Results 91 to 100 of about 26,147 (300)

Glycoengineering strategies for constructing defined Mucin O-glycans

Frontiers in Molecular Biosciences
Mucins are densely O-glycosylated proteins that establish mucosal barriers, mediate immune recognition, and serve as ligands for host lectins and microbes.
Thapakorn Jaroentomeechai, Thapakorn Jaroentomeechai, Matthew Phanchana, Kornchanok Jaiboon, Kornchanok Jaiboon, Thanapong Kruangkum, Thanapong Kruangkum   +6 more
doaj   +1 more source

Natural product C-glycosyltransferases - a scarcely characterised enzymatic activity with biotechnological potential

, 2021
Covering: up to 2020C-Glycosyltransferases are enzymes that catalyse the transfer of sugar molecules to carbon atoms in substituted aromatic rings of a variety of natural products.
Welner, Ditte Hededam, Fredslund, Folmer, Tezé, David, Putkaradze, Natalia   +3 more
core   +1 more source

Direct interaction between MreB and the RodA‐PBP2 complex organizes lateral cell wall synthesis in Escherichia coli

mLife, EarlyView.
Abstract The elongasome, or the Rod complex, orchestrates lateral peptidoglycan (PG) synthesis in many rod‐shaped bacteria. It consists of the actin‐like protein MreB, the PG synthase RodA‐PBP2 complex, as well as MreCD and RodZ. Although the loss or disruption of any elongasome component results in a loss of rod shape, previous studies found that a ...
Rui Zhan, Han Gong, Ying Li, Xiangdong Chen, Joe Lutkenhaus, Shishen Du   +5 more
wiley   +1 more source

ABO gene polymorphisms: a molecular bridge linking disease susceptibility to therapeutic outcomes

Frontiers in Medicine
ABO blood group antigens represent more than surface markers on red blood cells. They are pivotal genetic determinants that affect susceptibility to various diseases and variations in drug response.
Shaoqing Yin, Shaoqing Yin, Shaoqing Yin, Jiaye Li, Jiaye Li, Wei Zhang, Wei Zhang, Wei Zhang, Rui Ding, Yan Li, Kai Wang, Wenjian Jiang, Wenjian Jiang, Yi-Da Tang, Yi-Da Tang, Yi-Da Tang, Zhengjun Yi, Yaohua Zhang, Yaohua Zhang, Meng Li   +19 more
doaj   +1 more source

The N‐Glycome to Differentiate Mesenchymal Stem Cells Upon Chondrogenic Differentiation, Dedifferentiation, and Senescence

PROTEOMICS, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) are adult stem cells able to self‐renewal or differentiation into different cell types, including chondrocytes. N‐Glycans are post‐translational modifications of glycoproteins that contribute to vital cell functions.
Houda Montacir, Karina Biskup, Michael Sittinger, Rudolf Tauber, Véronique Blanchard   +4 more
wiley   +1 more source

Trapping and retaining intermediates in glycosyltransferases

, 2023
Glycosyltransferases (GTs) attach sugar molecules to a broad range of acceptors, generating a remarkable amount of structural diversity in biological systems. GTs are classified as either “retaining” or “inverting” enzymes.
Marcelo E. Guerin, Guerin, Marcelo E.
core   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

A Systematic Investigation of the Synthetic Utility of Glycopeptide Glycosyltransferases

, 2016
Glycosyltransferases involved in the biosynthesis of bacterial secondary metabolites may be useful for the generation of sugar-modified analogues of bioactive natural products. Some glycosyltransferases have relaxed substrate specificity, and it has been
Catherine Leimkuhler (2478820), Christopher T. Walsh (1265718), Markus Oberthür (2452474), Ryan G. Kruger (2013604), Daniel Kahne (1281306), Wei Lu (3580)   +5 more
core   +1 more source

Unique motifs identify PIG-A proteins from glycosyltransferases of the GT4 family [PDF]

, 2008
Background The first step of GPI anchor biosynthesis is catalyzed by PIG-A, an enzyme that transfers N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol.
Bhattacharya Alok, Bhattacharya, Alok, Muthuswami Rohini, Oswal Nupur, Komath Sneha, Oswal, Nupur, Sahni, Narinder Singh, Komath, Sneha Sudha, Muthuswami, Rohini, Sahni Narinder   +9 more
core   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source