Results 91 to 100 of about 1,450 (167)
Phosphoinositide Metabolism: Biochemistry, Physiology and Genetic Disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Phosphatidylinositol, a glycerophospholipid with a myo‐inositol head group, can form seven different phosphoinositides (PItds) by phosphorylation at inositol carbons 3, 4 and/or 5. Over 50 kinases and phosphatases participate in PItd metabolism, creating an interconnected PItd network that allows for precise temporal and spatial regulation of ...
Francis Rossignol +2 more
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Lentivirus Mediated GOLPH3 shRNA Inhibits Growth and Metastasis of Esophageal Squamous Cancer
Asian Pacific Journal of Cancer Prevention, 2013 To investigate the role of Golgi phosphoprotein 3 (GOLPH3) in tumour growth and metastasis of esophageal squamous cancer.A lentiviral shRNA-vector was utilized to stably knockdown GOLPH3 in Eca-109 esophageal squamous cancer cells. mRNA transcription and protein expression of GOLPH3 were examined by real-time quantitative PCR and Western blotting ...
Qiang, Wang, Xian, Wang, Can-Bin, Zhang
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Zhongguo shiyan zhenduanxue, 2022 目的 探讨高尔基体磷酸化蛋白3（GOLPH3）、血管内皮生长因子（VEGF）在胃癌组织中的表达情况及其临床意义。方法 选取2018年2月—2019年3月于河北北方学院附属第一医院行胃癌根治性切除手术的103例患者作为研究对象，分析所选患者的临床资料，收集其胃癌组织及癌旁组织。比较不同TNM分期、浸润深度、分化程度、淋巴结转移胃癌患者GOLPH3、VEGF表达情况。结果胃癌组织GOLPH3、VEGF阳性表达率分别为66.02%、58.25%，均高于癌旁组织的19.42%、23.30%（P＜0.05 ...
王锐 +6 more
doaj
High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma
Molecular Medicine Reports, 2015 Golgi phosphoprotein 3 (GOLPH3) overexpression has previously been associated with the progression of several solid tumors, which resulted in adverse clinical outcomes. The present study aimed to determine the expression and prognostic significance of GOLPH3 in human hepatocellular carcinoma (HCC).
Qian, Li, Yuwen, Ma, Wanpeng, Xu
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Journal of Experimental & Clinical Cancer Research, 2018 Background Serine/threonine protein kinase 25 (STK25) is critical in regulating whole-body glucose and insulin homeostasis and the accumulation of ectopic lipids.
Fan Wu +7 more
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Effect of LINC00657 on Apoptosis of Breast Cancer Cells by Regulating miR-590-3p
Cancer Management and Research, 2020 Qiuli Shan,1 Fan Qu,1 Weiping Yang,2 Ningning Chen1 1College of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China; 2Department of Thyroid Breast Surgery, Qingdao Chengyang People’s Hospital ...
Shan Q, Qu F, Yang W, Chen N
doaj
GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy.
American journal of cancer researchDue to the hypoxia and nutrient deficiency microenvironment, malignant glioma exhibits high autophagy activity and autophagy plays a significant role in the occurrence and development of glioma. However, the potential molecular mechanism of autophagy in glioma remains unknown. In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3),
Kai, Wang +9 more
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miR-186 inhibits cell proliferation of prostate cancer by targeting GOLPH3.
American journal of cancer research, 2016 Prostate cancer is one of the leading causes of cancer deaths among men, many miRNAs have been demonstrated to play critical role in the progression of prostate cancer, miR-186 suppresses the progression of many tumors, such as bladder cancer and glioma.
Xing, Hua +7 more
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