Results 1 to 10 of about 48,143 (182)

Highly efficient production of HIV-1AD8 gp120 in mammalian cells [PDF]

Journal of Virology
Human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs) interact with the CD4 receptor and CCR5/CXCR4 coreceptor expressed on target cells to mediate viral entry. Infection is initiated when the HIV-1 gp120 subunit of Envs binds to host
Tanvi Mathur, Shamim Ahmed, Durgadevi Parthasarathy, Alon Herschhorn   +3 more
doaj   +2 more sources

Development of an Ultrasensitive ELISA Assay for Evaluating HIV-1 Envelope Glycoprotein as a Marker for Targeted Activator of Cell Kill [PDF]

Viruses
The HIV-1 envelope glycoprotein gp120 is prominently exposed on the surface of both HIV-1 virions and infected host cells, serving as a key marker of infection.
Guoxin Wu, Luca Sardo, Yuan Li, Steven D. Heron, BaoJen Shyong, Matthew Mazur, Daniel M. Gorman, Carl J. Balibar, Brian C. Magliaro, Craig Leach, Thomas Rush, Bonnie J. Howell   +11 more
doaj   +2 more sources

Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons [PDF]

Cell Death and Disease
People living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey, Lee A. Campbell, Thieu Phan, Gerard Ahern, Italo Mocchetti   +4 more
doaj   +2 more sources

Stoichiometry of HIV-1 envelope glycoprotein protomers with changes that stabilize or destabilize the pretriggered conformation [PDF]

mBio
During human immunodeficiency virus (HIV-1) entry into host cells, binding to the receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer ((gp120-gp41)3).
Zhiqing Zhang, Saumya Anang, Qian Wang, Hanh T. Nguyen, Hung-Ching Chen, Ta-Jung Chiu, Derek Yang, Amos B. Smith, Joseph G. Sodroski   +8 more
doaj   +2 more sources

Plugging gp120s Cavity [PDF]

Structure, 2008
NBD-556 is a class of HIV-1 entry inhibitors that binds HIV-1 surface glycoprotein gp120 and induces conformational changes, which mimic those caused by CD4 binding. Here, Madani et al. (2008) show that NBD-556 binds to the highly conserved "Phe-43 cavity" on gp120.
Repik, Alexander, Clapham, Paul R.
openaire   +4 more sources

Insight derived from molecular dynamics simulations into molecular motions, thermodynamics and kinetics of HIV-1 gp120. [PDF]

PLoS ONE, 2014
Although the crystal structures of the HIV-1 gp120 core bound and pre-bound by CD4 are known, the details of dynamics involved in conformational equilibrium and transition in relation to gp120 function have remained elusive.
Peng Sang, Li-Quan Yang, Xing-Lai Ji, Yun-Xin Fu, Shu-Qun Liu   +4 more
doaj   +1 more source

Few and Far Between: How HIV May Be Evading Antibody Avidity [PDF]

, 2010
No ...
Bjorkman, Pamela J., Klein, Joshua S.
core   +13 more sources

HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA. [PDF]

PLoS ONE, 2011
In addition to its role in virus entry, HIV-1 gp120 has also been implicated in HIV-associated neurocognitive disorders. However, the mechanism(s) responsible for gp120-mediated neuroinflammation remain undefined.
Ankit Shah, Ashish S Verma, Kalpeshkumar H Patel, Richard Noel, Vanessa Rivera-Amill, Peter S Silverstein, Suman Chaudhary, Hari K Bhat, Leonidas Stamatatos, Dhirendra P Singh, Shilpa Buch, Anil Kumar   +11 more
doaj   +1 more source

A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. [PDF]

PLoS ONE, 2010
Novel strategies are needed for the elicitation of broadly neutralizing antibodies to the HIV envelope glycoprotein, gp120. Experimental evidence suggests that combinations of antibodies that are broadly neutralizing in vitro may protect against ...
Hanna C Kelker, Vincenza R Itri, Fred T Valentine   +2 more
doaj   +1 more source

Physiological Corticosterone Attenuates gp120-Mediated Microglial Activation and Is Associated with Reduced Anxiety-Like Behavior in gp120-Expressing Mice

Viruses, 2023
Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system. Approximately half of all cART-treated patients contend with neurological impairments.
Emaya M. Moss, Fakhri Mahdi, Charlie J. Worth, Jason J. Paris   +3 more
doaj   +1 more source