Results 81 to 90 of about 6,124,437 (230)

Association of MRI indexes of glymphatic system with brain atrophy and cognitive impairment in cerebral small vessel disease

NeuroImage: Clinical
Background and objective: The glymphatic system constitutes a brain-wide perivascular network responsible for brain metabolic waste removal, which may underlie pathogenesis in cerebral small vessel disease (CSVD).
Lulu Ai, Zhiwei Li, Chaojuan Huang, Xia Zhou, Xiaoqun Zhu, Qiaoqiao Xu, Zhongwu Sun   +6 more
doaj   +1 more source

How About Glymphatic System Function in Patients With Migraine?

, 2021
Abstract Background: There have been no studies evaluating the glymphatic system function in patients with migraine. In this study, we evaluated the alterations in glymphatic system function in patients with migraine compared to healthy controls using a diffusion tensor imaging (DTI) analysis along the perivascular space (DTI-ALPS) method.
Dong Ah Lee, Bong Soo Park, Junghae Ko, Il Hwan Kim, Jin Han Park, Sihyung Park, Yoo Jin Lee, Kang Min Park   +7 more
openaire   +1 more source

The characteristics of perivascular proinflammation in 4‐repeat tauopathies

Brain Pathology, EarlyView.
The spatial distribution of perivascular proinflammation differs between PSP and CBD: PSP shows a predominance in basal ganglia (BG), whereas CBD demonstrates more widespread involvement of both BG and superior/middle frontal gyrus (S/M‐FG). PSP exhibits profound proinflammatory activation around venules while CBD affects a comparable magnitude around ...
Mu‐Hui Fu, Gokhan Uruk, Rodolfo G. Gatto, R. Ross Reichard, Jennifer L. Whitwell, Keith A. Josephs   +5 more
wiley   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

Nature Communications
Brain waste is cleared via a cerebrospinal fluid (CSF) pathway, the glymphatic system, whose dysfunction may underlie many brain conditions. Previous studies show coherent vascular oscillation, measured by blood oxygenation level-dependent (BOLD) fMRI ...
Kai-Hsiang Chuang, Xiaoqing Alice Zhou, Ying Xia, Zengmin Li, Lei Qian, Eamonn Eeles, Grace Ngiam, Jurgen Fripp, Elizabeth J. Coulson   +8 more
doaj   +1 more source

Hypercania’s Effect on Ocular Glymphatic Function

UF Journal of Undergraduate Research
The consequences of a hypercapnic environment underscore negative alterations in crucial physiological processes in the CNS. This project studied how elevated CO2 impacts the ocular glymphatic system by having participants breathe elevated CO2 and undergo delayed MRI following gadolinium contrast administration.
openaire   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Frontiers in Aging Neuroscience
While repetitive transcranial magnetic stimulation (rTMS) is a promising neuromodulatory intervention for cognitive impairment, its effects on the glymphatic system remain unexplored in clinical populations.
Mark H. Sundman, Yilin Liu, Nan-kuei Chen, Ying-hui Chou, Ying-hui Chou   +4 more
doaj   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

Air pollution, glymphatic impairment, and Alzheimer's disease

, 2023
Epidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD).
Uschi Graham, Alison Elder, Hussain, Rashad, Elder, Alison, Maiken Nedergaard, Graham, Uschi, Rashad Hussain, Nedergaard, Maiken   +7 more
core   +1 more source