Results 71 to 80 of about 1,450 (167)

MiR-3150b-3p Inhibits the Progression of Colorectal Cancer Cells via Targeting GOLPH3 [PDF]

Journal of Investigative Medicine, 2020
The aim of this study was to investigate the function of miR-3150b-3p in malignant behaviors of colorectal cancer (CRC). The tumor-inhibitive effect of miR-3150b-3p was determined by cell viability, invasion, and migration assays. The influence of miR-3150b-3p on the expression of Golgi phosphoprotein 3 (GOLPH3) and Janus kinase 2 (JAK2)/signal ...
Zhang, Weiqing, Chen, Xiaoyan, Jia, Junzhi   +2 more
openaire   +2 more sources

Circular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma

Bioengineered, 2022
Circular RNAs, which are a novel subclass of noncoding RNAs, are reported to be involved in various biological processes. Aberrant expression of circular RNAs may promote cancer progression.
Chen Zou, Xia Li, Haigang Wei, Siyuan Wu, Jing Song, Zhe Tang, Hailing Luo, Xiaozhi Lv, Yilong Ai   +8 more
semanticscholar   +1 more source

Practical Outcomes From CASP16 for Users in Need of Biomolecular Structure Prediction

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 435-446, January 2026.
ABSTRACT The 16th Critical Assessment of Structure Prediction benchmarked advancements in biomolecular modeling, particularly in the context of AlphaFold 2 and 3 systems. Protein monomer and domain prediction is largely solved, with barely any space for further improvements at the backbone level except for very specific details, irregular secondary ...
Luciano A. Abriata, Matteo Dal Peraro
wiley   +1 more source

Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression

Integrative Cancer Therapies, 2020
Protosappanin B (PSB) is a key active component of Lignum Sappan extract. Although the antiproliferative effects of Lignum Sappan extract have been demonstrated in various cancer cells, relatively little is known about the effects of PSB on tumor ...
Xue-Cong Zheng, Ze-Sheng Shi, Cheng-Zhi Qiu, Zhong-Shi Hong, Chun-Xiao Wang, Hai-Bin Zhuang, Zhi-Chuan Chen, Jian-Peng Pan   +7 more
doaj   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer

Diagnostic Pathology, 2012
Background To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value. Methods Immunohistochemical staining for GOLPH3 was performed on tissue microarrays of 342 prostate patients.
Hua Xing, Yu Lina, Pan Wenhai, Huang Xiaoxiao, Liao Zexiao, Xian Qi, Fang Li, Shen Hong   +7 more
doaj   +1 more source

GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer

Journal of Translational Medicine, 2012
Background Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome.
Li Huan, Guo Ling, Chen Shu-Wei, Zhao Xiao-Hui, Zhuang Shi-Min, Wang Li-Ping, Song Li-Bing, Song Ming   +7 more
doaj   +1 more source

Molecular hydrogen protects against sepsis‐induced cardiomyopathy through improving Golgi stress‐mediated autophagy, inflammation and apoptosis

British Journal of Pharmacology, Volume 182, Issue 22, Page 5627-5646, November 2025.
Background and Purpose Sepsis‐induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular ...
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, Shuaijie Pei, Xiaofan Huang, Lina Zhao, Keliang Xie   +9 more
wiley   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer

Tumor Biology, 2012
This study aims to investigate the expression and significance of GOLPH3 in human gastric cancer progression and prognosis. Using immunohistochemistry (IHC) and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of GOLPH3 in gastric cancer tissues compared to paired normal stomach mucosa ...
Ben-Shun, Hu, Hao, Hu, Cong-Yuan, Zhu, Yuan-Long, Gu, Jian-Ping, Li   +4 more
openaire   +2 more sources