Results 121 to 130 of about 5,144 (202)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science
Pyroptosis has attracted significant attention for its role in cancer chemotherapy and immunotherapy. However, few drugs have been reported to induce pyroptosis via the Caspase‐3/gasdermin E (GSDME) pathway.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
doaj   +1 more source

Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy-Treated Melanoma. [PDF]

Cancer Immunol Res
Wilski-Cronin NA, Erkes DA, Purwin TJ, Melissaratos DS, Stefanski CD, Caksa S, Kitterman E, Heilizer JS, Chervoneva I, Fernandes-Alnemri T, Alnemri ES, Aplin AE.   +11 more
europepmc   +1 more source

Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice. [PDF]

Microbiol Spectr
Speaks S, Papa J, McFadden M, Roettger JE, Liu BD, Mohan S, Reznik BM, Leumi S, Cable JM, Forero A, Yount JS.   +10 more
europepmc   +1 more source

GSDME-mediated pyroptosis is essential for the chemotherapeutic effects achieved by combined treatment of temsirolimus and 5-fluorouracil in ovarian carcinoma cells. [PDF]

Am J Transl Res
Chen Z, Ye M, Gu C, Wen N, Wang N, Meng Y.   +5 more
europepmc   +1 more source

IKBKE downregulation increases chemosensitivity through pyroptosis mediated by the caspase-3/GSDME pathway in pancreatic cancer. [PDF]

J Exp Clin Cancer Res
Ren T, Chen X, Wang X, Xu Y, Shao N.
europepmc   +1 more source

Harnessing pyroptosis in breast cancer therapy: immunological mechanisms and emerging biomaterial strategies. [PDF]

Cell Death Discov
Asiedu RKF, Souley Abdou M, Wei R, Xiao Z, Li B, Hu M.   +5 more
europepmc   +1 more source

Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis. [PDF]

Blood Adv
Kong X, Xu-Monette ZY, Xu Z, Hsi ED, Zhao X, Yan H, Nunns H, Au K, Visco C, Tzankov A, Dybkaer K, Yao S, Wu D, Wang C, Xu AM, Pan Z, Parsons BM, Chiu A, Tam W, Montes-Moreno S, Zhan F, Bernal-Mizrachi L, Zu Y, Zhang S, Møller MB, Chen W, Au Q, Merchant A, Bhagat G, Li Y, Young KH.   +30 more
europepmc   +1 more source

FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis. [PDF]

Int J Biol Sci
Wang Y, Wang Y, Cui Y, He Y, Yang Y, Zhou W, Liu L, Wang H, Liu M, Wei Y, Huang Z, Wei X, Mao X.   +12 more
europepmc   +1 more source

A novel non-sense variant in <i>GSDME</i> causing exon skipping associated with DFNA5 in a large Chinese family. [PDF]

Front Neurol
Yang B, Zhu M, Long X, Wan S, Lu Y, Yuan H, Hua Q.   +6 more
europepmc   +1 more source

The molecular mechanisms of pyroptosis and its implications in tumor immunotherapy. [PDF]

Mol Cancer
Chen G, Zhang Z, Chong W, Qiu G, Li Z, Yang S, Pan X, Ma T, Lian G, Wang X, Li L, Tian F, Jing C.   +12 more
europepmc   +1 more source