Results 31 to 40 of about 5,253 (50)

FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

Journal of Advanced Research, 2023
Y. Bi, Shuolin Liu, X. Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang   +10 more
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GPX4, ferroptosis, and diseases.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Wangzheqi Zhang, Yang Liu, Yan Liao, Chenglong Zhu, Zui Zou   +4 more
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Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice.

Phytomedicine, 2023
Sixia Yang, Linshuang Wang, Yi Zeng, Yong Wang, Tingting Pei, Zeping Xie, Qiaowu Xiong, Huijuan Wei, Wenxu Li, Jiaqi Li, Qian Su, Dongfeng Wei, Weidong Cheng   +12 more
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Lipid peroxidation and ferroptosis: The role of GSH and GPx4.

Free Radical Biology & Medicine, 2020
F. Ursini, M. Maiorino
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Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy

Redox Biology
Chuying Huang, Yishan Guo, Tuo Li, Guo-gen Sun, Jinru Yang, Yuqi Wang, Ying Xiang, Li Wang, Min Jin, Jiao Li, Yong Zhou, Bing Han, Rui Huang, Jiao Qiu, Yong Tan, Jiaxing Hu, Yumiao Wei, Bo Wu, Yong Mao, Lingshan Lei, Xiusheng Song, Shuijie Li, Yongsheng Wang, Tao Zhang   +23 more
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology, 2014
J. Angeli, Manuela Schneider, B. Proneth, Y. Tyurina, V. Tyurin, V. Hammond, N. Herbach, M. Aichler, A. Walch, E. Eggenhofer, Devaraj Basavarajappa, O. Rådmark, Sho Kobayashi, Tobias Seibt, H. Beck, F. Neff, I. Esposito, R. Wanke, H. Förster, Olena Yefremova, Marc Heinrichmeyer, G. Bornkamm, E. Geissler, Stephen B. Thomas, B. Stockwell, V. O’Donnell, V. Kagan, Joel A. Schick, M. Conrad   +28 more
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Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

Science Translational Medicine, 2023
Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor therapy. However, current strategies not only selectively induce ferroptosis in malignant cells but also trigger ferroptosis in immune cells simultaneously, which can ...
Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent R. Stockwell, Guido Kroemer, Rui Kang, D. Tang   +9 more
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Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease

Journal of Pineal Research
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation of α‐synuclein (α‐syn). Ferroptosis, a form of cell death induced by iron accumulation and lipid peroxidation, is involved in ...
Qian-kun Lv, Kang-Xin Tao, Xiaoqin Yao, Meng-Zhu Pang, Bing-Er Cao, C. Liu, Fen Wang   +6 more
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USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy

Proceedings of the National Academy of Sciences of the United States of America
Significance Ferroptosis is pivotal in various physiological and pathological processes, yet our understanding of its mechanisms and implications for tissue homeostasis and cancer immunotherapy remains incomplete.
Haiou Li, Yishuang Sun, Yingmeng Yao, Shanwen Ke, Nannan Zhang, Wenjun Xiong, Jie Shi, Chuan He, Xiangling Xiao, Haisheng Yu, Panpan Dai, Bolin Xiang, Xixin Xing, Gaoshan Xu, Wenjing Song, Jiquan Song, Jinfang Zhang   +16 more
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BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers.

Cancer Discovery
Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) limits the therapeutic efficacy of PARP inhibition in treating breast cancer susceptibility gene 1 (BRCA1)-deficient cancers.
Guang Lei, Chao Mao, Amber Horbath, Yuelong Yan, Shirong Cai, Jun Yao, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Zhuang Li, Mei-Kuang Chen, Anagha Alapati, T. Yap, Mien-Chie Hung, M. J. You, H. Piwnica-Worms, Boyi Gan   +21 more
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