Results 31 to 40 of about 152,389 (315)
Biomolecules, 2019 During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson +2 more
doaj +1 more source
Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones
Frontiers in Cellular Neuroscience, 2018 Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung +5 more
doaj +1 more source
Cell Reports, 2017 During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little ...
Anaïs Bellon +14 more
doaj +1 more source
Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development
Cells, 2021 During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets.
Samuel Laroche +5 more
doaj +1 more source
The Role of Apoptotic Signaling in Axon Guidance
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
doaj +1 more source
Translational regulation in growth cones [PDF]
Current Opinion in Genetics & Development, 2011 Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA repertoires in growing axons and ...
Hosung Jung +2 more
openaire +4 more sources
Frontiers in Physiology, 2019 Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which ...
Regina Vontell +13 more
doaj +1 more source
Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons
eLife, 2015 During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor ...
Timothy A Evans +3 more
doaj +1 more source
Anomalous diffusion for neuronal growth on surfaces with controlled geometries [PDF]
Published in PLOS ONE, 14(5), e0216181, May 6, 2019, 2019 Geometrical cues are known to play a very important role in neuronal growth and the formation of neuronal networks. Here, we present a detailed analysis of axonal growth and dynamics for neuronal cells cultured on patterned polydimethylsiloxane surfaces.
arxiv +1 more source
Frontiers in Neuroscience, 2022 Dual specificity tyrosine-phosphorylation-regulated kinases (DYRKs) are a group of conserved eukaryotic kinases phosphorylating tyrosine, serine, and threonine residues. The human DYRK family comprises 5 members (DYRK1A, DYRK1B, DYRK2, DYRK3, and DYRK4).
Gabriel Nicolás Santos-Durán +1 more
doaj +1 more source