Results 31 to 40 of about 6,281,711 (333)
Journal of Neural Transplantation and Plasticity, 2015 Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan +7 more
semanticscholar +1 more source
Biomolecules, 2019 During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson +2 more
doaj +1 more source
Coupled local translation and degradation regulate growth cone collapse
Nature Communications, 2015 Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally synthesized, whereas most proteins are trafficked from the soma.
Alessia Deglincerti +5 more
semanticscholar +1 more source
Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones
Frontiers in Cellular Neuroscience, 2018 Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung +5 more
doaj +1 more source
Frontiers in Physiology, 2019 Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which ...
Regina Vontell +13 more
doaj +1 more source
Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development
Cells, 2021 During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets.
Samuel Laroche +5 more
doaj +1 more source
Translational regulation in growth cones [PDF]
Current Opinion in Genetics & Development, 2011 Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA repertoires in growing axons and ...
Hosung Jung +2 more
openaire +4 more sources
Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons
eLife, 2015 During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor ...
Timothy A Evans +3 more
doaj +1 more source
BMC Biology, 2014 BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
M. Liz +12 more
semanticscholar +1 more source
Cell Reports, 2017 During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little ...
Anaïs Bellon +14 more
doaj +1 more source