Results 11 to 20 of about 1,194 (166)
Do proton pump inhibitors increase the risk of dementia? A systematic review, meta‐analysis and bias analysis [PDF]
British Journal of Clinical Pharmacology, Volume 89, Issue 2, Page 602-616, February 2023., 2022 AimPrevious studies on the association between proton pump inhibitor (PPI) intake and the increased risk of dementia has shown discrepancies in their conclusions.
Ahn, Nayeon +10 more
core +3 more sources
Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage [PDF]
Molecules, 2021 Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues. The etiology of gout is directly linked to the NLRP3 inflammasome, since MSU crystals are NLRP3 inflammasome activators. Therefore, we decided to search for a small-molecule inhibitor of the NLRP3 inflammasome for the prevention of gout ...
Nuri Choi +6 more
openaire +3 more sources
A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression [PDF]
Frontiers in Pharmacology, 2021 Background: Activation of nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in gout. Selaginella moellendorffii has been confirmed effective for the treatment of gout in hospital preparations. Flavonoids, such as amentoflavone (AM), are the main active components of this medicine.Purpose: We aimed to ...
Xueyan Zhang +7 more
openaire +3 more sources
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression [PDF]
Journal of Neuroinflammation, 2017 Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-
Hai-Jiao Liu +9 more
openaire +3 more sources
Prediction of renal and cardiometabolic outcomes in gout during urate‐lowering therapy by sonography
International Journal of Rheumatic Diseases, Volume 26, Issue 12, Page 2450-2459, December 2023., 2023 Abstract Objectives To assess whether the extent of monosodium urate (MSU) crystal deposition estimated by ultrasound could predict renal and cardiometabolic events during urate‐lowering therapy (ULT). Methods A prospective study on gout patients from two referral centers initiating ULT who underwent baseline ultrasound and were followed for 1 year ...
Irene Calabuig +7 more
wiley +1 more source
Prescribing cascades in community‐dwelling adults: A systematic review
Pharmacology Research &Perspectives, Volume 10, Issue 5, October 2022., 2022 Prescribing cascades in community dwelling adults: Systematic review. Abstract The misattribution of an adverse drug reaction (ADR) as a symptom or illness can lead to the prescribing of additional medication, referred to as a prescribing cascade. The aim of this systematic review is to identify published prescribing cascades in community‐dwelling ...
Ann S. Doherty +8 more
wiley +1 more source
Cell Biology International, Volume 46, Issue 9, Page 1320-1344, September 2022., 2022 Abstract Immune‐mediated diseases (IMDs) are chronic conditions that have an immune‐mediated etiology. Clinically, these diseases appear to be unrelated, but pathogenic pathways have been shown to connect them. While inflammation is a common occurrence in the body, it may either stimulate a favorable immune response to protect against harmful signals ...
Saman Sargazi +8 more
wiley +1 more source
Clinical and Translational Science, Volume 15, Issue 2, Page 548-557, February 2022., 2022 Abstract Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI) on dorzagliatin’s pharmacokinetics (PKs) and safety, and to guide appropriate clinical ...
Jia Miao +16 more
wiley +1 more source
Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis [PDF]
Molecules, 2019 Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the gout inflammatory symptoms induced by MSU crystals.
Hye Eun Lee +6 more
openaire +3 more sources
International Journal of Biomaterials, Volume 2022, Issue 1, 2022., 2022 The COVID‐19 pandemic has once again prompted people to resort to the remedies of folk and alternative medicine. Medicinal plants, because of their chemical composition, pharmacological properties, and the action of biologically active substances, can stop and relieve the symptoms of the disease.
Viktor Kamkin +6 more
wiley +1 more source