Stabilization of Actin Bundles by a Dynamin 1/Cortactin Ring Complex Is Necessary for Growth Cone Filopodia [PDF]
Journal of Neuroscience, 2013 Dynamin GTPase, a key molecule in endocytosis, mechanically severs the invaginated membrane upon GTP hydrolysis. Dynamin functions also in regulating actin cytoskeleton, but the mechanisms are yet to be defined.
Hiroshi Yamada +11 more
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Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization. [PDF]
Front Cell Neurosci, 2018 Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Kiss A +4 more
europepmc +2 more sources
Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes. [PDF]
Nat Protoc, 2022 Engmann AK +7 more
europepmc +3 more sources
Actin-based growth cone motility and guidance. [PDF]
Mol Cell Neurosci, 2017 Omotade OF, Pollitt SL, Zheng JQ.
europepmc +2 more sources
The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
Cold Spring Harbor Perspectives in Biology, 2011 Erik W. Dent +2 more
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Journal of Neuroscience, 2016 Spinal muscular atrophy (SMA) is a neurodegenerative disease primarily affecting spinal motor neurons. It is caused by reduced levels of the survival of motor neuron (SMN) protein, which plays an essential role in the biogenesis of spliceosomal small ...
C. Fallini +4 more
semanticscholar +1 more source
Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate
Journal of Neural Transplantation and Plasticity, 2016 Several important discoveries in growth cone cell biology were made possible by the use of growth cones derived from cultured Aplysia bag cell neurons, including the characterization of the organization and dynamics of the cytoskeleton.
Yuan Ren, D. Suter
semanticscholar +1 more source
Mechanochemical regulation of growth cone motility
Frontiers in Cellular Neuroscience, 2015 Neuronal growth cones are exquisite sensory-motor machines capable of transducing features contacted in their local extracellular environment into guided process extension during development.
Patrick C. Kerstein +2 more
semanticscholar +1 more source
Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development
eLife, 2015 Filopodial dynamics are thought to control growth cone guidance, but the types and roles of growth cone dynamics underlying neural circuit assembly in a living brain are largely unknown.
M. N. Özel +3 more
semanticscholar +1 more source
Journal of Neural Transplantation and Plasticity, 2015 Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan +7 more
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