Results 31 to 40 of about 40,571 (376)
Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis
Frontiers in Immunology, 2022 Sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern (DAMP) that promotes inflammation and induces cell death via apoptosis, NETosis, and/or pyroptosis.
Junji Shimizu +9 more
openaire +3 more sources
MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. [PDF]
, 2018 We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal.
Abe, Hiroshi +10 more
core +3 more sources
Frontiers in Molecular Biosciences, 2022 Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui +5 more
doaj +1 more source
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
core +1 more source
Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition [PDF]
Bioscience Reports, 2020 Abstract It has been demonstrated from previous studies about the killing effect of dihydroartemisinin (DHA) on glioblastoma, which involves multiple aspects: cytotoxicity, cell cycle arrest and invasion inhibition. DHA has the advantages of low cytotoxicity to normal cells, selective killing effect and low drug resistance, making it ...
Renxin Yi +7 more
openaire +2 more sources
Redox Biology, 2021 The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors.
Jeffrey M. Stolwijk +6 more
doaj +1 more source
Structure–activity relationships of GPX4 inhibitor warheads
Bioorganic & Medicinal Chemistry Letters, 2020 Direct inhibition of GPX4 requires covalent modification of the active-site selenocysteine. While phenotypic screening has revealed that activated alkyl chlorides and masked nitrile oxides can inhibit GPX4 covalently, a systematic assessment of potential electrophilic warheads with the capacity to inhibit cellular GPX4 has been lacking. Here, we survey
John K. Eaton +4 more
openaire +3 more sources
Antioxidants, 2022 Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined.
Xiaojie Ma +9 more
doaj +1 more source
Nature Chemical Biology, 2020 Ferroptosis induced by GPX4 inhibition offers promise for killing drug-resistant cancer cells, yet current GPX4 inhibitors lack selectivity. The discovery of masked nitrile oxide electrophiles as selective prodrug inhibitors of GPX4 points to an attractive path for chemically inducing ferroptosis.
Stefan G. Kathman, Benjamin F. Cravatt
openaire +2 more sources
A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]
, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi +4 more
core +1 more source