Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization [PDF]
Frontiers in Cellular Neuroscience, 2018 Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Alexa Kiss +4 more
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An Emerging Role of PRRT2 in Regulating Growth Cone Morphology [PDF]
Cells, 2021 Mutations in the PRRT2 gene are the main cause for a group of paroxysmal neurological diseases including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. In the mature central nervous system,
Elisa Savino +5 more
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A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: UNC-6/Netrin is a conserved bi-functional guidance cue which regulates dorsal-ventral axon guidance in C. elegans. In the Polarity/Protrusion model of UNC-6/Netrin mediated dorsal growth away from UNC-6/Netrin, The UNC-5 receptor first ...
Snehal S. Mahadik, Erik A. Lundquist
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The dynamics of growth cone morphology [PDF]
BMC Biology, 2015 Normal brain function depends on the development of appropriate patterns of neural connections. A critical role in guiding axons to their targets during neural development is played by neuronal growth cones.
G. Goodhill +8 more
semanticscholar +5 more sources
Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development
eLife, 2015 Filopodial dynamics are thought to control growth cone guidance, but the types and roles of growth cone dynamics underlying neural circuit assembly in a living brain are largely unknown.
Mehmet Neset Özel +3 more
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Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant [PDF]
eLife, 2023 A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities.
Alessandro Dema +4 more
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Mechanochemical regulation of growth cone motility [PDF]
Frontiers in Cellular Neuroscience, 2015 Neuronal growth cones are exquisite sensory-motor machines capable of transducing features contacted in their local extracellular environment into guided process extension during development.
Patrick C. Kerstein +2 more
semanticscholar +5 more sources
Neurotherapeutic Potential of Cervus elaphus Sibericus on Axon Regeneration and Growth Cone Reformation after H2O2-Induced Injury in Rat Primary Cortical Neurons [PDF]
Biology, 2021 Cervus elaphus sibericus (CES), commonly known as deer antler, has been used as a medicinal herb because of its various pharmacological activities, including its anti-infective, anti-arthritic, anti-allergic, and anti-oxidative properties.
Jin Young Hong +9 more
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Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration [PDF]
Frontiers in Neuroscience, 2020 The developing nervous system is a complex yet organized system of neurons, glial support cells, and extracellular matrix that arranges into an elegant, highly structured network.
Michael J. Rigby +8 more
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Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. [PDF]
Journal of Cell Biology, 1988 Actions of cytochalasin B (CB) on cytoskeletons and motility of growth cones from cultured Aplysia neurons were studied using a rapid flow perfusion chamber and digital video light microscopy.
Paul Forscher, Stephen J Smith
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