Results 121 to 130 of about 6,124,437 (230)

Hypothalamic Neurochemical and Microglial Suppression in Long‐Standing Human Hibernation‐Like Syndrome

Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.
A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Wei Jiang, Andries Kalsbeek, Roelof A. Hut, Dick F. Swaab, Chun‐Xia Yi   +4 more
wiley   +1 more source

The glymphatic pathway in neurological disorders

, 2018
Background: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain ...
Rasmussen, Martin Kaag, Nedergaard, Maiken, Mestre, Humberto   +2 more
core   +1 more source

Locus coeruleus microstructural integrity and sleep disruption in the context of Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is among the first sites of tau pathology in Alzheimer's disease (AD) and plays a key role in sleep–wake regulation. However, evidence linking LC integrity to objective sleep measures in the context of emerging AD pathology remains limited.
Maxime Van Egroo, Yuliya Patsyuk, Marion Baillet, Nicholas M. Vogt, Andrew S. P. Lim, Nicholas J. Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I. L. Jacobs   +10 more
wiley   +1 more source

The glymphatic system in migraine and other headaches [PDF]

Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial fluid, encompassing penetrating and pial ...
Ketevan Paposhvili, Vittorini, Maria Grazia, Yusifli, Sevil, Aysenur Sahin, Simona Sacco, Antonin Trojan, Christian Lampl, Tischler, Viktoria, Sacco, Simona, Paposhvili, Ketevan, Sevil Yusifli, Gonçalo V. Bonifácio, on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Trojan, Antonin, Lampl, Christian, Alashvili, Tamta, Tamta Alashvili, Bonifácio, Gonçalo V, Viktoria Tischler, Maria Grazia Vittorini, Sahin, Aysenur   +20 more
core   +1 more source

Targeting the Sleep–Glymphatic–Vascular Continuum in Cerebral Small Vessel Disease: A Nutritional Perspective on Neuroprotective Potential of Tocotrienols (T3)

Life
Cerebral small vessel disease (CSVD) is a leading cause of stroke, cognitive impairment, and vascular dementia, yet disease-modifying therapeutic strategies remain limited.
Dena Farysah Mazli, Zaw Myo Hein, Che Mohd Nasril Che Mohd Nassir, Ain Hafizah Alias, Sint Sint Win, Mohammad Farris Iman Leong Abdullah, Muhammad Zulfadli Mehat, Hafizah Abdul Hamid, Gehan El-Akabawy   +8 more
doaj   +1 more source

Age‐linked biological context shapes adaptive immunity in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract Alzheimer's disease (AD) is increasingly recognized as a neuroimmune disorder with protective or pathogenic adaptive immunity dependent on the biological context. This review synthesizes evidence from human studies, genetic analyses, mouse models, and clinical trials to examine how lymphocytes and humoral immunity influence AD.
Sophie Shirenova, Arya Biragyn, Eitan Okun   +2 more
wiley   +1 more source

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Annals of Neurology, Volume 100, Issue 5, Page 1012-1022, November 2026.
Objectives Apolipoprotein E ε4 (APOE ε4), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathway through which ε4 contributes to Alzheimer's disease vulnerability. However,
Gawon Cho, Anne Chen, Eunyoung Choi, Orfeu M. Buxton, Daniel Kay, Adam Mecca, Brienne Miner   +6 more
wiley   +1 more source

Structural and Functional Features of the Glymphatic System: a Contemporary Perspective

Morphology
The aging of the population in developed countries is a trend of major medical and social significance. In this regard, the study of the etiology and pathogenesis of neurodegenerative diseases, as well as the search for effective treatment methods, is of particular relevance.
Lyudmila A. Klyueva, Damir A. Averin, Karina A. Vasyanina   +2 more
openaire   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, Volume 100, Issue 5, Page 1055-1067, November 2026.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms

Aims Smoking significantly impairs cognitive function and is a major risk factor for dementia, particularly when initiated during adolescence, a critical period for brain development.
Yu Qian, Mingqi Liu, Zean Li, Rongcai Jiang, Tao Liu, Zhuang Sha, Chuanxiang Lv, Chengyu Xia, Xinran Zhang, Li Bie, Kang Zhang, Shiying Dong   +11 more
core   +1 more source