An Emerging Role of PRRT2 in Regulating Growth Cone Morphology [PDF]
Cells, 2021 Mutations in the PRRT2 gene are the main cause for a group of paroxysmal neurological diseases including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. In the mature central nervous system,
Elisa Savino +5 more
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A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: UNC-6/Netrin is a conserved bi-functional guidance cue which regulates dorsal-ventral axon guidance in C. elegans. In the Polarity/Protrusion model of UNC-6/Netrin mediated dorsal growth away from UNC-6/Netrin, The UNC-5 receptor first ...
Snehal S. Mahadik, Erik A. Lundquist
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Neurotherapeutic Potential of Cervus elaphus Sibericus on Axon Regeneration and Growth Cone Reformation after H2O2-Induced Injury in Rat Primary Cortical Neurons [PDF]
Biology, 2021 Cervus elaphus sibericus (CES), commonly known as deer antler, has been used as a medicinal herb because of its various pharmacological activities, including its anti-infective, anti-arthritic, anti-allergic, and anti-oxidative properties.
Jin Young Hong +9 more
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Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant [PDF]
eLife, 2023 A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities.
Alessandro Dema +4 more
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Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration [PDF]
Frontiers in Neuroscience, 2020 The developing nervous system is a complex yet organized system of neurons, glial support cells, and extracellular matrix that arranges into an elegant, highly structured network.
Michael J. Rigby +8 more
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Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization [PDF]
Frontiers in Cellular Neuroscience, 2018 Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Alexa Kiss +4 more
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Regulation of growth cone motility [PDF]
Cell Motility, 1991 Nerve growth cones are the motile tips of elongating axons and dendrites. The migration and behavior of growth cones are responsible for axonal pathfinding to synaptic targets, and for the branching patterns of dendritic trees. Growth cones are studied at all levels of organization, molecular, cellular, and within intact embryos. Preparations of growth
Paul C. Letourneau, Christopher Cypher
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Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment [PDF]
Cells, 2020 By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Ana Rita Costa, Monica M. Sousa
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Model for Coordination of Microtubule and Actin Dynamics in Growth Cone Turning [PDF]
Frontiers in Cellular Neuroscience, 2018 In the developing nervous system, axons are guided to their synaptic targets by motile structures at the axon tip called growth cones, which reorganize their cytoskeleton in order to steer in response to chemotactic cues. Growth cone motility is mediated
Erin M. Craig
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Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies
Frontiers in Neuroscience, 2021 Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites.
Massimo M. Onesto +4 more
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