Results 91 to 100 of about 2,350 (202)

The close relationship between the Golgi trafficking machinery and protein glycosylation [PDF]

, 2020
La glicosilazione è la più comune modifica post-traduzionale delle proteine; media la loro corretta piegatura e stabilità, nonché il loro trasporto attraverso il trasporto secretorio.
Frappaolo A., Giansanti M. G., Karimpour Ghahnavieh A., Sechi S.   +3 more
core   +1 more source

Molecular hydrogen protects against sepsis‐induced cardiomyopathy through improving Golgi stress‐mediated autophagy, inflammation and apoptosis

British Journal of Pharmacology, Volume 182, Issue 22, Page 5627-5646, November 2025.
Background and Purpose Sepsis‐induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular ...
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, Shuaijie Pei, Xiaofan Huang, Lina Zhao, Keliang Xie   +9 more
wiley   +1 more source

GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer

Journal of Translational Medicine, 2012
Background Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome.
Li Huan, Guo Ling, Chen Shu-Wei, Zhao Xiao-Hui, Zhuang Shi-Min, Wang Li-Ping, Song Li-Bing, Song Ming   +7 more
doaj   +1 more source

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma [PDF]

, 2016
Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in ...
Huhtala, Heini, Laranne, Jussi, Lemstrom, Karl, Paavonen, Timo, Pohjola, Konsta, Rautiainen, Markus, Renkonen, Risto, Seppälä, Miia, Toppila-Salmi, Sanna   +8 more
core   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes [PDF]

, 2017
Congenital disorders of glycosylation (CDG) comprise a family of human multisystemic diseases caused by recessive mutations in genes required for protein N-glycosylation.
Belloni, G., Frappaolo, A., Fraschini, R., Giansanti, M. G., Karimpour-Ghahnavieh, A., Kumagai, T., Piergentili, R., Robinson, S., Sechi, S., Tiemeyer, K. H., Tiemeyer, M.   +10 more
core   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, Volume 47, Issue 10, October 2025.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer

Tumor Biology, 2012
This study aims to investigate the expression and significance of GOLPH3 in human gastric cancer progression and prognosis. Using immunohistochemistry (IHC) and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of GOLPH3 in gastric cancer tissues compared to paired normal stomach mucosa ...
Ben-Shun, Hu, Hao, Hu, Cong-Yuan, Zhu, Yuan-Long, Gu, Jian-Ping, Li   +4 more
openaire   +2 more sources

Investigating the trafficking of Golgi-resident glycosylation enzymes [PDF]

, 2019
The Golgi is a major site of glycan processing mediated by a large number of Golgi-resident glycosylation enzymes. These enzymes are largely type II transmembrane domain (TMD) proteins consisting of a short N-terminal cytosolic tail, a short TMD and a ...
Welch, Lawrence George
core   +1 more source

Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond

Macromolecular Bioscience, Volume 25, Issue 8, August 2025.
Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley   +1 more source