Results 131 to 140 of about 1,450 (167)

GOLPH3 inhibits erastin‐induced ferroptosis in colorectal cancer cells

Cell Biology International
Ferroptosis is a novel form of programmed cell death and is considered to be a druggable target for colorectal cancer (CRC) therapy. However, the role of ferroptosis in CRC and its underlying mechanism are not fully understood.
Lihua Chen   +6 more
semanticscholar   +3 more sources

CENPK Orchestrates Ovarian Cancer Progression via GOLPH3-Mediated Activation of mTOR Signaling.

Molecular and Cellular Endocrinology
Ovarian cancer stands as a formidable clinical challenge, with limited therapeutic options. This investigation delves into the intricate molecular mechanisms governing ovarian cancer progression and uncovers Centromere Protein K (CENPK) as a central ...
Gaolian Li   +14 more
semanticscholar   +3 more sources

GOLPH3 Promotes Vascular Mimicry via the Epithelial Mesenchymal Transition in Glioblastoma Cells.

Turkish Neurosurgery, 2022
AIM As an oncogene, Golgi phosphoprotein 3 (GOLPH3) gene promotes migration and invasion in glioma cells. RESULTS Vasculogenic mimicry (VM) formation implies exacerbation in glioma patients.
Jun Jia   +7 more
semanticscholar   +3 more sources

Molecular Regulation and Physiological Role of GOLPH3-mediated Golgi retention

open access: yesbioRxiv
AbstractThe Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins traverse this organelle has long been debated. Recent studies have identified a molecular machinery that sorts resident proteins into retrograde-directed COPI vesicles during ...
Anastasia Theodoropoulou   +26 more
semanticscholar   +2 more sources

GOLPH3 Regulates Exosome miRNA Secretion in Glioma Cells

Journal of Molecular Neuroscience, 2020
We aimed to examine whether golgi protein GOLPH3 could affect the secretion of glioma cell-derived exosomes. The exosomes were extracted by ultra-centrifugation from the supernatant of U251 and U87 cell cultures and identified by transmission electron microscopy (TEM), Malvern analyzer, and western blot.
Pengfei Hu   +9 more
openaire   +2 more sources

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