Accelerating functional gene discovery in osteoarthritis. [PDF]
, 2021 Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset or progression.
Adams, David J +26 more
core +10 more sources
Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells
Cell Communication and Signaling, 2023 Background Lung cancer is the most lethal malignancy, with non-small cell lung cancer (NSCLC) being the most common type (~ 85%). Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC.
Limei Xu +7 more
doaj +1 more source
Biomedicines, 2023 The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset.
Shiyao Xie +7 more
doaj +1 more source
Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease [PDF]
Investigative Ophthalmology and Visual SciencePurpose Dry eye disease (DED) is a common ocular surface inflammatory disease with a complex pathogenesis. Herein, the role and effect of gasdermin E (GSDME) in DED pathogenesis were explored. Methods In vitro, flow cytometry, Cell Counting Kit-8 (CCK-8)
Ling Wang +5 more
openalex +2 more sources
Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]
, 2023 Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate immune ...
Baran, Marcin +4 more
core +2 more sources
Recombinant DnaK orally administered protects axenic European sea bass against vibriosis [PDF]
, 2020 Vibrio anguillarum causes high mortality in European sea bass (Dicentrarchus labrax) larviculture and is a hindering factor for successful sustainable aquaculture of this commercially valuable species.
Bajek, Aline +6 more
core +2 more sources
CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma [PDF]
, 2022 Therapy resistance, which leads to the development of loco-regional relapses and distant metastases after treatment, constitutes one of the major problems that head and neck squamous cell carcinoma (HNSCC) patients currently face. Thus, novel therapeutic
Alba-Castellón, Lorena +13 more
core +1 more source
Secondary Necrosis Following Caspase-Activation can Occur Independently of Gasdermin E. [PDF]
Adv Sci (Weinh)Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple models, secondary necrosis occurred regardless of gasdermin E presence, challenging prior claims and redefining the understanding of how apoptotic cells ...
Gavali S +9 more
europepmc +2 more sources
The multifaceted roles of gasdermins in cancer biology and oncologic therapies [PDF]
, 2021 The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA, B, C, D, GSDME/DFNA5 and PJVK/ DFNB59) and, except PJVK, they can trigger ...
Martinez-Val, Jeannette +4 more
core +1 more source
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis
Frontiers in Oncology, 2021 Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang +6 more
doaj +1 more source