An Emerging Role of PRRT2 in Regulating Growth Cone Morphology [PDF]
Cells, 2021 Mutations in the PRRT2 gene are the main cause for a group of paroxysmal neurological diseases including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. In the mature central nervous system,
Elisa Savino +5 more
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A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: UNC-6/Netrin is a conserved bi-functional guidance cue which regulates dorsal-ventral axon guidance in C. elegans. In the Polarity/Protrusion model of UNC-6/Netrin mediated dorsal growth away from UNC-6/Netrin, The UNC-5 receptor first ...
Snehal S. Mahadik, Erik A. Lundquist
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Neurotherapeutic Potential of Cervus elaphus Sibericus on Axon Regeneration and Growth Cone Reformation after H2O2-Induced Injury in Rat Primary Cortical Neurons [PDF]
Biology, 2021 Cervus elaphus sibericus (CES), commonly known as deer antler, has been used as a medicinal herb because of its various pharmacological activities, including its anti-infective, anti-arthritic, anti-allergic, and anti-oxidative properties.
Jin Young Hong +9 more
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Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant [PDF]
eLife, 2023 A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities.
Alessandro Dema +4 more
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Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration [PDF]
Frontiers in Neuroscience, 2020 The developing nervous system is a complex yet organized system of neurons, glial support cells, and extracellular matrix that arranges into an elegant, highly structured network.
Michael J. Rigby +8 more
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β-catenin-α-catenin and actomyosin signaling differentially regulate growth cone contours and axon undulation and branching of retinal ganglion cells in situ [PDF]
Frontiers in Cellular NeuroscienceIntroductionCadherin adhesive and actomyosin signaling are key cytomechanical cues required for neuronal circuit formation, but whether they function together to sculpt developing neurons is not known. Previously, we demonstrated that a β-catenin mutant (
Valerie Lew +6 more
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Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment [PDF]
Cells, 2020 By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Ana Rita Costa, Monica M. Sousa
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Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes. [PDF]
Nat Protoc, 2022 Engmann AK +7 more
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Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2. [PDF]
Dev Neurobiol, 2021 Terzi A, Roeder H, Weaver CJ, Suter DM.
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Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies
Frontiers in Neuroscience, 2021 Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites.
Massimo M. Onesto +4 more
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