Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides [PDF]
ACS Chemical Biology, 2021 The attachment of proteins to the cell membrane using a glycosylphosphatidylinositol (GPI) anchor is a ubiquitous process in eukaryotic cells. Deficiencies in the biosynthesis of GPIs and the concomitant production of GPI-anchored proteins lead to a series of rare and complicated disorders associated with inherited GPI deficiencies (IGDs) in humans ...
Paula A. Guerrero +5 more
openaire +3 more sources
Trypanosome Glycosylphosphatidylinositol Biosynthesis [PDF]
The Korean Journal of Parasitology, 2009 Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins.
Yeonchul, Hong, Taroh, Kinoshita
openaire +2 more sources
Glycosylphosphatidylinositols: More than just an anchor? [PDF]
, 2016 There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Bate, C, Nolan, W, Williams, A
core +1 more source
Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß [PDF]
, 2017 Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to ...
Bate, C
core +3 more sources
Cellules natural killer et immunité innée contre le paludisme [PDF]
, 2006 La réponse immunitaire dirigée contre Plasmodium falciparum (Pf), agent responsable du paludisme chez l’homme, est le résultat de plusieurs milliers d’années de co-évolution entre le parasite et son hôte.
Baratin, Myriam +3 more
core +1 more source
Monoacylated Cellular Prion Proteins Reduce Amyloid-beta-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage [PDF]
, 2015 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons.
Caughey +9 more
core +2 more sources
Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in malaria pathology [PDF]
, 2017 Glycosylphosphatidylinositol (GPI) anchor of Plasmodium falciparum origin is considered an important toxin leading to severe malaria pathology through stimulation of pro-inflammatory responses from innate immune cells.
Amar +62 more
core +2 more sources
Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation [PDF]
, 2012 Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the ...
Eva Greganova +5 more
core +4 more sources
Worldwide malaria incidence and cancer mortality are inversely associated [PDF]
, 2018 BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children.
Liu, P.
core +1 more source
Untersuchungen zur Topologie der Glycosylphosphatidylinositol-Biosynthese in Toxoplasma gondii [PDF]
, 2004 Toxoplasma gondii ist ein obligat intrazellulär lebendes, parasitisches Protozoon mit großer medizinischer Bedeutung vor allem in zwei Fällen: Zum einen bei Erstinfektion während einer Schwangerschaft, hier kann es zur Schädigung des Fötus kommen, zum ...
Kimmel, Jürgen +1 more
core +1 more source