Results 41 to 50 of about 60,269 (268)

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity [PDF]

Journal of Clinical Investigation, 2002
Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. Ghrelin, an endogenous ligand for GHS-R, has recently been purified from rat stomach.
Yujin Shuto, Tamotsu Shibasaki, Asuka Otagiri, Hideki Kuriyama, Hisayuki Ohata, Hideki Tamura, Jun Kamegai, Hitoshi Sugihara, Shinichi Oikawa, Ichiji Wakabayashi   +9 more
openalex   +4 more sources

Ghrelin and the growth hormone secretagogue receptor in growth and development [PDF]

International Journal of Obesity, 2009
The pancreas is a major source of ghrelin in the perinatal period, whereas gastric production progressively increases after birth. Loss of function of the genes for ghrelin or for the constitutively activated growth hormone secretagogue receptor (GHSR) does not affect birth weight and early postnatal growth.
K. De Waele, Pallavi Walia, Jean-Pierre Chanoine   +2 more
openaire   +3 more sources

Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice

Neuroendocrinology, 2021
Introduction: While the vast majority of research investigating the role of ghrelin or its receptor, GHS-R1a, in growth, feeding, and metabolism has been conducted in male rodents, very little is known about sex differences in this system.
A. Labarthe, P. Zizzari, O. Fiquet, N. Lebrun, J. Veldhuis, F. Roelfsema, C. Chauveau, M. Bohlooly-y, J. Epelbaum, V. Tolle   +9 more
semanticscholar   +1 more source

The Involvement of the GH/IGF-I Axis in Cognitive Functions of Adult Patients and Healthy Subjects [PDF]

, 2012
Objective: To clarify the metabolic effects of an overnight i.v. infusion of unacylated ghrelin (UAG) in humans. UAG exerts relevant metabolic actions, likely mediated by a still unknown ghrelin receptor subtype, including effects on β-cell viability and
Deijen, J.B., Drent, M.L., Driel, M.I.
core   +7 more sources

Growth hormone secretagogues: history, mechanism of action, and clinical development

JCSM Rapid Communications, 2020
Growth hormone secretagogues (GHSs) are a generic term to describe compounds that increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the growth
Junichi Ishida, Masakazu Saitoh, Nicole Ebner, Jochen Springer, Stefan D. Anker, Stephan vonHaehling   +5 more
doaj   +1 more source

Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor [PDF]

Journal of Biological Chemistry, 2000
Ghrelin, a peptide purified from the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and potently stimulates growth hormone release from the pituitary. Ghrelin is modified with an n-octanoyl group at Ser3.
Hiroshi Hosoda, Masayasu Kojima, Hisayuki Matsuo, Kenji Kangawa   +3 more
openalex   +2 more sources

Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]

, 2011
The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge, Josh, Peter, Cunningham, Peter, Herington, Adrian, Chopin, Lisa K.   +4 more
core   +2 more sources

The growth hormone secretagogue receptor

Growth Hormone & IGF Research, 1999
The specific human growth hormone (GH) secretagogue receptor (type la) was cloned in 1996 using the nonpeptide GH secretagogue MK-0677 as a ligand. 1,2 It belongs to the G-protein coupled seven transmembrane domain receptor family, but does not show close homology with any of the known subgroups of receptors, though its sequence is conserved between ...
KORBONITS M., CICCARELLI E., GHIGO, Ezio, GROSSMAN AB   +3 more
openaire   +4 more sources

Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]

, 2018
Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael, Juan Rodríguez, Rocío, Kandil, Dalia, McGlacken, Gerard P., Pastor Cavada, Elena, Schellekens, Harriët, Shaban, Hamdy, Shanahan, Rachel, Torres-Fuentes, Cristina   +8 more
core   +3 more sources

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain. [PDF]

Brain Struct Funct
Abstract The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses.
Saenz C, Fernandez G, Llovera R, Tolosa MJ, Cantel S, Fehrentz JA, Mackie K, Leggio L, Zigman J, De Francesco PN, Perello M.   +10 more
europepmc   +4 more sources