Results 31 to 40 of about 1,218 (144)

Golgi Phosphoprotein 3 Mediates Radiation-Induced Bystander Effect via ERK/EGR1/TNF-α Signal Axis

Antioxidants, 2022
The radiation-induced bystander effect (RIBE), an important non-targeted effect of radiation, has been proposed to be associated with irradiation-caused secondary cancers and reproductive damage beyond the irradiation-treated area after radiotherapy ...
Feng Qin, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang, Wei Cao, Peizhong Kong, Shengjie Peng, Mingyu Sun, Lili Nie, Wei Han   +9 more
doaj   +1 more source

Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders

Cells, 2021
Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein localized to the Golgi apparatus and the cytosol. GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate [PI(4)P] and regulates Golgi architecture ...
Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D’Avino, Maria Grazia Giansanti   +7 more
doaj   +1 more source

Linking GOLPH3 and Extracellular Vesicles Content—a Potential New Route in Cancer Physiopathology and a Promising Therapeutic Target is in Sight?

Technology in Cancer Research & Treatment, 2022
Golgi phosphoprotein 3 (GOLPH3), a highly conserved phosphatidylinositol 4-phosphate effector, is required for maintenance of Golgi architecture, vesicle trafficking, and Golgi glycosylation. GOLPH3 overexpression has been reported in several human solid
Maria Grazia Giansanti PhD, Roberto Piergentili PhD   +1 more
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GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9

Cellular Physiology and Biochemistry, 2015
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) is a newly reported oncogene that plays a significant role in regulating cell growth. Recent research has shown that overexpression of GOLPH3 is correlated with patient survival and M classification in ...
Ran Wang, Zun-fu Ke, Fen Wang, Wen-hui Zhang, Yue-feng Wang, Shu-hua Li, Lian-tang Wang   +6 more
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High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma

Cancer Medicine, 2020
According to our previous study, GOLPH3 is markedly up‐expressed in tongue squamous cell carcinoma (TSCC), which is also associated with poor survival. However, it remains unclear about key upstream and downstream mechanisms of GOLPH3.
Shuwei Chen, Huan Li, Xiyuan Li, Wenkuan Chen, Xing Zhang, Zhongyuan Yang, Zhipeng Chen, Jingtao Chen, Ying Zhang, Dingbo Shi, Ming Song   +10 more
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The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner.

PLoS ONE, 2019
Golgi phosphoprotein 3 (GOLPH3) is a conserved protein of the Golgi apparatus that in humans has been implicated in tumorigenesis. However, the precise function of GOLPH3 in malignant transformation is still unknown.
Cecilia Arriagada, Charlotte Luchsinger, Alexis E González, Tomás Schwenke, Gloria Arriagada, Hugo Folch, Pamela Ehrenfeld, Patricia V Burgos, Gonzalo A Mardones   +8 more
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Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B.

PLoS ONE, 2020
Golgi phosphoprotein 3 (GOLPH3) is a peripheral membrane protein localized at the trans-Golgi network that is also distributed in a large cytosolic pool.
Viviana A Cavieres, Cristóbal Cerda-Troncoso, Andrés Rivera-Dictter, Rodrigo I Castro, Charlotte Luchsinger, Natacha Santibañez, Patricia V Burgos, Gonzalo A Mardones   +7 more
doaj   +1 more source

Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood.
Dong Lu, Hao Zhang, Jiale Fu, Yanhua Qi, Xu Wang, Shishuang Wu, Xiuping Zhou, Rutong Yu   +7 more
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The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage

Frontiers in Neuroscience, 2015
The Golgi protein GOLPH3 binds to PtdIns(4)P and MYO18A, linking the Golgi to the actin cytoskeleton. The GOLPH3 pathway is essential for vesicular trafficking from the Golgi to the plasma membrane.
Matthew D. Buschman, Mengke eXing, Seth J Field   +2 more
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Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

Scientific Reports, 2021
Golgi phosphoprotein 3 (GOLPH3) was the first reported oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells.
Juan C. Opazo, Michael W. Vandewege, Javier Gutierrez, Kattina Zavala, Luis Vargas-Chacoff, Francisco J. Morera, Gonzalo A. Mardones   +6 more
doaj   +1 more source