Results 81 to 90 of about 2,350 (202)

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

miR-126 targeting GOLPH3 inhibits the epithelial-mesenchymal transition of gastric cancer BGC-823 cells and reduces cell invasion

European Journal of Histochemistry, 2020
The incidence and mortality of gastric cancer have been increasing in recent years. MiR-126 and target genes have been studied in gastric cancer, but their studies with Golgi phosphoprotein 3 (GOLPH3) and related pathways in gastric cancer are rarely ...
Jiancai Ouyang, Fuhu Song, He Li, Rui Yang, Haicheng Huang   +4 more
doaj   +1 more source

Practical Outcomes From CASP16 for Users in Need of Biomolecular Structure Prediction

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 435-446, January 2026.
ABSTRACT The 16th Critical Assessment of Structure Prediction benchmarked advancements in biomolecular modeling, particularly in the context of AlphaFold 2 and 3 systems. Protein monomer and domain prediction is largely solved, with barely any space for further improvements at the backbone level except for very specific details, irregular secondary ...
Luciano A. Abriata, Matteo Dal Peraro
wiley   +1 more source

MiR-3150b-3p Inhibits the Progression of Colorectal Cancer Cells via Targeting GOLPH3 [PDF]

Journal of Investigative Medicine, 2020
The aim of this study was to investigate the function of miR-3150b-3p in malignant behaviors of colorectal cancer (CRC). The tumor-inhibitive effect of miR-3150b-3p was determined by cell viability, invasion, and migration assays. The influence of miR-3150b-3p on the expression of Golgi phosphoprotein 3 (GOLPH3) and Janus kinase 2 (JAK2)/signal ...
Zhang, Weiqing, Chen, Xiaoyan, Jia, Junzhi   +2 more
openaire   +2 more sources

Metformin antagonizes nickel-refining fumes-induced cell pyroptosis via Nrf2/GOLPH3 pathway in vitro and in vivo

Ecotoxicology and Environmental Safety, 2022
Nickel compounds, an international carcinogen in the industrial environment, increased the risk of lung inflammation even lung cancer in Ni refinery workers.
Tong Zhang, Yue Wang, Wenxue Yao, Yangyang Chen, Dan Zhang, Ying Gao, Shuo Jin, Lina Li, Shikuan Yang, Yonghui Wu   +9 more
doaj   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer

Diagnostic Pathology, 2012
Background To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value. Methods Immunohistochemical staining for GOLPH3 was performed on tissue microarrays of 342 prostate patients.
Hua Xing, Yu Lina, Pan Wenhai, Huang Xiaoxiao, Liao Zexiao, Xian Qi, Fang Li, Shen Hong   +7 more
doaj   +1 more source

Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression

Integrative Cancer Therapies, 2020
Protosappanin B (PSB) is a key active component of Lignum Sappan extract. Although the antiproliferative effects of Lignum Sappan extract have been demonstrated in various cancer cells, relatively little is known about the effects of PSB on tumor ...
Xue-Cong Zheng, Ze-Sheng Shi, Cheng-Zhi Qiu, Zhong-Shi Hong, Chun-Xiao Wang, Hai-Bin Zhuang, Zhi-Chuan Chen, Jian-Peng Pan   +7 more
doaj   +1 more source

Granulosa cell apoptosis in the ovarian follicle - a changing view [PDF]

, 2018
Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte.
Arun Dharmarajan, Frank Arfuso, John L. Yovich, John L. Yovich, Phil G. Knight, Sheena L. P. Regan, Yee Leung   +6 more
core   +3 more sources