Results 21 to 30 of about 1,194 (166)

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways [PDF]

International Journal of Molecular Sciences, 2019
Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB and NLRP3 signaling pathways, lie at the core of gout. This study aimed to evaluate the antigout effect of Cichorium intybus L. (also known as chicory) in vivo and in vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections.
Yu Wang, Zhijian Lin, Bing Zhang, Zhuoxi Jiang, Fanfan Guo, Ting Yang   +5 more
openaire   +2 more sources

Self‐reported medication intake vs information from other data sources such as pharmacy records or medical records: Identification and description of existing publications, and comparison of agreement results for publications focusing on patients with cancer ‐ a systematic review

Pharmacoepidemiology and Drug Safety, Volume 30, Issue 5, Page 531-560, May 2021., 2021
Abstract Purpose To identify and describe publications addressing the agreement between self‐reported medication and other data sources among adults and, in a subgroup of studies dealing with cancer patients, seek to identify parameters which are associated with agreement. Methods A systematic review including a systematic search within five biomedical
Manuela Brüne, Carina Emmel, Gisela Meilands, Silke Andrich, Sigrid Droste, Heiner Claessen, Fabian Jülich, Andrea Icks   +7 more
wiley   +1 more source

Direct healthcare professional communications: A quantitative assessment study

Pharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Abstract A retrospective observational study evaluated the direct healthcare professional communication (DHPC) letters disseminated by the Saudi Food and Drug Authority (SFDA) and their compliance with the pharmacovigilance guidelines. The study was utilized all DHPC letters available on the SFDA website, which is intended to communicate drug safety ...
Hajar Alsaleh, Thamir M. Alshammari
wiley   +1 more source

Combinatory Effects of Bone Marrow‐Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant‐Induced Arthritis in Wistar Rats: Roles of IL‐1β, IL‐4, Nrf‐2, and Oxidative Stress

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Rheumatoid arthritis (RA) is a disorder triggered by autoimmune reactions and related with chronic inflammation and severe disability. Bone Marrow‐derived Mesenchymal Stem Cells (BM‐MSCs) have shown a hopeful immunomodulatory effect towards repairing cartilage and restoring joint function.
Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Emad A. Mahdi, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour, Arham Shabbir   +7 more
wiley   +1 more source

Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

Arthritis Research & Therapy, 2022
Abstract Objective Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering therapy (ULT) titration to target, we performed a prospective study of ...
Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan, Robert Terkeltaub   +11 more
openaire   +7 more sources

AB0084 Elevated levels of il-37 are associated with tophus and suppressed the production of inflammatory cytokines in patients with gout [PDF]

Annals of the Rheumatic Diseases, 2018
Background IL-37 has been identified as a natural inhibitor of innate immunity. Although increasing evidence shows elevated IL-37 expression in various autoimmune diseases, its correlation with clinical symptoms in gout is still unclear. Objectives This study aims to determine the correlation between the levels of IL-37 and clinical indexes in gout ...
X. Hong, L. Ding, Q. Huang, D. Liu
openaire   +1 more source

Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open‐label, single‐arm feasibility study in diabetic foot ulcers

International Wound Journal, Volume 17, Issue 5, Page 1366-1375, October 2020., 2020
Abstract Diabetic foot ulcers (DFUs) are a growing burden on patients and health care systems that often require multiple treatments of both conventional and advanced modalities to achieve complete wound closure. A novel autologous homologous skin construct (AHSC) has been developed to treat cutaneous defects with a single topical application, by ...
David G. Armstrong, Dennis P. Orgill, Robert Galiano, Paul M. Glat, Marissa Carter, Charles M. Zelen, William W. Li   +6 more
wiley   +1 more source

Prescribing Cascades with Recommendations to Prevent or Reverse Them:A Systematic Review [PDF]

, 2023
BACKGROUND: To reduce prescribing cascades occurring in clinical practice, healthcare providers require information on the prescribing cascades they can recognize and prevent.OBJECTIVE: This systematic review aims to provide an overview of prescribing ...
Adrien, Oriane, Denig, Petra, Hugtenburg, Jacqueline G, Karapinar-Carkıt, Fatma, McCarthy, Lisa M, Mohammad, Atiya K, Priester-Vink, Simone, van den Bemt, Patricia M L A, Visscher, Robbert   +8 more
core   +1 more source

AB0074 Daily exercise suppresses acute pro-inflammatory cytokine expression systemically and il-1Β locally in a murine model of gout [PDF]

Annals of the Rheumatic Diseases, 2018
Background Recent gout clinical practice recommendations/guidelines released by the ACR (2012) and the ACP (2017) do not address exercise as an interventional strategy; in contrast, the 2016 EULAR gout recommendations suggest that regular physical activity might decrease the excess mortality associated with chronic hyperuricemia.
N.A. Young, K. Jablonski, B. Sandoval, A. Kalyanasundaram, P. Harb, J. Hampton, W. Jarjour, N. Schlesinger   +7 more
openaire   +1 more source

Drug–drug interactions in vestibular diseases, clinical problems, and medico-legal implications [PDF]

, 2021
Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs ...
Chiarella G., Ciconte V., De Sarro G., Di Mizio G., Di Nunno N., Esposito M., Gallelli L., Marciano G., Muraca L., Palleria C., Piras A., Pisani D., Piscopo A., Raffi M., Rania V., Roberti R., Spaziano G., Viola P.   +17 more
core   +1 more source