánchez-Arcila, Ferdinand Ngale Njume, Hanke van der Wel, Yanlin Zhao, Laura García-López, Gabriella Ceron, Jasmine Posada, Scott P. Souza, George S. Yap, Christopher M. West, Kirk D. C. Jensen   +13 more
doaj   +2 more sources

Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages. [PDF]

PLoS ONE, 2014
Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a detrimental stimulation of the host innate immune system aside their main function to anchor surface proteins.
Sebastian Niehus, Terry K Smith, Nahid Azzouz, Marco A Campos, Jean-François Dubremetz, Ricardo T Gazzinelli, Ralph T Schwarz, Françoise Debierre-Grockiego   +7 more
doaj   +1 more source

Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity. [PDF]

PLoS ONE, 2014
Insulin-mimetic species of low molecular weight are speculated to mediate some intracellular insulin actions. These inositol glycans, which are generated upon insulin stimulation from glycosylphosphatidylinositols, might control the activity of a ...
Susumu Suzuki, Chitose Suzuki, Yoshinori Hinokio, Yasushi Ishigaki, Hideki Katagiri, Makoto Kanzaki, Viatcheslav N Azev, Nilanjana Chakraborty, Marc d'Alarcao   +8 more
doaj   +1 more source

Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes

Orphanet Journal of Rare Diseases, 2020
Background Defects in the glycosylphosphatidylinositol (GPI) biosynthesis pathway can result in a group of congenital disorders of glycosylation known as the inherited GPI deficiencies (IGDs).
Leigh C. Carmody, Hannah Blau, Daniel Danis, Xingman A. Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D. Thompson, Peter N. Robinson   +8 more
doaj   +1 more source

Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage

Biology, 2015
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons.
Ewan West, Craig Osborne, William Nolan, Clive Bate   +3 more
doaj   +1 more source

A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry Biogenesis and Virulence

mSphere, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Nathan M. Chasen, Beejan Asady, Leandro Lemgruber, Rossiane C. Vommaro, Jessica C. Kissinger, Isabelle Coppens, Silvia N. J. Moreno   +6 more
doaj   +1 more source

Alkylacylglycerolipid domain of GPI molecules of Leishmania is responsible for inhibition of PKC-mediated c-fos expression

Journal of Lipid Research, 2003
Glycosylphosphatidylinositols (GPIs) are the most abundant molecules present in the membranes of the parasitic protozoa Leishmania responsible for multiple forms of leishmaniasis.
Mamta Chawla, Ram A. Vishwakarma
doaj   +1 more source

Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus

Journal of Fungi, 2018
Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall polymers.
Jizhou Li, Isabelle Mouyna, Christine Henry, Frédérique Moyrand, Christian Malosse, Julia Chamot-Rooke, Guilhem Janbon, Jean-Paul Latgé, Thierry Fontaine   +8 more
doaj   +1 more source

Glycosylphosphatidylinositols: More than just an anchor?

Communicative & Integrative Biology, 2016
There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Clive Bate, William Nolan, Alun Williams
doaj   +1 more source

Thematic Review Series: Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Journal of Lipid Research, 2016
Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine ...
Taroh Kinoshita, Morihisa Fujita
doaj   +1 more source