Results 231 to 240 of about 5,060,755 (278)

Microtubule organization in growth cones

Biochemical Society Transactions, 1991
Neuronal growth cones guide growing axons and dendrites (neurites) through developing embryos by detecting extrinsic guidance cues and transducing the signal into changes in motile behavior. In this chapter, the role of the growth cone cytoskeleton in these events, in particular the microtubules, is discussed.
openaire   +3 more sources

Growth Cone Collapse Assay

2014
The growth cone collapse assay has proved invaluable in detecting and purifying axonal repellents. Glycoproteins/proteins present in detergent extracts of biological tissues are incorporated into liposomes, added to growth cones in culture and changes in morphology are then assessed.
Geoffrey M W, Cook, Prem, Jareonsettasin, Roger J, Keynes   +2 more
openaire   +2 more sources

Microtubules and growth cone function

Journal of Neurobiology, 2003
AbstractIt has been recognized for a long time that the neuronal cytoskeleton plays an important part in neurite growth and growth cone pathfinding, the mechanism by which growing axons find an appropriate route through the developing embryo to their target cells.
openaire   +3 more sources

Neuronal growth cone migration

Experientia, 1990
The neuronal growth cone is a semi-autonomous portion of the developing neuron that is highly specialized for motile activity. Migrating neurons may share some features with neuronal growth cones. I review some of what has been learned about growth cone initiation, the differentiation of axons and dendrites, the role of the cytoskeleton in motility ...
openaire   +2 more sources

Morphogens as growth cone signalling molecules

Brain Research Reviews, 2005
Morphogen signalling among cells is one of the most important mechanisms underlying the progressive patterning of embryos. Members of the hedgehog (Hh), wingless (Wnt), transforming growth factor-beta (TGFbeta), and fibroblast growth factor (Fgf) families of extracellular signalling molecules act as morphogens.
Cristina, Sánchez-Camacho, Josana, Rodríguez, José María, Ruiz, Françoise, Trousse, Paola, Bovolenta   +4 more
openaire   +2 more sources

Autonomous regulation of growth cone filopodia

Journal of Neurobiology, 1998
The fan-shaped array of filopodia is the first site of contact of a neuronal growth cone with molecules encountered during neuronal pathfinding. Filopodia are highly dynamic structures, and the "action radius" of a growth cone is strongly determined by the length and number of its filopodia.
V, Rehder, S, Cheng
openaire   +2 more sources

Growth Cone Guidance

Science's STKE, 2004
The semaphorin family of guidance cues act predominantly through plexin receptors at the surface of various cell types. The small guanosine triphosphatases (GTPases) Rho and Rac have been implicated as downstream effectors of semaphorin-plexin interactions that modulate the cytoskeleton, but details of how plexins activate these GTPases ...
openaire   +1 more source

Sites of plasmalemmal expansion in growth cones

Developmental Brain Research, 1993
Studies on plasmalemmal expansion in isolated nerve growth cones identified large, clear vesicles characteristically found in growth cones as the plasmalemmal precursor. The present article examines these plasmalemmal precursor vesicles (PPVs) in greater detail in the intact cell.
K H, Pfenninger, L B, Friedman
openaire   +2 more sources

Rapid effects of laminin on the growth cone

Neuron, 1992
To gain insight into how laminin promotes neurite growth, high resolution video microscopy was used to determine the rapid effects of laminin on growth cone structure. Sympathetic growth cones in serum-free medium on polylysine substrate displayed extensive motility and protrusive activity and often had large lamellipodia.
R J, Rivas, D W, Burmeister, D J, Goldberg   +2 more
openaire   +2 more sources

Can there be growth without growth cones?

Seminars in Neuroscience, 1996
Abstract In-vivo imaging of the development of complex retinotectal axon arbors indicates that arbors branches can form and extend in the absence of growth cones. A variety of imaging protocols were used to observe arbor elaboration over a range of time intervals and total observation periods.
openaire   +1 more source