Results 191 to 200 of about 352,015 (307)

Correction: VZV IE4 downregulates cellular surface MHC-I via sequestering it to the golgi complex. [PDF]

Cell Mol Life Sci
Ye Y, Li S, Yan X, Zheng Q, Xue M, Wang H, Zheng C.   +6 more
europepmc   +1 more source

Putative role of TMEM165 in congenital cardiomyopathies. [PDF]

Front Mol Neurosci
Gonçalves PP.
europepmc   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Investigating and correcting a rare pathogenic mutation in GDF11. [PDF]

HGG Adv
Congdon ST, Bennett J, Opinya R, Agosto AR, Dossias O, Kokko C, Levesque AA, Koob AO, Silver AC, Thomas-Charles CA.   +9 more
europepmc   +1 more source

Climate factors drive the local adaptation of Old World cattle

iMeta, EarlyView.
Climate adaptation genomics of cattle. We comparatively analyzed genomic data from 85 Old World cattle breeds/populations of Eurasia and Africa to identify genetic factors associated with climate factors. Environmental genome‐wide association studies revealed 3165 single‐nucleotide polymorphisms (SNPs) with strong correlations between climate factors ...
Luyang Sun, Liangliang Jin, Ting Sun, Chenqi Bian, Fuwen Wang, Shuang Li, Hao Li, Jianyong Liu, Jicai Zhang, Johannes A. Lenstra, Artem Nedoluzhko, Zhuqing Zheng, Ruidong Xiang, Wai Yee Low, Wangdui Basang, Zhuzha Basang, Bin Li, Quji Suolang, Li Zhao, Wangmu Silang, Luobu Ciren, Zhandui Pubu, Qiangma Xire, Yanliang Song, Yuanpeng Gao, Dawei Wei, Rende Song, Min‐Sheng Peng, Bizhi Huang, Yun Ma, Xiaoting Xia, Chuzhao Lei, Ningbo Chen   +32 more
wiley   +1 more source

Functionally coupled ion channels begin co-assembling at the start of their synthesis. [PDF]

Elife
Pournejati R, Huang JM, Ma M, Moreno CM, Vivas O.   +4 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition. [PDF]

Diabetes
Blom SE, Narsian PR, Behan-Bush RM, Ankrum JA, Yang L, Stephens SB.   +5 more
europepmc   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source