Results 31 to 40 of about 1,450 (167)

ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer [PDF]

BMC Cancer, 2018
Background Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer.
Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei   +8 more
doaj   +3 more sources

FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer [PDF]

Frontiers in Oncology, 2019
Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS.
Li-Na Yu, Li-Na Yu, Li-Na Yu, Zhen Liu, Yan Tian, Yan Tian, Yan Tian, Pei-Pei Zhao, Pei-Pei Zhao, Pei-Pei Zhao, Xing Hua   +10 more
doaj   +3 more sources

In silico identification of alkaloids and repurposed drugs as potential small-molecule inhibitors of GOLPH3 in cancer using molecular docking, molecular dynamics, and MM-PBSA analysis

Discover Chemistry
GOLPH3 is a PI(4)P-binding oncoprotein implicated in tumor progression, metastasis, and drug resistance, yet no direct small-molecule inhibitors of this target have been reported.
Zechariah Oluwapelumi Oresanya, Godswill Chimezirim Eleanya, Taiwo Abdulmaruf Akande, Titilayo Mary Jesugbemi, Rahmon Kanmodi   +4 more
doaj   +2 more sources

Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundGolgi phosphoprotein 3 (GOLPH3) is an oncoprotein localized in the Golgi apparatus. Abnormal GOLPH3 expression is potentially related to carcinogenesis. However, the potential biological regulation network of GOLPH3 in lung adenocarcinoma (LUAD)
Tong Zhang, Yue Wang, Yangyang Chen, Shuo Jin, Ying Gao, Dan Zhang, Yonghui Wu   +6 more
doaj   +1 more source

GOLPH3 keeps the Golgi residents at home [PDF]

Journal of Cell Biology, 2021
In this issue of JCB, Welch et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles. This explains how many resident proteins are retained at the Golgi and reveals a key role for GOLPH3 in maintaining Golgi homeostasis.
openaire   +3 more sources

Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. [PDF]

PLoS ONE, 2016
Golgi phosphoprotein 3 (GOLPH3) has been implicated in the development of carcinomas in many human tissues, and is currently considered a bona fide oncoprotein.
María J Tenorio, Breyan H Ross, Charlotte Luchsinger, Andrés Rivera-Dictter, Cecilia Arriagada, Diego Acuña, Marcelo Aguilar, Viviana Cavieres, Patricia V Burgos, Pamela Ehrenfeld, Gonzalo A Mardones   +10 more
doaj   +1 more source

Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways

Frontiers in Molecular Biosciences, 2022
Background: Golgi phosphoprotein 3 (GOLPH3) overexpression was recently reported to be associated with a poor clinical outcome in patients with colorectal cancer (CRC).
Anpei Huang, Ruizhi Wang, Ji Cui, Ying Gao, Zheng Yin, Lianzhou Chen, Meifang He, Wen Li   +7 more
doaj   +1 more source

Golgi phosphoprotein 3 induces autophagy and epithelial–mesenchymal transition to promote metastasis in colon cancer

Cell Death Discovery, 2022
In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT).
Li-Yun Gong, Ting Tu, Jing Zhu, Ao-Ping Hu, Jun-Wei Song, Jing-Qiang Huang, Yi Yang, Zeyao Zhu, Yu Chen   +8 more
doaj   +1 more source

GOLPH3 Links the Golgi, DNA Damage, and Cancer [PDF]

Cancer Research, 2015
Abstract GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3′s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer.
Matthew D, Buschman, Juliati, Rahajeng, Seth J, Field   +2 more
openaire   +2 more sources

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer [PDF]

Nature, 2009
Genome-wide copy number analyses of human cancers identified a frequent 5p13 amplification in several solid tumour types, including lung (56%), ovarian (38%), breast (32%), prostate (37%) and melanoma (32%). Here, using integrative analysis of a genomic profile of the region, we identify a Golgi protein, GOLPH3, as a candidate targeted for ...
Scott, Kenneth L., Kabbarah, Omar, Liang, Mei-Chih, Ivanova, Elena, Anagnostou, Valsamo, Wu, Joyce, Dhakal, Sabin, Wu, Min, Chen, Shujuan, Feinberg, Tamar, Huang, Joseph, Saci, Abdel, Widlund, Hans R., Fisher, David E., Xiao, Yonghong, Rimm, David L., Protopopov, Alexei, Wong, Kwok-Kin, Chin, Lynda   +18 more
openaire   +2 more sources