Results 141 to 150 of about 6,124,437 (230)

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology
Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
doaj   +1 more source

Simvastatin Modulates Astrocyte and Microglial Reactivity and Aggressive Behavior After Chronic Sleep Deprivation in Rats

Journal of Neuroscience Research, Volume 104, Issue 11, November 2026.
Simvastatin modulates chronic sleep deprivation‐induced glial remodeling and behavioral responses. ABSTRACT Chronic sleep deprivation (SD) disrupts central nervous system homeostasis, promoting behavioral alterations and glial remodeling within limbic structures.
Higor Hernany Dias, Kevin Silva Müller, Gabriela Larissa Lima‐da‐Silva, Stephane da Silva Alves, Tatiane de Camargo Martins, Pedro Tadao Hamamoto Filho, José de Anchieta de Castro e Horta‐Júnior   +6 more
wiley   +1 more source

No Glymphatic Dysfunction in Trigeminal Neuralgia: A Preliminary Study

Brain and Behavior
Background Trigeminal neuralgia (TN) patients are at risk for glymphatic dysfunction due to their prolonged headaches and sleep disturbances. Objective The aim of this study is to compare the glymphatic function changes in TN patients with healthy ...
Barış Genç, Kerim Aslan
doaj   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3703-3706, November 2026.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source

High‐Resolution IVIM MRI Characterizes Diffusion–Perfusion Properties of the Parasagittal Dura

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
Parasagittal dura demonstrates intermediate diffusion and elevated perfusion‐related IVIM metrics compared with brain parenchyma, reflecting its unique microfluidic environment at the CSF–dura interface. IVIM imaging of the parasagittal dura provides a rapid, noncontrast MRI approach to assess dural fluid transport and may offer a potential imaging ...
Yi‐Jui Liu, Chun‐Han Liao, Shin‐Lei Peng, Shao‐Chieh Lin, Chao‐Chun Lin, Chia‐Wei Lin, Chia‐Hong Hsieh, Chun‐Wen Chen, Hing‐Chiu Chang   +8 more
wiley   +1 more source

The Vicious Cycle of Sleep Disruption and Inflammaging: Mechanisms, Consequences, and Therapeutic Opportunities

Aging Cell, Volume 25, Issue 11, November 2026.
Sleep disruption and circadian decline drive inflammaging and immune aging via the gut‐brain axis, NLRP3, and TLR4, forming a vicious cycle that accelerates cognitive decline and epigenetic aging. Targeting this sleep‐immune axis offers a viable strategy for promoting healthy longevity. ABSTRACT Aging is characterized by two interdependent hallmarks: a
Fu‐Ying Zhao, Jia‐Mei Wang, Shi‐Yang Lu, Liang Hao, Hai‐Yan Zhang, Hua‐Qin Wang   +5 more
wiley   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, Volume 36, Issue 6, November 2026.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Distribution and target engagement of peripherally administered fremanezumab in the cerebrospinal fluid of healthy volunteers

Headache: The Journal of Head and Face Pain, Volume 66, Issue 10, Page 2305-2316, November/December 2026.
Abstract Objectives/Background Our objective was to describe the distribution of fremanezumab to the cerebrospinal fluid (CSF) in healthy volunteers, and investigate its engagement and stabilization of its target, calcitonin gene‐related peptide (CGRP). Fremanezumab is a CGRP‐targeting monoclonal antibody approved for migraine prevention.
Jacki Rorabaugh, Edward Hellriegel, Juline Bryson, Ryan Tiver, Hang Zeng, Xiaofeng Lu, Steve Barash, Giulia Ghibellini, Olga Szilagyi, Ignacio Echenique, Andrew H. Ahn, Peter J. Goadsby, Laura Rabinovich‐Guilatt   +12 more
wiley   +1 more source