Results 91 to 100 of about 6,124,437 (230)

Phosphorylation of AQP4 by LRRK2 R1441G impairs glymphatic clearance of IFNγ and aggravates dopaminergic neurodegeneration

npj Parkinson's Disease
Aquaporin-4 (AQP4) is essential for normal functioning of the brain’s glymphatic system. Impaired glymphatic function is associated with neuroinflammation.
Heng Huang, Lishan Lin, Tengteng Wu, Cheng Wu, Leping Zhou, Ge Li, Fengjuan Su, Fengyin Liang, Wenyuan Guo, Weineng Chen, Qiuhong Jiang, Yalun Guan, Xuejiao Li, Pingyi Xu, Yu Zhang, Wanli Smith, Zhong Pei   +16 more
doaj   +1 more source

Altered glymphatic function and cerebrovascular reactivity in white matter hyperintensities: Insights into cognitive impairment

Brain Research Bulletin
Objective: White matter hyperintensities (WMH) are linked to cognitive impairment and an increased risk of cerebrovascular and neurodegenerative disorders.
Kai Li, Yueyan Bian, Yi Xing, Xiuqin Jia
doaj   +1 more source

Immunological Roles of Cerebrospinal Fluid

Immunology &Cell Biology, EarlyView.
CSF flows between and connects brain border compartments, enabling them to synchronise immune responses to the needs of the CNS. The CSF is also a permissive environment during neuroinflammation, and immune cells are funnelled towards the CSF through multiple routes in diverse neurological diseases.
Anabelle S. Pasic, Leon C. D. Smyth
wiley   +1 more source

Impaired glymphatic transport in hypoxic-ischemic encephalopathy

NeuroImage
Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal brain injury. The glymphatic system aids in waste clearance via perivascular pathways and is crucial in maintaining brain functions.
Jieyi Shen, Ying Yang, Fangfang Chen, Yang Zuo, Yidong Yang, Wei Wei, Ying Liu, Jie Wen   +7 more
doaj   +1 more source

Elevated Blood Pressure Is Causally Associated With Larger Subcortical Gray Matter Structure Through Perivascular Clearance Routes

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Background This study aimed to investigate the association between elevated blood pressure (BP) and subcortical gray matter structures, and to elucidate the causality and underlying mechanisms. Methods This study enrolled 1012 participants from a multicenter, population‐based cohort study in China.
Jing Sun, Jing Li, Xiaoshuai Li, Xinyu Zhao, Pengfei Zhao, Zhenghan Yang, Shuohua Chen, Shouling Wu, Ying Hui, Zhenchang Wang, Han Lv   +10 more
wiley   +1 more source

Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease

npj Parkinson's Disease
The characteristic asymmetric motor symptoms of Parkinson’s disease (PD) may be associated with asymmetric deposition of α-synuclein. The impaired glymphatic system may promote pathological deposition of α-synuclein, leading to disease progression.
Zihan Li, Xinxin Miao, Qiumei Zhang, Jun Shen, Yongfeng Jia, Shaoyun Ge, Peixian Ji, Jianwei Wang, Kezhong Zhang, Min Wang   +9 more
doaj   +1 more source

Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review

Frontiers in Neurology
The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system (CNS) of vertebrates that exploits the perivascular compartment between the vascular basement membrane (outermost wall of blood vessels) and astrocytic ...
Lichuan Zeng, Lichuan Zeng, Lichuan Zeng, Zihan Yin, Wei Li, Xiao Wang, Yaodan Zhang, Mingguo Xie, Ling Zhao   +8 more
doaj   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Glymphatic system function in diverse glucose metabolism states

World Journal of Diabetes
The rising prevalence of diabetes and prediabetes globally necessitates a deeper understanding of associated complications, including glymphatic system dysfunction. The glymphatic system, crucial for brain waste clearance, is imp-licated in cognitive decline and neurodegenerative diseases like Alzheimer’s disease.
openaire   +2 more sources

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source