Molecular pathways underlying amyloid precursor protein–mediated regulation of adult-born neurons
Neural Regeneration ResearchCleavage of amyloid precursor protein (APP) produces toxic amyloid-beta peptides, which play a critical role in the pathogenesis of Alzheimer’s disease. Neuronal loss is a key feature of Alzheimer’s disease.
Haidong Hu +12 more
doaj +1 more source
Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
Laboratory Animal Research, 2019 P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult and aged mice by using immunohistochemistry.
Tae-Kyeong Lee +8 more
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Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable. [PDF]
PLoS ONE, 2012 Computer simulations of external current stimulations of dentate gyrus granule cells of rats with Status Epilepticus induced by pilocarpine and control rats were used to evaluate whether morphological differences alone between these cells have an impact ...
Julián Tejada +3 more
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Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Brain Sciences, 2020 Preterm birth, a major contributor to infant mortality and morbidity, impairs development of the cerebellum, the brain region involved in cognitive processing and motor function.
Daniel Chizhikov +2 more
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Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. [PDF]
PLoS Computational Biology, 2014 Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial ...
Julian Tejada +2 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons
Frontiers in Cellular Neuroscience, 2018 The dentate gyrus (DG) receives highly processed information from the associative cortices functionally integrated in the trisynaptic hippocampal circuit, which contributes to the formation of new episodic memories and the spontaneous exploration of ...
Maryam Hatami +4 more
doaj +1 more source
Camillo Golgi on Cerebellar Granule Cells [PDF]
The Cerebellum, 2012 info:eu-repo/semantics ...
Mazzarello, Paolo +2 more
openaire +3 more sources