Involvement of GTPases and vesicle adapter proteins in Heparan sulfate biosynthesis: role of Rab1A, Rab2A and GOLPH3. [PDF]
FEBS JVesicle trafficking governs the biosynthesis of heparan sulfate (HS) by controlling the positioning of HS‐modifying enzymes within Golgi compartments. The proteins Rab1A and Rab2A play dynamic, compensatory roles that affect HS levels by influencing the transport of these enzymes.
Meneghetti MCZ +4 more
europepmc +3 more sources
GOLPH3-mTOR Crosstalk and Glycosylation: A Molecular Driver of Cancer Progression [PDF]
CellsOriginally identified in proteomic-based studies of the Golgi, Golgi phosphoprotein 3 (GOLPH3) is a highly conserved protein from yeast to humans. GOLPH3 localizes to the Golgi through the interaction with phosphatidylinositol-4-phosphate and is required
Anna Frappaolo +2 more
doaj +3 more sources
GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway [PDF]
Frontiers in GeneticsBackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie +5 more
doaj +3 more sources
GOLPH3 promotes calcium oxalate-induced renal injury and fibrosis through Golgi stress-mediated apoptosis and inflammatory responses [PDF]
Scientific ReportsA common urological disorder, calcium oxalate (CaOx) stones are the most common form of kidney stones. Deposition of CaOx crystals leads to tubular damage, interstitial fibrosis, and chronic kidney disease.
Bao-feng Song +6 more
doaj +4 more sources
Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis [PDF]
Frontiers in PharmacologyBackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an ...
Lihua Chen +11 more
doaj +4 more sources
Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex [PDF]
Stem Cell Research & TherapyBackground Lung cancer is a common malignant neoplasm, one of the leading causes of death worldwide. Cancer stem cells (CSCs) drive tumor recurrence, progression, and therapeutic resistance.
Feng Zhang +10 more
doaj +3 more sources
Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression [PDF]
Integrative Cancer Therapies, 2020 Protosappanin B (PSB) is a key active component of Lignum Sappan extract. Although the antiproliferative effects of Lignum Sappan extract have been demonstrated in various cancer cells, relatively little is known about the effects of PSB on tumor ...
Xue-Cong Zheng +7 more
doaj +2 more sources
GOLPH3 Promotes Cancer Growth by Interacting With STIP1 and Regulating Telomerase Activity in Pancreatic Ductal Adenocarcinoma [PDF]
Frontiers in Oncology, 2020 Overexpression of Golgi phosphoprotein 3 (GOLPH3) predicts poor prognosis and is a potential therapeutic target in pancreatic ductal adenocarcinoma (PDAC).
Kebing Wang +10 more
doaj +2 more sources
GOLPH3 modulates expression and alternative splicing of transcription factors associated with endometrial decidualization in human endometrial stromal cells [PDF]
PeerJ, 2023 Endometrial decidualization is a decidual tissue formed by the proliferation and re-differentiation of endometrial stroma stimulated by decidualization inducing factors. It is very important for the proper maintenance of pregnancy.
Suqin Zhu +7 more
doaj +3 more sources
Comparative analysis of GOLPH3 expression in lymph node-positive prostate cancer: immunohistochemistry staining patterns and clinical significance [PDF]
Frontiers in Oncology, 2023 IntroductionProstate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Lymph node metastasis is a poor prognostic factor for PCa.
Paweł Kiełb +11 more
doaj +2 more sources