Results 131 to 140 of about 1,125 (150)

Glycolysis Inhibition Restores Immune Sensitivity in GSNOR–Deficient Colorectal Cancer

Laboratory Investigation
S-nitrosoglutathione reductase (GSNOR) is increasingly recognized as a tumor suppressor, and we have recently reported that its deficiency drives an aggressive and immune-evasive phenotype in colorectal cancer (CRC). However, the mechanisms linking GSNOR loss to immune escape remain incompletely understood.
Antonio Rodriguez-Ariza, Maria Victoria García Ortiz, Silvia Guil Luna   +2 more
exaly   +3 more sources

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NEDD4–Mediated GSNOR Degradation Aggravates Cardiac Hypertrophy and Dysfunction

Circulation Research
BACKGROUND: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression of cardiomyopathy in response to hemodynamic stress. However, the mechanisms under GSNOR decrease remain unclear.
Xin Tang, Xiameng Liu, Xinqi Sha, Yan Zhang, Yan Zu, Qiyao Fan, Lulu Hu, Shixiu Sun, Zhiren Zhang, Feng Chen, ChengHui Yan, Xin Chen, Yueyue Xu, Wen Chen, Yongfeng Shao, Jiaxi Gu, Jun Pu, Bo Yu, Yaling Han, Liping Xie, Yi Han, Yong Ji   +21 more
openaire   +2 more sources

S-nitrosoglutathione reductase (GSNOR) downregulation in Breast Cancer: a possible involvement of miRNAs in controlling GSNOR expression

Free Radical Biology and Medicine, 2023
Gianmarco Matrullo, Valeria Fiorentini, Costanza Montagna, Giuseppe Filomeni, Salvatore Rizza   +4 more
openaire   +1 more source

GSNOR Impaired Cognitive Function in Aging Through De-Nitrosation of CamKIIalpha

Free Radical Biology and Medicine, 2016
As a result of the acceleration of population aging, an increasing number of people suffer from age related cognitive impairment. However, the mechanisms that underlie this process are unclear. Here we found that S-nitrosoglutathione reductase (GSNOR), the key enzyme metabolizing the intracellular nitric oxide (NO) and S-nitrosation, significantly ...
Zhang Yuying, Chen Chang
openaire   +1 more source

Activation of GSNOR transcription by NF-κB negatively regulates NGF-induced PC12 differentiation

Free Radical Research, 2014
S-nitrosoglutathione reductase (GSNOR) is the key enzyme controlling the intracellular levels of S-nitrosoglutathione and S-nitrosothiols. GSNOR has been implicated in many biological processes, such as the cardiovascular and respiratory systems. However, the role of GSNOR, the sole brain alcohol dehydrogenase, in the nervous systems is still largely a
K, Wu, Y, Zhang, P, Wang, L, Zhang, T, Wang, C, Chen   +5 more
openaire   +2 more sources

Design, Synthesis, and Anti-ischemic Stroke Activity Evaluation of Novel GSNOR Inhibitors

Journal of Medicinal Chemistry
S-nitrosoglutathione reductase (GSNOR), a key regulator of protein S-nitrosation, is a promising therapeutic target for cerebral ischemia. We report the design, synthesis, and evaluation of indole-based GSNOR inhibitors with potent anti-ischemic activity.
Zhuangzhuang Liang, Qing Zhao, Yuze Sun, Ganghai Li, Huiqin Chen, Chen Zhang, Jiayue Yu, Mengshuang Huang, Cunrui Li, Haoyang Tang, Tao Xiong, Yihua Zhang, Hui Ye, Zhangjian Huang, Jianbing Wu   +14 more
openaire   +2 more sources

Targeting GSNOR deficiency as a new therapeutic approach in rhabdomyosarcoma

Free Radical Biology and Medicine, 2023
Giovanni Larotondo, Paola Giglio, Gianmarco Matrullo, Emiliano Maiani, Giuseppe Filomeni, Costanza Montagna   +5 more
openaire   +1 more source

GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson's disease

Free Radical Biology and Medicine, 2022
Yong-Gang Yao, Rongcan Luo, Xinhua Qiao   +2 more
exaly  

Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress

EMBO Reports, 2021
Claudia Cirotti, Salvatore Rizza, Ji Hoon Lee   +2 more
exaly  

GSNOR Phenotyping/GSNO Challenge

Case Medical Research, 2019
openaire   +1 more source