Results 51 to 60 of about 5,144 (202)

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling [PDF]

, 2022
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18.
Abu-Amer, Yousef, Alippe, Yael, Brodt, Michael D, Hao, Dingjun, Hu, Huimin, Mbalaviele, Gabriel, Shen, Jie, Silva, Matthew J, Sun, Kai, Wang, Chun, Xiao, Jianqiu, Yang, Tong, Yuan, Luorongxin   +12 more
core   +2 more sources

Activation of GSDME by Lithospermum erythrorhizon drives pyroptotic cell death

Journal of Traditional Chinese Medical Sciences, 2023
Objective: To reveal GSDME-executed pyroptosis in cancer cells induced by the Chinese traditional herbal medicine plant Lithospermum erythrorhizon (L. erythrorhizon, Zi Cao) and to investigate the potential mechanism. Methods: L. erythrorhizon was extracted by ultrasonication in 95% ethanol, and determined using high-performance liquid chromatography ...
Sanjiao Wang, Zhaoheng Liu, Jiajian Guo, Yunqian Li, Yue Zhang, Mingrui Yang, Guoqi Niu, Wenfu Ma   +7 more
openaire   +2 more sources

Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma [PDF]

Background: Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood ...
Chan, Stephen Lam, Chen, Shufen, Chen, Siyun, Cheng, Alfred Sze Lok, Feng, Yu, Kerr, David, Kwong, Tsz Tung, La Thangue, Nick, Leung, Howard, Liang, Jianxin, Liang, Liying, Liang, Zhixian, Lin, Yingnan, Liu, Yan, Lu, Jiahuan, Ma, Stephanie, Ren, Weida, Si-Tou, Willis Wai Yiu, Sun, Hanyong, Sung, Joseph J.Y., To, Ka Fai, Tong, Man, Tu, Yalin, Vong, Joaquim S.L., Wang, Jing, Wong, Patrick Pak Chun, Wu, Haoran, Xia, Qiang, Xiong, Zhewen, Yang, Weiqin, Yin, Baoyi, Zhang, Lingyun, Zhong, Chengpeng, Zhou, Jingying   +33 more
core   +4 more sources

NLRP3 Selectively Drives IL-1β Secretion by Pseudomonas aeruginosa Infected Neutrophils and Regulates Corneal Disease Severity [PDF]

, 2023
Macrophages infected with Gram-negative bacteria expressing Type III secretion system (T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent, but GSDME independent IL-1β secretion and pyroptosis.
Abbondante, Serena, Dubyak, George R, Liboro, Karl, Lima, Tatiane S, Marshall, Michaela E, Miller, Brandon A, Minns, Martin S, Pearlman, Eric, Rietsch, Arne, Roistacher, Alicia, Tran Chau, Jolynn   +10 more
core   +1 more source

BIX‐01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME‐mediated pyroptosis [PDF]

Cell Biology International, 2020
AbstractAdjuvant chemotherapy in combination with surgery is expected to be a curative strategy for gastric cancer. However, drug resistance remains an obstacle in effective chemotherapy. Therefore, understanding the potential mechanisms of chemotherapy induced gastric cancer cell death is of great importance.
Bei‐Bei Deng, Bao‐Ping Jiao, Yang‐Jun Liu, Yan‐Rong Li, Gui‐Jun Wang   +4 more
openaire   +2 more sources

Pyroptosis in Neutrophils: Multimodal Integration of Inflammasome and Regulated Cell Death Signaling Pathways [PDF]

, 2023
Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma membrane (PM) macropores composed of gasdermin-family (GSDM) proteins.
Dubyak, George R, Miller, Brandon A, Pearlman, Eric   +2 more
core   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Gasdermins in Apoptosis: New players in an Old Game. [PDF]

, 2019
Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism.
Alnemri, Emad S., Rogers, Corey
core   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source