PRECLINICAL EVALUATION OF IMMUNOMODULATORY EFFECTS OF AURORA KINASE INHIBITION IN HUMAN PAPILLOMAVIRUS POSITIVE CANCERS [PDF]
, 2023 Human papillomavirus (HPV) is the causative agent of cervical cancer and some cancers of the penis, vulva, vagina, anus, and oropharynx. Current therapies for these cancers include a combination of surgery, radiotherapy, and chemotherapy that often ...
Sinha, Pragya
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IL2RG knockout mitigates polycystic ovary syndrome pathogenesis by transitioning pyroptosis to apoptosis through the GSDME pathway. [PDF]
J Ovarian ResPolycystic ovary syndrome (PCOS) is a common endocrine disorder with significant impacts on women’s reproductive health. Interleukin (IL)-2 receptor subunit gamma (IL2RG), a common receptor for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, has been shown to ...
Chen S +10 more
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Frontiers in Cell and Developmental BiologyBackgroundBone marrow (BM) suppression is the most prevalent dose-limiting side effect of chemotherapy and radiotherapy. Exposure to ionizing radiation (IR) results in acute BM suppression and long-term BM injury.
Lulu Su +10 more
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NLRP1 and gasdermins regulate IL-1β release in human lung fibroblasts infected with respiratory syncytial virus [PDF]
Respiratorisk syncytialvirus (RSV) er en hovedårsak til akutte infeksjoner i luftveiene, spesielt hos spedbarn og eldre. Det inflammatoriske cytokinet interleukin-1β (IL-1β) har vist seg å spille en kritisk rolle i balansen mellom virusindusert celledød ...
Veronika, Tiszlavicz
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Assessing the role of JNK in human endothelial cell death induced by anti-cancer therapies [PDF]
Cardiovascular disease is a common side effect of cancer treatment, particularly in those who have been disease-free for over 10 years. Several studies have shown that radiation and chemotherapeutics, such as Doxorubicin and Cisplatin, can induce ...
McCulloch, Ashley
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Dynamic regulation of cell death signaling [PDF]
There are many ways for a cell to die, but each cell only dies once, causing an inherent variability that results from common triggers activating interconnected signaling networks that diverge at key decision points during cell death initiation ...
Garcia-Saez, A. , Majoul, A.
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Advanced ScienceDrug‐induced liver injury (DILI) is a significant global health issue that poses high mortality and morbidity risks. One commonly observed cause of DILI is acetaminophen (APAP) overdose. GSDME is an effector protein that induces non‐canonical pyroptosis.
Shen‐Xi Ouyang +15 more
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Mitochondrial dynamics and pore formation in regulated cell death pathways [PDF]
Mitochondria act as central hubs for cell death signaling. During apoptosis and regulated necrosis (pyroptosis, necroptosis, and ferroptosis), mitochondria undergo drastic changes including membrane permeabilization, fragmentation, and loss of membrane ...
Garcia-Saez, A. , Hohorst, L., Ros, U.
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HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway [PDF]
, 2020 Gao Tan +3 more
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