Results 11 to 20 of about 1,206 (166)

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways [PDF]

International Journal of Molecular Sciences, 2019
Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB and NLRP3 signaling pathways, lie at the core of gout. This study aimed to evaluate the antigout effect of Cichorium intybus L. (also known as chicory) in vivo and in vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections.
Yu Wang, Zhijian Lin, Bing Zhang, Zhuoxi Jiang, Fanfan Guo, Ting Yang   +5 more
openaire   +2 more sources

Effect of renal impairment on the pharmacokinetics and safety of dorzagliatin, a novel dual‐acting glucokinase activator

Clinical and Translational Science, Volume 15, Issue 2, Page 548-557, February 2022., 2022
Abstract Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI) on dorzagliatin’s pharmacokinetics (PKs) and safety, and to guide appropriate clinical ...
Jia Miao, Ping Fu, Shuang Ren, Chao Hu, Ying Wang, Chengfeng Jiao, Ping Li, Yu zhao, Cui Tang, Yuli Qian, Rong Yang, Yanli Dong, Jing Rong, Yaohui Wang, Xiaowei Jin, Yu Sun, Li Chen   +16 more
wiley   +1 more source

Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID‐19

International Journal of Biomaterials, Volume 2022, Issue 1, 2022., 2022
The COVID‐19 pandemic has once again prompted people to resort to the remedies of folk and alternative medicine. Medicinal plants, because of their chemical composition, pharmacological properties, and the action of biologically active substances, can stop and relieve the symptoms of the disease.
Viktor Kamkin, Aidana Kamarova, Baurzhan Shalabayev, Assyltas Kussainov, Marat Anuarbekov, Serik Abeuov, Sameh Ali   +6 more
wiley   +1 more source

Self‐reported medication intake vs information from other data sources such as pharmacy records or medical records: Identification and description of existing publications, and comparison of agreement results for publications focusing on patients with cancer ‐ a systematic review

Pharmacoepidemiology and Drug Safety, Volume 30, Issue 5, Page 531-560, May 2021., 2021
Abstract Purpose To identify and describe publications addressing the agreement between self‐reported medication and other data sources among adults and, in a subgroup of studies dealing with cancer patients, seek to identify parameters which are associated with agreement. Methods A systematic review including a systematic search within five biomedical
Manuela Brüne, Carina Emmel, Gisela Meilands, Silke Andrich, Sigrid Droste, Heiner Claessen, Fabian Jülich, Andrea Icks   +7 more
wiley   +1 more source

Direct healthcare professional communications: A quantitative assessment study

Pharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Abstract A retrospective observational study evaluated the direct healthcare professional communication (DHPC) letters disseminated by the Saudi Food and Drug Authority (SFDA) and their compliance with the pharmacovigilance guidelines. The study was utilized all DHPC letters available on the SFDA website, which is intended to communicate drug safety ...
Hajar Alsaleh, Thamir M. Alshammari
wiley   +1 more source

Combinatory Effects of Bone Marrow‐Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant‐Induced Arthritis in Wistar Rats: Roles of IL‐1β, IL‐4, Nrf‐2, and Oxidative Stress

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Rheumatoid arthritis (RA) is a disorder triggered by autoimmune reactions and related with chronic inflammation and severe disability. Bone Marrow‐derived Mesenchymal Stem Cells (BM‐MSCs) have shown a hopeful immunomodulatory effect towards repairing cartilage and restoring joint function.
Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Emad A. Mahdi, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour, Arham Shabbir   +7 more
wiley   +1 more source

Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer:a population-based case-control study [PDF]

, 2019
Background: Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk.Methods ...
Adolfsson, Jan, Beckmann, Kerri, Garmo, Hans, Holmberg, Lars, Häggström, Christel, Josephs, Debra, Russell, Beth, Stattin, Pär, Van Hemelrijck, Mieke   +8 more
core   +4 more sources

Uso de corticoides sistémicos no tratamento da artrite gotosa aguda: qual a evidência?

Revista Portuguesa de Medicina Geral e Familiar, 2019
Objetivo: Avaliar a eficácia dos corticóides sistémicos (CS) no tratamento da artrite gotosa aguda (AGA) e os seus benefícios face às terapêuticas clássicas nomeadamente a colchicina e os anti-inflamatórios não esteroides (AINEs).
Ana Margarida Costa, Ana Isabel Ribeiro da Silva   +1 more
doaj   +1 more source

The multidrug transporter ABCG2: still more questions than answers [PDF]

, 2016
ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules.
Aaron J. Horsey, Agarwal, Allen, Allikmets, Aronica, Bai, Bartholomae, Basseville, Bauer, Benderra, Clark, Damiani, Damiani, Darby, Dezi, Doyle, Egido, Ejendal, Faneyte, Gozzi, Gutmann, Haider, Haider, Hang, Henriksen, Hirschmann-Jax, Ian D. Kerr, Jonker, Jonker, Kage, Kerr, Kerr, Keskitalo, Kim, Kourti, Kruijtzer, Li, Maliepaard, Mao, Mao, McDevitt, McDevitt, Megan H. Cox, Miyake, Mo, Nakagawa, Ni, Ni, Ota, Robey, Rosenberg, Rosenberg, Sauerbrey, Sissung, Sunehera Sarwat, Suvannasankha, Tian, Tsunoda, van den Heuvel-Eibrink, van Herwaarden, Wang, Wong, Wong, Woodward, Xiang, Xu, Xu, Yoh, Yoshikawa, Zhang   +69 more
core   +2 more sources

Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

Arthritis Research & Therapy, 2022
Abstract Objective Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering therapy (ULT) titration to target, we performed a prospective study of ...
Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan, Robert Terkeltaub   +11 more
openaire   +7 more sources