Journal of Biological Chemistry, 2006 Originally thought of as a stomach-derived endocrine peptide acting via its receptors in the central nervous system to stimulate food intake and growth hormone expression, ghrelin and its receptor (growth hormone secretagogue receptor (GHS-R)) are widely
V. Dixit +7 more
semanticscholar +1 more source
Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts. [PDF]
, 2015 Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis,
Casati, L +5 more
core +4 more sources
Frontiers in Nutrition, 2015 The gastrointestinal peptide hormone ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR, a.k.a. ghrelin receptor, GHR). Currently, ghrelin is the only circulating peripheral hormone with the ability to promote a positive ...
Katrin eFischer +5 more
doaj +1 more source
Growth Hormone (GH)-Releasing Hormone (GHRH) and the GH Secretagogue (GHS), L692,585, Differentially Modulate Rat Pituitary GHS Receptor and GHRH Receptor Messenger Ribonucleic Acid Levels [PDF]
, 1999 Rhonda D. Kineman
openalex +1 more source
The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus [PDF]
, 2007 The G protein-coupled receptor 39 (GPR39) has recently been identified as the receptor for obestatin, a peptidic hormone involved in energy homeostasis.
Catalan, V. (Victoria) +8 more
core +1 more source
Sodium is a negative allosteric regulator of the ghrelin receptor
Cell Reports, 2023 Summary: The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment.
Guillaume Ferré +8 more
doaj
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
core +2 more sources
Establishment of a Cell Line Stably Expressing the Growth Hormone Secretagogue Receptor to Identify Crocin as a Ghrelin Agonist. [PDF]
Biomolecules, 2022 Wang CH, Tseng CY, Hsu WL, Tzen JTC.
europepmc +1 more source
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]
, 2014 G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F +12 more
core +4 more sources
Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus.
PLoS ONE, 2010 BackgroundGhrelin targets the arcuate nucleus, from where growth hormone releasing hormone (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains neuropeptide Y (NPY) neurons which play a master role in the effect of ghrelin on ...
Guillaume Osterstock +12 more
doaj +1 more source