Results 111 to 120 of about 6,124,437 (230)

The influence of the glymphatic system on α-synuclein propagation: the role of aquaporin-4 [PDF]

Propagation and aggregation of prion proteins, such as tau and α-synuclein (αSyn), are key pathological features of neurodegenerative diseases. Extracellular clearance pathways, such as the glymphatic system, may play a crucial role in the removal of ...
Wells, Jack A, Verona, Guglielmo, Llewellyn, Sophie K, Gegg, Matthew E, Lythgoe, Mark F, Harrison, Ian F, Wang, Jiazheng, Lopes, Douglas M, Bury, Sheila E   +8 more
core   +1 more source

Cerebral blood flow in conscious rats and implications for therapeutic interventions

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) often becomes compromised in patients suffering from cardiovascular diseases, increasing the risk of neurodegenerative disease and vascular dementia. There is an urgent need for treatments to address cardiovascular risk without compromising brain perfusion, yet the impact of many existing treatments on CBF are not ...
Tonja W. Emans, Courtney R. Brighouse, Jack T. Sloan, Fiona D. McBryde   +3 more
wiley   +1 more source

Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease

iScience
Summary: Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes.
Sunil Koundal, Xinan Chen, Zachary Gursky, Hedok Lee, Kaiming Xu, Feng Liang, Zhongcong Xie, Feng Xu, Hung-Mo Lin, William E. Van Nostrand, Xianfeng Gu, Rena Elkin, Allen Tannenbaum, Helene Benveniste   +13 more
doaj   +1 more source

Thermoregulatory and plasma neurobiomarker responses to heat tolerance assessment in exertional heat illness and matched controls

Experimental Physiology, EarlyView.
Abstract Exercise in the heat and elevated tissue temperature are associated with neuronal stress and changes in blood–brain barrier (BBB) function. More severe thermal insult may manifest as exertional heat illness (EHI) and complication by central nervous system (CNS) dysfunction may persist post‐EHI.
Tom W. Palin, Jo Corbett, Lisa J. Hill, David R. Woods, Alex A. M. Gould, Barney Wainwright, James A. Roberts, Chloe N. Thomas, Daniel Snape, Carol House, Omar Tayari, Richard J. Elsworthy, James L. Mitchell, Andrew J. Roberts, John P. O'Hara, Michael J. Stacey   +15 more
wiley   +1 more source

Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus

, 2020
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles.
Alper, Seth L., Cerci, H. Mert, Kundishora, Adam J., Lundgaard, Iben, Reeves, Benjamin C., Karimy, Jason K., Nedergaard, Maiken, Kahle, Kristopher T., Mestre, Humberto, Matouk, Charles, Reeves, Benjamin C.,, Kahle, Kristopher T.,, Lundgaard, Iben,, Kundishora, Adam J.,, Cerci, H. Mert,, Nedergaard, Maiken,, Alper, Seth L.,, Mestre, Humberto,, Karimy, Jason K.,, ÇERÇİ, HÜSEYİN MERT, Lund University., Matouk, Charles,   +21 more
core   +1 more source

Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
doaj   +1 more source

May Glymphatic Drainage Improve Life Quality in Progressive Multiple Sclerosis Outpatients? [PDF]

Sandro Mandolesi,1 Tarcisio Niglio,2 Chiara Lenci3 1Research Department of the Mediterranean Pole, Technoscience, Science and Technology Park, San Severo, Italy; 2Istituto Superiore di Sanità, Roma, Italy; 3“la Sapienza” University, Roma ...
Lenci C, Mandolesi S, Niglio T
core  

Phase coupling between eye and brain pulsations is bidirectional and modulated by the parasympathetic system – An fMREye study

Acta Ophthalmologica, Volume 104, Issue 8, Page e1028-e1048, December 2026.
Abstract Purpose Physiological pulsations driven by cardiac, respiratory, and vasomotor activity are essential for solute transport within perivascular and perineural cerebrospinal fluid (CSF) pathways that support brain and eye clearance systems. Previous studies have shown that parasympathetic blockade significantly reduces ocular pulsation power and
Ebrahimi Seyed‐Mohsen, Väyrynen Tommi, Huotari Niko, Saarela Ville, Honkamo Marja, Helakari Heta, Järvelä Matti, Korhonen Vesa, Raitamaa Lauri, Kiviniemi Vesa   +9 more
wiley   +1 more source

Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition

Frontiers in Aging Neuroscience
ObjectiveWhile emerging evidence links glymphatic dysfunction to cerebral small vessel disease (CSVD), its clinical relevance remains poorly defined. This study aimed to investigate the relationships among glymphatic function, perivascular space (PVS ...
Lulu Ai, Zhiwei Li, Huipeng Huang, Chaojuan Huang, Shujian Chen, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun   +7 more
doaj   +1 more source

Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex

Neural activity inevitably produces waste, which promotes neurodegeneration with topographic features. The glymphatic system is important for waste clearance.
Xiao Zhu, Jianzhong Sun, Xuting Zhang, Yifei Li, Ziyu Zhou, Kai Wei, Min Lou, Ying Zhou   +7 more
core   +2 more sources