Results 21 to 30 of about 48,162 (201)

HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents. [PDF]

PLoS ONE, 2011
Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) usually occurs late in the course of HIV-1 infection and the mechanisms underlying HAD pathogenesis are not well understood. Accumulating evidence indicates that neuronal voltage-gated
Lina Chen, Jianuo Liu, Changshui Xu, James Keblesh, Weijin Zang, Huangui Xiong   +5 more
doaj   +1 more source

Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study [PDF]

, 2008
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form.
Barrett, Tracey, Liu, Juan, Schlauch, Karen, Wang, Weifeng, Wheeler, David, Wu, Yuntao, Yoder, Alyson, Yu, Dongyang   +7 more
core   +3 more sources

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

eLife, 2015
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park, James Arthos, Claudia Cicala, John H Kehrl   +3 more
doaj   +1 more source

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Specific HIV gp120-cleaving Antibodies Induced by Covalently Reactive Analog of gp120 [PDF]

Journal of Biological Chemistry, 2003
We report the results of efforts to strengthen and direct the natural nucleophilic activity of antibodies (Abs) for the purpose of specific cleavage of the human immunodeficiency virus-1 coat protein gp120. Phosphonate diester groups previously reported to form a covalent bond with the active site nucleophile of serine proteases (Paul, S., Tramontano ...
Sudhir, Paul, Stephanie, Planque, Yong-Xin, Zhou, Hiroaki, Taguchi, Gita, Bhatia, Sangeeta, Karle, Carl, Hanson, Yasuhiro, Nishiyama   +7 more
openaire   +2 more sources

Molecular evolution of HIV-1 CRF01_AE Env in Thai patients. [PDF]

PLoS ONE, 2011
BACKGROUND: The envelope glycoproteins (Env), gp120 and gp41, are the most variable proteins of human immunodeficiency virus type 1 (HIV-1), and are the major targets of humoral immune responses against HIV-1.
Samatchaya Boonchawalit, Duangrat Jullaksorn, Jiraporn Uttiyoung, Amara Yowang, Nongkran Krathong, Sununta Chautrakul, Akifumi Yamashita, Kazuyoshi Ikuta, Amornsak Roobsoong, Sangkom Kanitvittaya, Pathom Sawanpanyalert, Masanori Kameoka   +11 more
doaj   +1 more source

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide [PDF]

, 2004
BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission.
A Robert Neurath, A Stone, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, B Conde-Petit, C Berset, C Ma, CD Pilcher, CD Rizzuto, CW Davis, DH Schwartz, DJ Bacon, E Poyrazoglu, EA Merritt, EG Cormier, G Zhang, H Blaak, H Brown, J Moore, JM Johnson, JP Moore, L Hammar, L Wu, M Hsu, M Seguchi, MA Skinner, N DeTommasi, N Mahmood, N Mahmood, Nathan Strick, P Langley, P Suphaphiphat, P Tomasik, P Westervelt, P Westervelt, PD Kwong, PJ Kraulis, Q Hu, Q Zhao, R Pantophlet, R Shattock, R Stute, R Weiss, RJ Shattock, RJ Shattock, RN Fichorova, RN Fichorova, RS Veazey, S Garg, S Gartner, S Laal, S Liu, S-T Hsu, SH Xiang, TC Pierson, UNAIDS, VJ Tomazic-Jezic, WC Greene, WR Yao, Y Van Herrewege, Yun-Yao Li   +66 more
core   +3 more sources

Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications

The Scientific World Journal, 2012
The blood-brain barrier (BBB) is compromised in many systemic and CNS diseases, including HIV-1 infection of the brain. We studied BBB disruption caused by HIV-1 envelope glycoprotein 120 (gp120) as a model.
Jean-Pierre Louboutin, David S. Strayer
doaj   +1 more source

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Gajbhiye, R, Gopal, S, Idicula-Thomas, S, Kishore, U, Kulkarni, V, Madan, T, Pandit, H, Patil, A, Qaseem, AS, Sonawani, A, Warke, H, Yadav, AK   +12 more
core   +3 more sources

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120

Beilstein Journal of Organic Chemistry, 2012
Based on the structure of the HIV-1 glycoprotein gp120 in complex with its cellular receptor CD4, we have designed and synthesized peptides that mimic the binding site of CD4 for gp120.
Julia Meier, Kristin Kassler, Heinrich Sticht, Jutta Eichler   +3 more
doaj   +1 more source