Results 141 to 150 of about 14,390 (160)
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gp130-Mediated Pathway and Heart Failure
Future Cardiology, 2008Binding of ligands to gp130 activates at least three different downstream signaling pathways: the signal transducer and activator of transcription (STAT), the Src-homology tyrosine phosphatase 2-ras-MAPK and the PI3K/Akt pathways. Cardiac-specific disruption of gp130 was shown to result in heart failure in response to mechano-stress accompanied by an ...
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SOCS3 regulates the plasticity of gp130 signaling
Nature Immunology, 2003Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathway. SOCS3 is upregulated by several signals in macrophages and has been implicated as a regulator of various signaling pathways.
Roland, Lang +7 more
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Down-Regulation of gp130 in Nasopharyngeal Carcinoma
American Journal of Rhinology & Allergy, 2009Background The purpose of this study was to explore the expression and biological functions of glycoprotein 130 (gp130) in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC). A prospective study was performed. Methods Ten patients with NPC and 10 patients with nasopharyngeal lymphoid hyperplasia (LH) were enrolled in this study.
Yung-Song, Lin +4 more
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gp130: a promising drug target for cancer therapy
Expert Opinion on Therapeutic Targets, 2013Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes. Dysregulation of gp130 expression, activation, or associated signaling pathways are implicated in a variety of ...
Shili, Xu, Nouri, Neamati
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Requirement of gp130 signaling for the AGM hematopoiesis
Experimental Hematology, 2003Definitive hematopoiesis starts in the aorta-gonad-mesonephros (AGM) region during mouse development and remarkably expands in the liver at a later stage of ontogeny. gp130 is a signal transducing receptor component shared by all the IL-6 family cytokines, whose gene ablation in mouse results in the significant reduction in the fetal liver ...
Makiko, Takizawa +6 more
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The Journal of Immunology, 2019
Abstract Rheumatoid arthritis is a chronic inflammatory disease that is characterized by joint destruction and inflammation by T helper 17 (Th17) cells. Interleukin-6 (IL-6) is secreted in cells such as macrophage or synovial fibroblast and induces the differentiation and function of Th17 cells that increase lymphocytic infiltration in ...
Yeon‐Hwa Park +2 more
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Abstract Rheumatoid arthritis is a chronic inflammatory disease that is characterized by joint destruction and inflammation by T helper 17 (Th17) cells. Interleukin-6 (IL-6) is secreted in cells such as macrophage or synovial fibroblast and induces the differentiation and function of Th17 cells that increase lymphocytic infiltration in ...
Yeon‐Hwa Park +2 more
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Chemical Biology & Drug Design, 2008
The transmembrane protein gp130 acts as the signal transducing receptor subunit for interleukin‐6 type cytokines, including viral interleukin‐6, which is encoded by the Kaposi’s sarcoma‐associated herpes virus. Viral interleukin‐6 has been shown to mimic human IL‐6 functions, including activation of the JAK1 and STAT1/3 signaling pathways. Based on the
Sudarman, Enge +6 more
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The transmembrane protein gp130 acts as the signal transducing receptor subunit for interleukin‐6 type cytokines, including viral interleukin‐6, which is encoded by the Kaposi’s sarcoma‐associated herpes virus. Viral interleukin‐6 has been shown to mimic human IL‐6 functions, including activation of the JAK1 and STAT1/3 signaling pathways. Based on the
Sudarman, Enge +6 more
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Gp130-mediated pathway and left ventricular remodeling
Journal of Cardiac Failure, 2002The binding of ligands to gp130 activates the JAK/STAT pathway, where STAT3 plays a central role in transmitting signals from the membrane to the nucleus. Cardiac-specific disruption of gp130 was shown to present heart failure in response to mechanical stress accompanied by an increase in apoptosis.
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Update of gp130 cytokines in multiple myeloma
Current Opinion in Hematology, 1998Interleukin (IL)-6 plays a major role in the control of the survival and proliferation of myeloma cell lines and primary myeloma cells. The genes of the receptors of IL-6 have been cloned, and the major signaling pathways involved in gp130 IL-6 transducer activation have been identified.
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Acquiring signalling specificity from the cytokine receptor gp130
Trends in Genetics, 2004Repeated use of a relatively small number of intracellular signalling molecules specifies tissue- and cell-type-specific responses to pleiotropic-acting growth factors and cytokines. Currently, gaining a better understanding of these mechanisms is a major challenge. The IL-6 family of cytokines shares a common receptor subunit called gp130.
Matthias, Ernst, Brendan J, Jenkins
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