Results 71 to 80 of about 6,124,437 (230)

In Vivo Dynamic D2O‐MRI for Quantifying Apparent CSF Water Renewal Across Ventricular and Extraventricular Compartments

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The choroid plexus has long been regarded as the principal source of cerebrospinal fluid (CSF), yet this view remains unresolved. We developed a dynamic indirect D2O MRI approach to quantify regional apparent CSF water renewal in vivo in rats at 9.4 T.
Zhao Zhang, Yun Wu, Yanmin Zheng, Zhuoyang Lin, Ye Li, Qiong Ye   +5 more
wiley   +1 more source

Potential value of slow‐wave sleep in management of chronic insomnia disorder

Sleep Research, EarlyView.
Abstract Chronic insomnia disorder (CID), acknowledged as the most common sleep disorder, has traditionally been diagnosed and managed with a focus on reducing sleep onset latency and extending total sleep duration. However, the critical importance of slow‐wave sleep (SWS), a key indicator of objective sleep quality, has been largely overlooked in ...
Liping Zhang, Qi Wu, Mengmeng Fan, Xianchao Zhao, Changjun Su   +4 more
wiley   +1 more source

Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

Frontiers in Aging Neuroscience, 2020
Objective: The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain.Methods: We recruited 213 healthy participants.
Wei Zhou, Bo Shen, Wei-qiang Shen, Hao Chen, Yi-feng Zheng, Jing-jing Fei   +5 more
doaj   +1 more source

Glymphatic MRI in idiopathic normal pressure hydrocephalus

, 2017
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer’s disease and brain ...
Eide, Per Kristian, Vatnehol, Svein Are Sirirud, Ringstad, Geir   +2 more
core   +1 more source

Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats [PDF]

, 2020
The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been linked to several neurological conditions, including traumatic brain injury (TBI).
Shultz, SR, Christensen, J, Wright, David K., Mychasiuk, Richelle, Yamakawa, GR, Christensen, Jennaya, Mychasiuk, R, Wright, DK, Yamakawa, Glenn R., Shultz, Sandy R.; id_orcid   +9 more
core   +1 more source

Alterations in brain physiological pulsations in Parkinson's disease: a case-control study

NeuroImage: Reports
Introduction: Brain physiological pulsations drive glymphatic clearance of neurotoxins from the brain. Neurodegenerative proteinopathies, including Parkinson's disease (PD), have altered glymphatic function.
Rodolphe Nenert, Corina Catiul, Pierre LeVan, Aya M. Miften, Jerzy P. Szaflarski, Amy W. Amara   +5 more
doaj   +1 more source

Quantitative Imaging of Water Diffusion in Brain Parenchyma at Cellular Resolution Using Stimulated Raman Scattering Microscopy

Small, EarlyView.
A multimodal multiphoton imaging framework enables high‐resolution quantification of water diffusion in brain tissue. By tracking deuterated water via stimulated Raman scattering (SRS) microscopy, this study resolves the microscopic heterogeneity of water diffusion at cellular resolution and determines apparent diffusion coefficients in health and ...
Wakana Ozaki, Ayano Suzuki, Satoshi Ii, Masato Yasui, Mutsuo Nuriya   +4 more
wiley   +1 more source

Glymphatic dysfunction mediates inflammation-driven vascular burden and cognitive decline in cerebral small vessel disease

Neurobiology of Disease
Background: Cerebral small vessel disease (CSVD) is increasingly recognized as a disorder involving microvascular dysfunction, impaired perivascular clearance, and inflammatory processes. However, how systemic inflammatory burden, neurovascular coupling (
Yilei Chen, Jiejing Zhang, Yingjie Kang, Mei Yang, Yingying Zhang, Xuying Zhu, Yanwen Huang, Yingnan Kong, Hui Wang, Songhua Zhan, Wenli Tan   +10 more
doaj   +1 more source

Association of enlarged perivascular space burden with silent cerebral infarcts in children with sickle cell disease

British Journal of Haematology, EarlyView.
Enlarged perivascular spaces (ePVS) in the basal ganglia and centrum semiovale are highly prevalent in children with sickle cell disease (SCD). Enlarged PVS in the basal ganglia are associated with the presence of silent cerebral infarcts, another marker of neurological disease, in children with SCD. Summary Children with sickle cell disease (SCD) have
Kristine A. Karkoska, Jahnavi Gollamudi, Brady J. Williamson, Russell P. Sawyer, Daniel Woo, Achala Vagal, Hyacinth I. Hyacinth   +6 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source