Results 41 to 50 of about 6,281,711 (333)

The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP

Development, 2014
UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40–UNC-5 heterodimers
Adam D Norris, Lakshmi Sundararajan, D. E. Morgan, Z. Roberts, E. Lundquist   +4 more
semanticscholar   +1 more source

The Role of Apoptotic Signaling in Axon Guidance

Journal of Developmental Biology, 2018
Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer, Leah M. Heydman, Grant S. Mastick, Thomas Kidd   +3 more
doaj   +1 more source

Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton*

Journal of Biological Chemistry, 2014
Background: Intricate regulation of the growth cone cytoskeleton controls growth cone dynamics. Results: Loss of CRMP4 disrupts growth cone cytoskeletal dynamics, growth cone expansion, and axon growth.
M. Khazaei, Marie-Pier Girouard, R. Alchini, Stephan Ong Tone, Tadayuki Shimada, S. Bechstedt, M. Cowan, D. Guillet, P. Wiseman, G. Brouhard, J. Cloutier, A. Fournier   +11 more
semanticscholar   +1 more source

Roles of dual specificity tyrosine-phosphorylation-regulated kinase 2 in nervous system development and disease

Frontiers in Neuroscience, 2022
Dual specificity tyrosine-phosphorylation-regulated kinases (DYRKs) are a group of conserved eukaryotic kinases phosphorylating tyrosine, serine, and threonine residues. The human DYRK family comprises 5 members (DYRK1A, DYRK1B, DYRK2, DYRK3, and DYRK4).
Gabriel Nicolás Santos-Durán, Antón Barreiro-Iglesias   +1 more
doaj   +1 more source

The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent

Journal of Neuroscience, 2014
During development extrinsic guidance cues modulate the peripheral actin network in growth cones to direct axons to their targets. We wanted to understand the role of the actin nucleator Arp2/3 in growth cone actin dynamics and guidance.
José E San Miguel-Ruiz, Paul C. Letourneau   +1 more
semanticscholar   +1 more source

Val66Met Polymorphism of BDNF Alters Prodomain Structure to Induce Neuronal Growth Cone Retraction

Nature Communications, 2013
A common single-nucleotide polymorphism (SNP) in the human brain-derived neurotrophic factor (BDNF) gene results in a Val66Met substitution in the BDNF prodomain region.
A. Anastasía, K. Deinhardt, M. Chao, N. Will, Krithi Irmady, F. Lee, B. Hempstead, C. Bracken   +7 more
semanticscholar   +1 more source

Frataxin Deficit Leads to Reduced Dynamics of Growth Cones in Dorsal Root Ganglia Neurons of Friedreich’s Ataxia YG8sR Model: A Multilinear Algebra Approach

Frontiers in Molecular Neuroscience, 2022
Computational techniques for analyzing biological images offer a great potential to enhance our knowledge of the biological processes underlying disorders of the nervous system. Friedreich’s Ataxia (FRDA) is a rare progressive neurodegenerative inherited
Diana C. Muñoz-Lasso, Belén Mollá, Belén Mollá, Jhon J. Sáenz-Gamboa, Jhon J. Sáenz-Gamboa, Jhon J. Sáenz-Gamboa, Edwin Insuasty, Maria de la Iglesia-Vaya, Maria de la Iglesia-Vaya, Maria de la Iglesia-Vaya, Mark A. Pook, Federico V. Pallardó, Federico V. Pallardó, Federico V. Pallardó, Francesc Palau, Francesc Palau, Francesc Palau, Pilar Gonzalez-Cabo, Pilar Gonzalez-Cabo, Pilar Gonzalez-Cabo   +19 more
doaj   +1 more source

Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance

Journal of Neuroscience, 2013
How growth cones detect small concentration differences of guidance cues for correct steering remains a long-standing puzzle. Commissural axons engage planar cell polarity (PCP) signaling components to turn anteriorly in a Wnt gradient after midline ...
Keisuke Onishi, B. Shafer, C. Lo, F. Tissir, A. Goffinet, Y. Zou   +5 more
semanticscholar   +1 more source

Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway

Frontiers in Neural Circuits, 2020
Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake, Yoshio Goshima, Yukio Sasaki   +2 more
doaj   +1 more source

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration

eLife, 2016
Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Hyo Rim Ko, Il-Sun Kwon, Inwoo Hwang, Eun-Ju Jin, Joo-Ho Shin, Angela M Brennan-Minnella, Raymond Swanson, Sung-Woo Cho, Kyung-Hoon Lee, Jee-Yin Ahn   +9 more
doaj   +1 more source