Results 31 to 40 of about 94,825 (337)

Gold Nanoparticles and Graphene Oxide Flakes Enhance Cancer Cells’ Phagocytosis through Granzyme-Perforin-Dependent Biomechanism

Nanomaterials, 2021
The study aimed to investigate the roles of gold nanoparticles (GNPs) and graphene oxide flakes (GOFs) as phagocytosis enhancers against cancer cells. The nanomaterials were characterized through SEM and UV-VIS absorptions.
Mohsen S. Al-Omar, M. Jabir, Esraa H. Karsh, Rua J. Kadhim, G. Sulaiman, Z. Taqi, K. Khashan, H. Mohammed, Riaz A. Khan, Salman A. A. Mohammed   +9 more
semanticscholar   +1 more source

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]

, 2010
Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Kuçi, Selim, Rettinger, Eva, Voß, Bernhard, Weber, Gerrit, Stais, Miriam, Kreyenberg, Hermann, Willasch, Andre Manfred, Kuçi, Zyrafete, Koscielniak, Ewa, Klöß, Stephan, Laer, Dorothee von, Klingebiel, Thomas, Bader, Peter   +12 more
core   +1 more source

Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells

Frontiers in Immunology, 2017
Interleukin-4 (IL-4) has been considered as one of the tolerogenic cytokines in many autoimmune animal models and clinical settings. Despite its role in antagonizing pathogenic Th1 responses, little is known about whether IL-4 possesses functions that ...
Wei-Cheng Yang, Wei-Cheng Yang, Yih-Shiou Hwang, Yih-Shiou Hwang, Ying-Yu Chen, Chao-Lin Liu, Chao-Lin Liu, Chia-Ning Shen, Wei-Hsin Hong, Sheng-Min Lo, Sheng-Min Lo, Chia-Rui Shen, Chia-Rui Shen, Chia-Rui Shen   +13 more
doaj   +1 more source

Feedback Regulation of Cathepsin C by the Propeptide Dipeptides of Granzymes A and B

Acta Chimica Slovenica, 2019
Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). However, the possible physiological role of the cleaved dipeptides Glu-Lys and Gly-Glu is not yet understood.
Janja Božič, Iztok Dolenc
doaj   +1 more source

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Journal of Biological Chemistry, 1997
There is compelling evidence that members of the caspase (interleukin-1β converting enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine protease granzyme B play essential roles in mammalian apoptosis.
N. Thornberry, T. Rano, E. Peterson, D. Rasper, Tracy Timkey, M. Garcia-Calvo, V. Houtzager, P. Nordstrom, Sophie Roy, J. Vaillancourt, K. Chapman, D. Nicholson   +11 more
semanticscholar   +1 more source

HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]

, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula, Braga, Sofia, Cabral, M. Guadalupe, Jacinto, António, Saraiva, Diana P.   +4 more
core   +2 more sources

Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy

Science Advances, 2020
Granzyme B nanoreporter can distinguish between highly responsive and poorly responsive tumors. Despite recent advancements in cancer immunotherapy, accurate monitoring of its efficacy is challenging due to heterogeneous immune responses.
Anh Nguyen, A. Ramesh, Sahana Kumar, Dipika Nandi, Anthony Brouillard, Alexandria C Wells, L. Pobezinsky, B. Osborne, A. Kulkarni   +8 more
semanticscholar   +1 more source

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells [PDF]

, 2017
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and
Adhikary, Adhikary, Adhikary, Ahn, Anderson, Annunziato, Appay, Appay, Aslan, Balfour, Battaglia, Baumjohann, Bickham, Bosselut, Britt, Brown, Brown, Brown, Brown, Brown, Bui, Cao, Cao, Cao, Carpenter, Casazza, Chen, Cheroutre, Chiu, Coler, de Souza, Deligeoroglou, Demachi-Okamura, Depil, Devarajan, Di Mitri, Dillon, Draenert, Duftner, Dumitriu, Endo, Enssle, Eshima, Facchinetti, Farrar, Faè, Fishman, Fleischer, Fontenot, Freeman, Fu, Fu, Gamadia, Gao, Garcia-Chagollan, Gasser, Geginat, Gelband, Goonetilleke, Grabowska, Grakoui, Grant, Grant, Groh, Ha, Haigh, Haque, Heaton, Hegde, Heller, Heusinkveld, Hildemann, Hislop, Hohler, Homma, Houser, Hua, Huz, Icheva, James, Jameson, Jeitziner, Johnson, Jones, Jones, Jonjic, Kadish, Kannanganat, Kaufmann, Kayagaki, Kenter, Kenter, Khanolkar, King, King, Kobayashi, Koel, Krensky, Kroesen, Kruger, Kuroda, Lazdina, Li, Libri, Lin, Loewendorf, Long, Long, Long, Long, Luckheeram, Lunemann, MacArthur, Mackay, Magnani, Malnati, Man, Manzke, Marshall, Martorelli, Mattapallil, McKinstry, McMichael, Merlo, Merlo, Metkar, Miamen, Moormann, Morales, Mosmann, Mucida, Munz, Munz, Murphy, Musey, Namekawa, Nemes, Nikiforow, Nixon, Norris, Oestreich, Omiya, O’Shea, Pachnio, Pachnio, Paludan, Pender, Peng, Penna, Piriou, Plata, Porakishvili, Qui, Quigley, Ratto-Kim, Reis, Rentenaar, Rerks-Ngarm, Ressing, Rosenberg, Sacha, Sakaguchi, Sallusto, Sandbulte, Savic, Scherrenburg, Schueller, Schulze zur Wiesch, Schulze Zur Wiesch, Schwartz, Seresini, Seresini, Soghoian, Soghoian, Spaete, Stacey, Steele, Streeck, Stuller, Su, Sun, Tagawa, Takeuchi, Tenzer, Terahara, Tewari, Thursz, Todryk, Tong, Toussirot, Trautmann, Trautmann, Trifari, Tscharke, Turnbull, Ulsenheimer, Vacchio, van de Berg, van den Hende, van Leeuwen, Vasin, Veldhoen, Ventura, Verma, Veronese, Voo, Voo, Vossen, Walker, Walton, Wang, Wang, Welters, Welters, WHO, Wilkinson, Wilson, Wilson, Wintermeyer, Workman, Xie, Xue, Yan, Yewdell, Zaunders, Zaunders, Zheng, Zhou, Zuo, zur Hausen   +229 more
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Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. [PDF]

PLoS ONE, 2012
Pancreatic beta cell destruction in type 1 diabetes is mediated by cytotoxic CD8(+) T lymphoctyes (CTL). Granzyme B is an effector molecule used by CTL to kill target cells.
Zia U Mollah, Kate L Graham, Balasubramanian Krishnamurthy, Prerak Trivedi, Thomas C Brodnicki, Joseph A Trapani, Thomas W Kay, Helen E Thomas   +7 more
doaj   +1 more source

Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer

Journal for ImmunoTherapy of Cancer, 2020
Background A minority of patients with advanced non-small-cell lung cancer (NSCLC) benefit from treatment with immune checkpoint inhibitors (ICIs). Ineffective effector function of activated T and NK cells may lead to reduced tumor cell death, even when ...
D. Hurkmans, E. A. Basak, Nina Schepers, E. Oomen‐de Hoop, C. H. van der Leest, S. el Bouazzaoui, S. Bins, S. Koolen, S. Sleijfer, A. A. van der Veldt, R. Debets, R. V. van Schaik, J. Aerts, R. Mathijssen   +13 more
semanticscholar   +1 more source