Results 121 to 130 of about 1,125 (150)

Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma [PDF]

Journal of Allergy and Clinical Immunology, 2007
S-nitrosothiols are potent endogenous bronchodilators depleted in asthmatic airway lining fluid. S-nitrosoglutathione reductase (GSNOR; also known as alcohol dehydrogenase 5 or formaldehyde dehydrogenase) catalyzes the metabolism of S-nitrosoglutathione (GSNO) and controls intracellular levels of S-nitrosothiols. GSNOR knockout mice have increased lung
Stephanie London, Juan-Jose Sienra-Monge, Blanca Estela Del Rio-Navarro   +2 more
exaly   +3 more sources

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Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation

Circulation Research, 2023
BACKGROUND: The cardiac-protective role of GSNOR (S-nitrosoglutathione reductase) in the cytoplasm, as a denitrosylase enzyme of S-nitrosylation, has been reported in cardiac remodeling, but whether GSNOR is localized in other organelles and exerts novel effects remains unknown.
Xin Tang, Shuang Zhao, Jieqiong Liu, Xiameng Liu, Xinqi Sha, Changgao Huang, Lulu Hu, Shixiu Sun, Yuanqing Gao, Hongshan Chen, Zhiren Zhang, Dongjin Wang, Yuexi Gu, Shaoliang Chen, Liansheng Wang, Aihua Gu, Feng Chen, Jun Pu, Xin Chen, Bo Yu, Liping Xie, Zhengrong Huang, Yi Han, Yong Ji   +23 more
openaire   +2 more sources

Tumor Suppressor Roles of the Denitrosylase GSNOR

Critical Reviews™ in Oncogenesis, 2016
Nitric oxide (NO) is a gaseous pleiotropic molecule that can both induce irreversible oxidative damages and modulate physiological signal transductions by transient protein modifications, the most important of which is the S-nitrosylation of cysteine residues.
Rizza, Salvatore, Filomeni, Giuseppe
openaire   +4 more sources

GSNOR deficiency enhances betulin production in Betula platyphylla

Trees - Structure and Function, 2018
This paper showed that GSNOR mediated betulin production from genetic and pharmacological levels. The aim of this study was to investigate the relationship between S-nitrosoglutathione reductase (GSNOR) and betulin production. Treatment of birch suspension cells with 20 μmol/L GSNOR inhibitor 3-(5-(4-(1H-imidazol-1-yl) phenyl)-1-(4-carbamoyl-2 ...
Guizhi Fan, Guizhi Fan, Fan Guizhi
exaly   +2 more sources

GSNOR-mediated de-nitrosylation in the plant defence response

Plant Science, 2011
A key feature of the plant defence response is the transient engagement of a nitrosative burst, resulting in the synthesis of reactive nitrogen intermediates (RNIs). Specific, highly reactive cysteine (Cys) residues of low pK(a) are a major site of action for these intermediates.
Saad I, Malik, Adil, Hussain, Byung-Wook, Yun, Steven H, Spoel, Gary J, Loake   +4 more
openaire   +2 more sources

Denitrosylate and live longer: how ADH5/GSNOR links mitophagy to aging [PDF]

Autophagy, 2018
Mitochondrial dynamics is required to adapt the manifold functions of mitochondria to cell needs and regulate their turnover by mitophagy. Actually, only if fragmented, mitochondria are engulfed by phagophores, the precursors to autophagosomes, and subsequently degraded. This process is essential to maintain a correct and healthy number of mitochondria
Salvatore Rizza, Giuseppe Filomeni
exaly   +4 more sources

Chronicles of a reductase: Biochemistry, genetics and physio-pathological role of GSNOR

Free Radical Biology and Medicine, 2017
S-nitrosylation is a major redox posttranslational modification involved in cell signaling. The steady state concentration of S-nitrosylated proteins depends on the balance between the relative ability to generate nitric oxide (NO) via NO synthase and to reduce nitrosothiols by denitrosylases.
Salvatore Rizza, Giuseppe Filomeni
exaly   +4 more sources

Evidence for an Allosteric S-Nitrosoglutathione Binding Site in S-Nitrosoglutathione Reductase (GSNOR) [PDF]

Antioxidants, 2019
Current research has identified S-nitrosoglutathione reductase (GSNOR) as the central enzyme for regulating protein S-nitrosylation. In addition, the dysregulation of GSNOR expression is implicated in several organ system pathologies including respiratory, cardiovascular, hematologic, and neurologic, making GSNOR a primary target for pharmacological ...
Sahar Nikoo, James W Gauld, Cristina Lento   +2 more
exaly   +3 more sources

Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke

Brain Research, 2020
The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (GSNOR) provides protective effects ...
Mushfiquddin Khan, Pavan Kumar, Fei Qiao, S.M. Touhidul Islam, Avtar K. Singh, Je-Seong Won, Wayne Feng, Inderjit Singh   +7 more
openaire   +2 more sources

Regulation of NOS2-derived bioactivity through GSNOR inhibition

Nitric Oxide, 2012
The S-nitrosoglutathione (GSNO)-metabolizing enzyme, GSNO reductase (GSNOR), is a central regulator of protein S-nitrosylation. Accumulating data suggests that GSNOR inhibition might be a useful therapeutic strategy, but the in vitro and in vivo effects of GSNOR inhibitors have not been fully investigated.
Matthew Foster, Zhonghui Yang, Erin Potts-Kant, W. Michael Foster, Loretta Que   +4 more
openaire   +1 more source