Results 41 to 50 of about 152,389 (315)
Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development
eLife, 2015 Filopodial dynamics are thought to control growth cone guidance, but the types and roles of growth cone dynamics underlying neural circuit assembly in a living brain are largely unknown.
Mehmet Neset Özel +3 more
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Frontiers in Molecular Neuroscience, 2022 Computational techniques for analyzing biological images offer a great potential to enhance our knowledge of the biological processes underlying disorders of the nervous system. Friedreich’s Ataxia (FRDA) is a rare progressive neurodegenerative inherited
Diana C. Muñoz-Lasso +19 more
doaj +1 more source
Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
doaj +1 more source
Warped quasi-asymptotically conical Calabi-Yau metrics [PDF]
arXiv, 2023 We construct many new examples of complete Calabi-Yau metrics of maximal volume growth on certain smoothings of Cartesian products of Calabi-Yau cones with smooth cross-sections. A detailed description of the geometry at infinity of these metrics is given in terms of a compactification by a manifold with corners obtained through the notion of weighted ...
arxiv
eLife, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Hyo Rim Ko +9 more
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Advanced Science, 2021 Neurovascular disorders, which involve the vascular and nervous systems, are common. Research on such disorders usually focuses on either vascular or nervous components, without looking at how they interact.
Idoia Elorza Ridaura +2 more
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A new view of axon growth and guidance grounded in the stochastic dynamics of actin networks
Open Biology, 2023 The mechanism of axon growth and guidance is a core, unsolved problem in neuroscience and cell biology. For nearly three decades, our view of this process has largely been based on deterministic models of motility derived from studies of neurons cultured
Rameen Forghani +3 more
doaj +1 more source
Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders
Cells, 2020 Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the ...
Diana C. Muñoz-Lasso +3 more
doaj +1 more source
Mechanochemical regulation of growth cone motility [PDF]
Frontiers in Cellular Neuroscience, 2015 Neuronal growth cones are exquisite sensory-motor machines capable of transducing features contacted in their local extracellular environment into guided process extension during development. Extensive research has shown that chemical ligands activate cell surface receptors on growth cones leading to intracellular signals that direct cytoskeletal ...
Patrick C Kerstein +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source