Results 61 to 70 of about 40,571 (376)

Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression

EBioMedicine, 2022
Summary: Background: Osteoarthritis (OA) is the most common joint disease and is the leading cause of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) degradation was involved in OA pathogenesis. Ferroptosis was an
Yu Miao, Yiwei Chen, Feng Xue, Kexin Liu, Bin Zhu, Junjie Gao, Junhui Yin, Changqing Zhang, Guangyi Li   +8 more
doaj   +1 more source

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Nature Communications, 2021
Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient and energetically costly.
Yilei Zhang, Robert V. Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Zhuang Li, B. Fang, Junjie Chen, Shu‐Bing Qian, B. Gan   +16 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Gene expression profile of oxidative stress in the lung of inbred mice after intestinal ischemia/reperfusion injury [PDF]

, 2014
PURPOSE:To determine the gene expression profile associated with oxidative stress and antioxidant defense in the lung tissue of mice subjected to intestinal ischemia and reperfusion.METHODS:Twelve male, inbred mice (C57BL/6) were randomly assigned to one
Bertoletto, Eduardo Rodrigues, Bertoletto, Paulo Roberto, Chaves, Jose Carlos, Fagundes, Djalma José, Ikejiri, Adauto Tsutomu, Somaio Neto, Frederico, Taha, Murched Omar, Teruya, Roberto   +7 more
core   +3 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]

, 2011
The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core  

Tissue-Specific Orchestration of Gilthead Sea Bream Resilience to Hypoxia and High Stocking Density [PDF]

, 2019
Two different O-2 levels (normoxia: 75-85% O-2 saturation; moderate hypoxia: 42-43% O-2 saturation) and stocking densities (LD: 9.5, and HD: 19 kg/m(3)) were assessed on gilthead sea bream (Sparus aurata) in a 3-week feeding trial.
Ackerman, Alfaro, Almeida, Araújo-Luna, Arends, Ashley, Auer, Balasch, Benedito-Palos, Benedito-Palos, Benedito-Palos, Bergan-Roller, Bermejo-Nogales, Bermejo-Nogales, Bermejo-Nogales, Brett, Brown-Borg, Brown-Borg, Cadiz, Cadiz, Calduch-Giner, Calduch-Giner, Calduch-Giner, Dam, Deutsch, Du, Ekau, Estensoro, Everett, Føre, Gallaugher, Garcia de la Serrana, Gil-Solsona, Gómez-Requeni, Hermes-Lima, Hopkins, Huang, Hulbert, Hulbert, Jensen, Jørgensen, Kajimura, Ke, Kieffer, Lai, Larsen, Li, Livak, Lushchak, Magnoni, Martin, Martos-Sitcha, Martos-Sitcha, Martos-Sitcha, Martínez-Barberá, Martínez-Porchas, McKenzie, Millán-Cubillo, Minchenko, Mommsen, Monternier, Montero, Mosconi, Murray, Nikinmaa, Nikinmaa, Nilsson, Pauletto, Pearson, Person-Le Ruyet, Piazzon, Piazzon, Pichavant, Pickering, Poulain, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Reindl, Remen, Remen, Richards, Rimoldi, Rodrigues, Rolfe, Ruer, Salin, Sangiao-Alvarellos, Saravanan, Shimizu, Simó-Mirabet, Simó-Mirabet, Simó-Mirabet, Skrzynska, Soivio, Speckner, Treins, Val, Valli, Van Weerd, Vega-Rubín de Celis, Vijayan, Vikeså, Vélez, Wells, Wendelaar Bonga, Wold, Wood, Yu, Yáñez, Yúfera, Zhu   +113 more
core   +3 more sources

Distinct roles and molecular mechanisms of nicotine and benzo(a)pyrene in ferroptosis of lung adenocarcinoma and lung squamous cell carcinoma

Tobacco Induced Diseases
Introduction The essence of ferroptosis is the accumulation of membrane lipid peroxides caused by increased iron, which disrupts the redox balance within cells and triggers cell death.
Min G. Wen, Hui X. Zheng, Ying Z. Zhao, Pu Xia   +3 more
doaj   +1 more source

GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

BMC Cancer, 2022
Background Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail.
Sitian Wei, Zhicheng Yu, Rui Shi, Lanfen An, Qi Zhang, Qian Zhang, Tangansu Zhang, Jun Zhang, Hongbo Wang   +8 more
doaj   +1 more source

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation [PDF]

Nature Chemical Biology, 2018
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO2 is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in engineered cancer cells.
Michael M. Gaschler, Alexander A. Andia, Hengrui Liu, Joleen M. Csuka, Brisa Hurlocker, Christopher A. Vaiana, Daniel W. Heindel, Dylan S. Zuckerman, Pieter H. Bos, Eduard Reznik, Ling F. Ye, Yulia Y. Tyurina, Annie J. Lin, Mikhail S. Shchepinov, Amy Y. Chan, Eveliz Peguero-Pereira, Maksim A. Fomich, Jacob. D. Daniels, Andrei V. Bekish, Vadim V. Shmanai, Valerian E. Kagan, Lara K. Mahal, K. A. Woerpel, Brent R. Stockwell   +23 more
openaire   +4 more sources