Results 31 to 40 of about 29,098 (325)

Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD

International Journal of COPD, 2021
Zixiao Zhang,1,* Congli Fu,1,2,* Jiaxin Liu,1 Xiaoyan Sai,1 Chu Qin,1 Tingting Di,1 Yue Yang,1 Yan Wu,1 Tao Bian1 1Department of Respiratory Medicine, Wuxi People’s Hospital Affiliated to Nanjing, Medical University, Wuxi, Jiangsu, 214023, People’
Zhang Z, Fu C, Liu J, Sai X, Qin C, Di T, Yang Y, Wu Y, Bian T   +8 more
doaj  

Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases

Frontiers in Molecular Biosciences, 2022
Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui, Fei Yang, Fei Yang, Qian Li, Qian Li, Qian Li   +5 more
doaj   +1 more source

Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens [PDF]

, 2010
Lenses of adult Atlantic salmon fed with a plant oil and plant protein-based diet (plant diet) were compared to lenses of fish fed a diet based on traditional marine ingredients (marine diet) with respect to biochemical composition and functionality ex ...
Baslow, Bell, Bell, Bell, Bjerkås, Bjerkås, Bjerkås, Bjerkås, Breck, Breck, Breck, Breck, Brodtkorb, Chan, Christiane Tröβe, Delamere, Duston, Hargis, Hawse, Iwata, Jeremy D. Rhodes, Jobling, Jordal, Julie Sanderson, Kantorow, Lu, Menzies, Mizuno, Ng, Nilsen, Olav Breck, Rune Waagbø, Sneddon, Sutherland, Tacon, Toivonen, Torstensen, Torstensen, Torstensen, Tröβe, Tröβe, Turchini, Untergasser, Ursini, Vandesompele, Vemuri, Virtanen, Waagbø, Waagbø, Waagbø, Wall, Yeagle, Zhang   +52 more
core   +1 more source

Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]

, 2015
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi, Arne Holmgren, Chan PH, Chen EP, Chu FF, Daiber A, Elias S. J. Arnér, Geismann C, Hogan B, Jaarsma D, Jian-Hong Zhu, Jin R, Leitzmann C, Li JJ, Li JJ, Lu YP, Makino N, Miranda-Vizuete A, Mirochnitchenko O, Motoori S, Mulder DW, Ogata M, Oury TD, Papaioannou V, Radi R, Sandbach JM, Takahara S, Thimmulappa RK, Tome ME, Vogel U, Wang F, Wen JK, Wen-Hsing Cheng, Wispe JR, Woychik RP, Xin Gen Lei, Ye-Shih Ho, Yongping Bao, Yoshida T   +38 more
core   +1 more source

The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis

Molecular & Cellular Oncology, 2021
Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2).
Youwei Ai, Bo Yan, Xiaodong Wang
doaj   +1 more source

Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC)

Molecular & Cellular Oncology, 2021
Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis.
Christina M. Bebber, Silvia von Karstedt
doaj   +1 more source

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Biosensors, 2022
Glutathione peroxidase 4 (GPX4) plays an important effect on ferroptosis. Down-regulating the expression of GPX4 mRNA can decrease the content of GPX4. In this work, a gold nanoflare (AuNF) probe loaded with anti-sense sequences targeting for GPX4 mRNA ...
Xiaoyan Liu, Qiangqiang Yang, Yanan Sui, Qiaoli Yue, Shuqing Yan, Chuan Li, Min Hong   +6 more
doaj   +1 more source

Selenium and vascular health [PDF]

, 2011
Peer reviewedPublisher ...
Sneddon, Alan A.
core   +1 more source

Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice. [PDF]

PLoS ONE, 2014
PURPOSE: To evaluate the influence of glutathione peroxidase 4 (GPx4) expression in retinal pigment epithelium (RPE)/choroid tissue using a mouse model of laser-induced choroidal neovascularization (CNV).
Murilo Felix Roggia, Hirotaka Imai, Tomoyasu Shiraya, Yasuo Noda, Takashi Ueta   +4 more
doaj   +1 more source

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Antioxidants, 2022
Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined.
Xiaojie Ma, Xiaowu Dong, Yao Xu, Nan Ma, Mei Wei, Xiaochun Xie, Yingying Lu, Wangsen Cao, Guotao Lu, Weiqin Li   +9 more
doaj   +1 more source